The N-glycan glycoprotein deglycosylation complex (Gpd) from Capnocytophaga canimorsus deglycosylates human IgG. [PDF]
PLoS Pathogens, 2011 C. canimorsus 5 has the capacity to grow at the expenses of glycan moieties from host cells N-glycoproteins. Here, we show that C. canimorsus 5 also has the capacity to deglycosylate human IgG and we analyze the deglycosylation mechanism.
Francesco Renzi +5 more
doaj +1 more source
Studies toward New Anti-Cancer Strategies Based on ?-Mannosidase Inhibition
CHIMIA, 2010 Changes in the glycosylation pattern of cellular glycoproteins constitute a hallmark in human cancer and influence tumor progression, suggesting that inhibitors of selected glycosidases may control cancer progression.
Sandrine Gerber-Lemaire +1 more
doaj +1 more source
Structure- and context-based analysis of the GxGYxYP family reveals a new putative class of glycoside hydrolase. [PDF]
, 2014 BackgroundGut microbiome metagenomics has revealed many protein families and domains found largely or exclusively in that environment. Proteins containing the GxGYxYP domain are over-represented in the gut microbiota, and are found in Polysaccharide ...
Chang, Yuanyuan +5 more
core +2 more sources
Memorias do Instituto Oswaldo Cruz, 2008 Protein glycosylation pathways, commonly found in fungal pathogens, offer an attractive new area of study for the discovery of antifungal targets. In particular, these post-translational modifications are required for virulence and proper cell wall ...
Héctor M Mora-Montes +4 more
doaj +1 more source
Computational design-of-experiment unveils the conformational reaction coordinate of GH125 α-mannosidases [PDF]
, 2017 Conformational analysis of enzyme-catalyzed mannoside hydrolysis has revealed two predominant conformational itineraries through B 2,5 or 3H 4 transitionstate (TS) conformations.
Alonso-Gil, Santiago +5 more
core +1 more source
Combined inhibitor free-energy landscape and structural analysis reports on the mannosidase conformational coordinate [PDF]
, 2013 Mannosidases catalyze the hydrolysis of a diverse range of polysaccharides and glycoconjugates, and the various sequence-based mannosidase families have evolved ingenious strategies to overcome the stereoelectronic challenges of mannoside chemistry ...
Ardèvol +20 more
core +3 more sources
Beilstein Journal of Organic Chemistry, 2018 A synthetic approach to 1,4-imino-L-lyxitols with various modifications at the C-5 position is reported. These imino-L-lyxitol cores were used for the preparation of a series of N-(4-halobenzyl)polyhydroxypyrrolidines.
Maroš Bella +4 more
doaj +1 more source
Structure and kinetic investigation of Streptococcus pyogenes family GH38 alpha-mannosidase.
PLoS ONE, 2010 BackgroundThe enzymatic hydrolysis of alpha-mannosides is catalyzed by glycoside hydrolases (GH), termed alpha-mannosidases. These enzymes are found in different GH sequence-based families.
Michael D L Suits +6 more
doaj +1 more source
Fungal ecological strategies reflected in gene transcription - a case study of two litter decomposers. [PDF]
, 2019 Microbial communities interplay with their environment through their functional traits that can be a response or an effect on the environment. Here, we explore how a functional trait-the decomposition of organic matter, can be addressed based on genetic ...
Barbi, Florian +14 more
core +3 more sources
Bioinformatic characterisation of genes encoding cell wall degrading enzymes in the Phytophthora parasitica genome [PDF]
, 2016 BACKGROUND A critical aspect of plant infection by the majority of pathogens is penetration of the plant cell wall. This process requires the production and secretion of a broad spectrum of pathogen enzymes that target and degrade the many complex ...
Blackman, Leila M. +2 more
core +2 more sources