Results 31 to 40 of about 4,480 (203)

A novel Penicillium sumatraense isolate reveals an arsenal of degrading enzymes exploitable in algal bio-refinery processes

Biotechnology for Biofuels, 2021
Background Microalgae are coming to the spotlight due to their potential applications in a wide number of fields ranging from the biofuel to the pharmaceutical sector. However, several factors such as low productivity, expensive harvesting procedures and
M. Giovannoni, I. Larini, V. Scafati, A. Scortica, M. Compri, D. Pontiggia, G. Zapparoli, N. Vitulo, M. Benedetti, B. Mattei   +9 more
doaj   +1 more source

A Non-redundant Function of MNS5: A Class I α-1, 2 Mannosidase, in the Regulation of Endoplasmic Reticulum-Associated Degradation of Misfolded Glycoproteins

Frontiers in Plant Science, 2022
Endoplasmic Reticulum-Associated Degradation (ERAD) is one of the major processes in maintaining protein homeostasis. Class I α-mannosidases MNS4 and MNS5 are involved in the degradation of misfolded variants of the heavily glycosylated proteins, playing
Xiaoxia Sun, Chenchen Guo, Khawar Ali, Qian Zheng, Qiang Wei, Yumeng Zhu, Li Wang, Guishuang Li, Wenjuan Li, Bowen Zheng, Qunwei Bai, Guang Wu   +11 more
doaj   +1 more source

Pyrrolidine Derivatives as New Inhibitors of ?-Mannosidases and Growth Inhibitors of Human Cancer Cells

CHIMIA, 2006
New pyrrolidine-3,4-diol derivatives were prepared from D-(?)- and L-(+)-phenylglycinol and tested for their ability to inhibit 25 commercial glycosidases.
Hélène Fiaux, Catherine Schütz, Pierre Vogel, Lucienne Juillerat-Jeanneret, Sandrine Gerber-Lemaire   +4 more
doaj   +1 more source

Structure and activity of the Streptococcus pyogenes family GH1 6-phospho β-glycosidase, Spy1599 [PDF]

, 2013
The group A streptococcus Streptococcus pyogenes is the causative agent of a wide spectrum of invasive infections, including necrotizing fasciitis, scarlet fever and toxic shock syndrome.
Aguilar-Moncayo, Ajdić, Cantarel, Collin, Conejo, Cowtan, Cowtan, Edward J. Taylor, Emsley, Evans, Fujita, Gideon J. Davies, Gregg, Harry Brumer, Henrissat, Henrissat, Hondorp, Jens M. Eklof, Jerome Dabin, Jin, Johan P. Turkenburg, Judith Stepper, Kabsch, Kietzman, Kori, Leslie, McNicholas, Murshudov, Padilla, Pancholi, Prachumporn Kongsaeree, Preeyanuch Thongpoo, Ryan, Ryan, Seshadri, Shelburne, Shelburne, Shelburne, Sheldon, Suck, Suits, Vagin, Wiesmann, Wiesmann, Winn, Winter, Wright, Zechel   +47 more
core   +1 more source

Bacteroides thetaiotaomicron generates diverse α-mannosidase activities through subtle evolution of a distal substrate-binding motif [PDF]

, 2018
A dominant human gut microbe, the well studied symbiont Bacteroides thetaiotaomicron (Bt), is a glyco-specialist that harbors a large repertoire of genes devoted to carbohydrate processing.
Ashkenazy, Cowtan, Cuskin, Davies, Emsley, Evans, Gorin, Granier, Holm, Imhof, Kabsch, Karaveg, Kau, Landau, Lombard, Marcobal, Martens, McCoy, McNicholas, Murshudov, Nielsen, Numao, Pei, Robb, Sonnenburg, Suits, Tailford, Tankrathok, Terinek, Thompson, Tiels, Vallée, Williams, Winn, Xu, Zhu   +35 more
core   +2 more sources

Hydrogen peroxide regulates endothelial surface N-glycoforms to control inflammatory monocyte rolling and adhesion

Redox Biology, 2020
Monocyte extravasation through the endothelial layer is a hallmark of atherosclerotic plaque development and is mediated by heavily N-glycosylated surface adhesion molecules, such as intercellular adhesion molecule-1 (ICAM-1). N-glycosylation is a key co-
Kellie R. McDonald, Alexandria L. Hernandez-Nichols, Jarrod W. Barnes, Rakesh P. Patel   +3 more
doaj   +1 more source

Enhanced SCAP glycosylation by inflammation induces macrophage foam cell formation. [PDF]

PLoS ONE, 2013
Inflammatory stress promotes foam cell formation by disrupting LDL receptor feedback regulation in macrophages. Sterol Regulatory Element Binding Proteins (SREBPs) Cleavage-Activating Protein (SCAP) glycosylation plays crucial roles in regulating LDL ...
Chao Zhou, Han Lei, Yaxi Chen, Qing Liu, Lung-Chih Li, John F Moorhead, Zac Varghese, Xiong Z Ruan   +7 more
doaj   +1 more source

Mannosidase Production by Viridans Group Streptococci [PDF]

Journal of Clinical Microbiology, 2001
ABSTRACT The production of mannosidase activity by all currently recognized species of human viridans group streptococci was determined using an assay in which bacterial growth was dependent on the degradation of the high-mannose-type glycans of RNase B and subsequent utilization of released mannose.
Homer, K A, Roberts, G, Byers, H L, Tarelli, E, Whiley, R A, Philpott-Howard, J, Beighton, D   +6 more
openaire   +3 more sources

Emerging Structural Insights into Glycoprotein Quality Control Coupled with N-Glycan Processing in the Endoplasmic Reticulum

Molecules, 2015
In the endoplasmic reticulum (ER), the sugar chain is initially introduced onto newly synthesized proteins as a triantennary tetradecasaccharide (Glc3Man9GlcNAc2).
Tadashi Satoh, Takumi Yamaguchi, Koichi Kato   +2 more
doaj   +1 more source

Deoxysugars as Antituberculars and Alpha-Mannosidase Inhibitors [PDF]

Antimicrobial Agents and Chemotherapy, 2014
ABSTRACT A promising modified sugar molecule was identified which was active against multidrug-resistant (MDR) strains of Mycobacterium tuberculosis , suggesting involvement of a new target. The compound was demonstrated to be bactericidal, inhibited the growth of M. tuberculosis in
Vivek, Kashyap, Smriti, Sharma, Vinayak, Singh, Sandeep K, Sharma, Mohammad, Saquib, Ranjana, Srivastava, Arun K, Shaw   +6 more
openaire   +2 more sources