Results 101 to 110 of about 1,043,830 (367)

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

FEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt, Manuela Gellert, Finja Zelms, Sander Bekeschus, Christopher Horst Lillig   +4 more
wiley   +1 more source

Targeting RTK signaling pathways in cancer [PDF]

, 2015
The RAS/MAP kinase and the RAS/PI3K/AKT pathways play a key role in the regulation of proliferation, differentiation and survival. The induction of these pathways depends on Receptor Tyrosine Kinases (RTKs) that are activated upon ligand binding.
Regad, T
core   +1 more source

Identification of a latent MAP kinase kinase kinase in PC12 cells as B‐raf [PDF]

FEBS Letters, 1994
A latent MAP kinase kinase kinase activity previously detected after chromatography of PC12 cell extracts on Mono Q [(1992) FEBS Lett. 314, 461–465] has been identified as B‐Raf by immunoblotting and immunoprecipitation experiments and by its specific activation with B‐Raf antibodies.
Traverse, Sarah, Cohen, Philip
openaire   +3 more sources

Stress and Vascular Responses: Mitogen-Activated Protein Kinases and Activator Protein-1 as Promising Therapeutic Targets of Vascular Remodeling

Journal of Pharmacological Sciences, 2003
Mitogen-activated protein kinases (MAP kinases), including extracellular signal-regulated kinase (ERK), c-Jun NH2-terminal kinase (JNK), and p38, play a central role in cellular responses by various stress stimuli such as cell proliferation, apoptosis ...
Shokei Kim, Hiroshi Iwao
doaj  

Construction of human activity‐based phosphorylation networks

Molecular Systems Biology, 2013
The landscape of human phosphorylation networks has not been systematically explored, representing vast, unchartered territories within cellular signaling networks.
Robert H Newman, Jianfei Hu, Hee‐Sool Rho, Zhi Xie, Crystal Woodard, John Neiswinger, Christopher Cooper, Matthew Shirley, Hillary M Clark, Shaohui Hu, Woochang Hwang, Jun Seop Jeong, George Wu, Jimmy Lin, Xinxin Gao, Qiang Ni, Renu Goel, Shuli Xia, Hongkai Ji, Kevin N Dalby, Morris J Birnbaum, Philip A Cole, Stefan Knapp, Alexey G Ryazanov, Donald J Zack, Seth Blackshaw, Tony Pawson, Anne‐Claude Gingras, Stephen Desiderio, Akhilesh Pandey, Benjamin E Turk, Jin Zhang, Heng Zhu, Jiang Qian   +33 more
doaj   +1 more source

The Cryptosporidium parvum Kinome

BMC Genomics, 2011
Background Hundreds of millions of people are infected with cryptosporidiosis annually, with immunocompromised individuals suffering debilitating symptoms and children in socioeconomically challenged regions at risk of repeated infections.
Artz Jennifer D, Wernimont Amy K, Allali-Hassani Abdellah, Zhao Yong, Amani Mehrnaz, Lin Yu-Hui, Senisterra Guillermo, Wasney Gregory A, Fedorov Oleg, King Oliver, Roos Annette, Lunin Vlad V, Qiu Wei, Finerty Patrick, Hutchinson Ashley, Chau Irene, von Delft Frank, MacKenzie Farrell, Lew Jocelyne, Kozieradzki Ivona, Vedadi Masoud, Schapira Matthieu, Zhang Chao, Shokat Kevan, Heightman Tom, Hui Raymond   +25 more
doaj   +1 more source

TOR Complex 2- independent mutations in the regulatory PIF pocket of Gad8AKT1/SGK1 define separate branches of the stress response mechanisms in fission yeast.

PLoS Genetics, 2020
The Target of rapamycin (TOR) protein kinase forms part of TOR complex 1 (TORC1) and TOR complex 2 (TORC2), two multi-subunit protein complexes that regulate growth, proliferation, survival and developmental processes by phosphorylation and activation of
Emese Pataki, Luba Simhaev, Hamutal Engel, Adiel Cohen, Martin Kupiec, Ronit Weisman   +5 more
doaj   +1 more source

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

MAP3K kinases and kidney injury

Nefrología, 2019
Mitogen-activated protein kinases (MAP kinases) are functionally connected kinases that regulate key cellular process involved in kidney disease such as all survival, death, differentiation and proliferation.
Leticia Cuarental, David Sucunza-Sáenz, Lara Valiño-Rivas, Beatriz Fernandez-Fernandez, Ana Belen Sanz, Alberto Ortiz, Juan José Vaquero, Maria Dolores Sanchez-Niño   +7 more
doaj   +2 more sources

Pseudomonas aeruginosa induces p38MAP kinase-dependent IL-6 and CXCL8 release from bronchial epithelial cells via a Syk kinase pathway.

PLoS ONE, 2021
Pseudomonas aeruginosa (Pa) infection is a major cause of airway inflammation in immunocompromised and cystic fibrosis (CF) patients. Mitogen-activated protein (MAP) and tyrosine kinases are integral to inflammatory responses and are therefore potential ...
Matthew S Coates, Eric W F W Alton, Garth W Rapeport, Jane C Davies, Kazuhiro Ito   +4 more
doaj   +1 more source