Results 141 to 150 of about 288,019 (165)

MAP kinase protects G protein-coupled receptor kinase 2 from proteasomal degradation

Biochemical and Biophysical Research Communications, 2005
The G protein-coupled receptor kinase 2 (GRK2) phosphorylates and shuts down signaling from 7-transmembrane receptors (7TMs). Although, receptor activity controls GRK2 expression levels, the underlying molecular mechanisms are poorly understood. We have previously shown that extracellular signal-regulated kinase (ERK1/2) activation increases GRK2 ...
Juliane, Theilade, Jakob L, Hansen, Stig, Haunsø, Søren P, Sheikh   +3 more
openaire   +2 more sources

Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II

Nature, 1988
Ribosomal protein S6 is a component of the eukaryotic 40S ribosomal subunit that becomes phosphorylated on multiple serine residues in response to a variety of mitogens, including insulin, growth factors, and transforming proteins of many oncogenic viruses.
T W, Sturgill, L B, Ray, E, Erikson, J L, Maller   +3 more
openaire   +2 more sources

MAP‐kinase‐activated protein kinase 2 expression and activity is induced after neuronal depolarization

European Journal of Neuroscience, 2008
AbstractMitogen‐activated protein kinase‐activated protein kinase (MK)2 is one of several downstream targets of p38 mitogen‐activated protein kinase and has a well documented role in inflammation. Here, we describe a possible new function of MK2. We show that triggering depolarization by potassium chloride or increasing the cellular cAMP by forskolin ...
Tobias, Thomas, Edward, Hitti, Alexey, Kotlyarov, Heidrun, Potschka, Matthias, Gaestel   +4 more
openaire   +2 more sources

Interaction of MAP kinase with MAP kinase kinase: its possible role in the control of nucleocytoplasmic transport of MAP kinase

EMBO Journal, 1997
Yukiko Gotoh, Eisuke Nishida, Makoto Fukuda   +2 more
exaly  

Inhibition of p38 MAP kinase as a therapeutic strategy

Immunopharmacology, 2000
Saran Kumar, Jerry L Adams, D E Griswold   +2 more
exaly  

PRAK, a novel protein kinase regulated by the p38 MAP kinase

EMBO Journal, 1998
Jiahuai Han, Yutaka Kato, Liguo New
exaly  

TNF and MAP kinase signalling pathways

Seminars in Immunology, 2014
Roger Davis, Guadalupe Sabio
exaly  

MAP kinase and the activation of quiescent cells

Current Opinion in Cell Biology, 1993
Joan V Ruderman, J V Ruderman
exaly  

MAP kinase kinase kinase, MAP kinase kinase and MAP kinase

Current Opinion in Genetics and Development, 1994
Christopher J Marshall, C J Marshall
exaly  

Distinct regulation of salinity and genotoxic stress responses by Arabidopsis MAP kinase phosphatase 1

EMBO Journal, 2002
Kazuya Ichimura, Roman Ulm, Jerzy Paszkowski   +2 more
exaly