Results 91 to 100 of about 1,043,830 (367)

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

The Development Of Chemical Methods To Discover Kinase Substrates And Map Cell Signaling With Gamma-Modified Atp Analog-Dependent Kinase-Catalyzed Phosphorylation [PDF]

, 2017
Kinase-catalyzed phosphorylation plays an important role in cell physiology by regulating a myriad of cellular functions. Thus aberrant kinase activity is implicated in various diseases.
Embogama, Dissanayaka Mudiyanselage Maheeka Madhubashini
core   +1 more source

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source

Pramanicin induces apoptosis in Jurkat leukemia cells; a role for JNK, p38 and caspase activation [PDF]

, 2005
Pramanicin is a novel anti-fungal drug with a wide range of potential application against human diseases. It has been previously shown that pramanicin induces cell death and increases calcium levels in vascular endothelial cells. In the present study, we
Başağa, Hüveyda, Harris, P., Kütük, Özgür, Pedrech, A.   +3 more
core   +1 more source

Dominant Mutations of Drosophila MAP Kinase Kinase and Their Activities in Drosophila and Yeast MAP Kinase Cascades [PDF]

Genetics, 1997
Eight alleles of Dsor1 encoding a Drosophila homologue of mitogen-activated protein (MAP) kinase kinase were obtained as dominant suppressors of the MAP kinase kinase kinase D-raf. These Dsor1 alleles themselves showed no obvious phenotypic consequences nor any effect on the viability of the flies, although they were highly sensitive to upstream ...
Yasuyoshi Nishida, Young-Mi Lim, Takashi Adachi-Yamada, Kenji Irie, Mami Hata, Yoshimi Nishi, Yoshihiro H. Inoue, Leo Tsuda, Kunihiro Matsumoto   +8 more
openaire   +3 more sources

Protein kinases as potential anticandidal drug targets

Frontiers in Bioscience-Landmark, 2020
Candidal infections are increasing at an alarming rate due to hospital acquired infections causing high mortality rates worldwide. Moreover, the emergence of drug resistant Candida strains is the major impediment against effective therapeutics.
Shweta Singh, Suriya Rehman, Zeeshan Fatima, Saif Hameed   +3 more
doaj   +1 more source

The chemotactic factor N-formylmethionyl-leucyl-phenylalanine activates microtubule-associated protein 2 (MAP) kinase and a MAP kinase kinase in polymorphonuclear leucocytes.

Biochemical Journal, 1993
Incubation of human polymorphonuclear leucocytes (PMN) with either the chemotactic factor N-formylmethionyl-leucylphenylalanine (FMLP) or phorbol 12-myristate 13-acetate (PMA) activates a kinase with phosphorylating activity towards a known microtubule ...
H. Thompson, Masahiro SHIROOt, Jeremy Saklatvala   +2 more
semanticscholar   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Immunolocalization of dually phosphorylated MAPKs in dividing root meristem cells of Vicia faba, Pisum sativum, Lupinus luteus and Lycopersicon esculentum [PDF]

, 2015
Key message In plants, phosphorylated MAPKs display constitutive nuclear localization; however, not all studied plant species show co-localization of activated MAPKs to mitotic microtubules.
A Bessard, A Neupane, A Neupane, A Pitzschke, AK Sinha, Aneta Żabka, AP Smertenko, D Ortiz-Masia, F Kong, G Komis, G Taj, G Tena, H Nakagami, J Müller, J Schindelin, Janusz Maszewski, Joanna Bernasińska, K Kosetsu, Karolina Matczak, Konrad Winnicki, L Bögre, M Beck, M Beck, M Cargnello, M Fernandez-Pascual, M Ohori, M Ovečka, M Sasabe, M Wrzaczek, MA González Besteiro, MAPK Group, MM Horne, NS Mishra, O Šamajová, PJ Krysan, R Ulm, R Ulm, RM Perrett, T Hayashi, V Smékalová, W Ligterink, X Liu, X Qian   +42 more
core   +2 more sources

Growth factor‐stimulated MAP kinase induces rapid retrophosphorylation and inhibition of MAP kinase kinase (MEK1) [PDF]

FEBS Letters, 1994
The MAP kinase module (Raf/MAPKKK‐MAPKK‐MAPK) has been shown to be sequentially activated after mitogenic stimulation. Here we demonstrate, by site directed mutagenesis, that MAPK is able to retrophosphorylate its own activator, MAPKK, on two threonine residues Thr‐292 and Thr‐386 in vitro, and that these sites are also phosphorylated in vivo.
Gilles Pagès, Jacques Pouysségur, Anne Brunet   +2 more
openaire   +3 more sources