Results 131 to 140 of about 288,019 (165)

The Primary Structure of a Human Map Kinase Activated Protein Kinase 2

Biochemical and Biophysical Research Communications, 1994
Mitogen-activated protein (MAP) kinase is of central importance in mediating intracellular actions in response to a variety of extracellular stimuli. MAP kinase activated protein (MAPKAP) kinase 2 is one of the two known protein kinases that can be phosphorylated and activated by MAP kinase.
Y L, Zu, F, Wu, A, Gilchrist, Y, Ai, M E, Labadia, C K, Huang   +5 more
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Cellular expression of map 2 kinase in rat brain

Histochemistry and Cell Biology, 1996
The cellular localization of microtubule-associated protein (MAP) 2 kinase mRNA in rat brain was examined by in situ hybridization histochemistry using a synthetic oligonucleotide probe. MAP 2 kinase was expressed in both neuronal and non-neuronal cells.
D M, Jacobowitz, L, Winsky, S D, Detera-Wadleigh   +2 more
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Differential regulation of MAP kinase activation by a novel splice variant of human MAP kinase phosphatase-2

Cellular Signalling, 2010
MAP kinase phosphatase-2 (MKP-2) is a member of the family of dual specificity phosphatases that functions to inactivate the ERK and JNK MAP kinase signalling pathways. Here, we identify a novel human MKP-2 variant (MKP-2-S) lacking the MAP kinase binding site but retaining the phosphatase catalytic domain.
Cadalbert, C., Sloss, C.M., Cunningham, M.M., Al-Muteiri, M., McIntire, A., Shipley, J., Plevin, R.   +6 more
openaire   +4 more sources

Mapping the Functional Domains of Elongation Factor-2 Kinase

Biochemistry, 2000
A new class of eukaryotic protein kinases that are not homologous to members of the serine/threonine/tyrosine protein kinase superfamily was recently identified [Futey, L. M., et al. (1995) J. Biol. Chem. 270, 523-529; Ryazanov, A. G., et al. (1997) Proc. Natl. Acad. Sci. U.S.A. 94, 4884-4889]. This class includes eukaryotic elongation factor-2 kinase,
K S, Pavur, A N, Petrov, A G, Ryazanov
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ERKs, extracellular signal-regulated MAP-2 kinases

Current Opinion in Cell Biology, 1991
A family of protein kinases, known alternatively as microtubule-associated protein-2/myelin basic protein kinases or extracellular signal-regulated kinases, is activated by numerous hormones, growth factors and other extracellular stimuli. At least two members of this family function as intermediate kinases in protein phosphorylation cascades.
M H, Cobb, D J, Robbins, T G, Boulton
openaire   +2 more sources

Constitutive Activation of MAP Kinase Kinase (MEK1) Is Critical and Sufficient for the Activation of MMP-2

Experimental Cell Research, 2000
We investigated the role of MEK1 signaling in MMP-2 activation by use of constitutive active/dominant negative forms of MEK1 and MEK1-specific inhibitor. We found that cell transformation with active forms of MEK1 dramatically increased secretion and proteolytic activation of MMP-2 and subsequently stimulated invasiveness of cells. Contrary, expression
H, Kurata, A A, Thant, S, Matsuo, T, Senga, K, Okazaki, N, Hotta, M, Hamaguchi   +6 more
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Acute Lymphoid and Gastrointestinal Toxicity Induced by Selective p38α Map Kinase and Map Kinase–Activated Protein Kinase-2 (MK2) Inhibitors in the Dog

Toxicologic Pathology, 2010
Exposure to moderately selective p38α mitogen-activated protein kinase (MAPK) inhibitors in the Beagle dog results in an acute toxicity consisting of mild clinical signs (decreased activity, diarrhea, and fever), lymphoid necrosis and depletion in the gut-associated lymphoid tissue (GALT), mesenteric lymph nodes and spleen, and linear colonic and cecal
Dale L, Morris, Shawn P, O'Neil, Rajesh V, Devraj, Joseph P, Portanova, Richard W, Gilles, Cindy J, Gross, Sandra W, Curtiss, Wendy J, Komocsar, Debra S, Garner, Fernando A, Happa, Lori J, Kraus, Kristen J, Nikula, Joseph B, Monahan, Shaun R, Selness, Gerald R, Galluppi, Kimberly M, Shevlin, Jeffrey A, Kramer, John K, Walker, Dean M, Messing, David R, Anderson, Robert J, Mourey, Laurence O, Whiteley, John S, Daniels, Jerry Z, Yang, Philip C, Rowlands, Carl L, Alden, John W, Davis, John E, Sagartz   +27 more
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E-2. Inhibitors of MAP kinases

Lung Cancer, 2003
Mitogen activated protein (MAP) kinase cascades form a threekinase signaling module involved in transmitting membrane signals to the cell nucleus (Fig 1). In mammals, three major groups of MAPK have been identified the ERK, ~38 and JNK groups. A MAPK module consists of MAP kinase or extracellular signalgegulated &nase (ERK) activated by a MAP/ERK ...
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High Expression and Activation of MAP Kinase-activated Protein Kinase 2 in Cardiac Muscle Cells

Journal of Molecular and Cellular Cardiology, 1997
Recently, three mammalian mitogen-activated protein (MAP) kinases, ERK, SAPK/JNK, and p38/HOG-1 have been identified, each with apparently unique signal transduction pathways. The p38 MAP kinase mediates an intracellular stress-activated signaling pathway by regulating down-stream molecules, such as MAP kinase-activated protein (MAPKAP) kinase 2.
Y L, Zu, Y, Ai, A, Gilchrist, N, Maulik, J, Watras, R I, Sha'afi, D K, Das, C K, Huang   +7 more
openaire   +2 more sources