Results 261 to 270 of about 117,345 (315)

Towards the targeted protein degradation of CK2: design and synthesis of CAM4066-based PROTACs. [PDF]

Beilstein J Org Chem
Day-Riley S, Krajcovicova S, Sokhal AR, Venne JL, Brear P, Hyvönen M, Whitehurst BC, Carroll JS, Spring DR.   +8 more
europepmc   +1 more source

Targeting UXS1‐Dependent Glucuronate Detoxification Potentiates Metformin's Anti‐Tumor Efficacy in Lung Adenocarcinoma

Advanced Science, EarlyView.
This study reveals that metformin promotes glucuronic acid metabolism in lung adenocarcinoma by activating UGDH S476 phosphorylation and enhancing the conversion of UDPG to UDPGA based on metabolomics analysis. Through compound virtual screening, it is found that plantainoside targeting UGDH downstream UXS1 leads to UDPGA toxicity accumulation ...
Qihai Sui, Zhencong Chen, Guangyao Shan, Zhengyang Hu, Xing Jin, Jiaqi Liang, Yanjun Yi, Jiacheng Yin, Haochun Shi, Xifei Jiang, Junjie Xi, Zongwu Lin, Cheng Zhan, Fenghao Sun, Wei Jiang   +14 more
wiley   +1 more source

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

Arbuscules up close: spatiotemporal and single cell translatomics in rice and arbuscular mycorrhizal symbiosis. [PDF]

Plant Cell
Mbaluto CM.
europepmc   +1 more source

Targeted degradation of MK2 is insufficient to block inflammatory cytokine production in human cells due to cooperativity with MK3 and MK5. [PDF]

Front Immunol
Yang B, Fang G, Marx I, Liu G, Skouras S, Sharma K, Walther DM, Bollinger Martinez S, Hubeau C, Shi Y, De Savi C, Huang X, Huhn A, Sawant R, Proctor WR, Dixit VS, Dong H, Weiss MM, Mainolfi N, Slavin A, Long AJ, Williams JA, Byrne FR.   +22 more
europepmc   +1 more source

Targeting of kinases to treat neurodegenerative diseases. [PDF]

Pharmacol Rev
Shomali T, Trempe JF.
europepmc   +1 more source

Molecular identifiers of the evolutionarily conserved titin pseudokinase. [PDF]

Biochem J
Dorendorf T, Gravenhorst P, Mayans O.
europepmc   +1 more source

Ole-4, a novel synthetic derivative of Oleuropein, enhances antitumor immunity and modulates kinase activity-dependent signaling. [PDF]

J Transl Med
Angelis NV, Paronis E, Sarikaki G, Nikolakopoulos KS, Velentzas AD, Mikropoulou EV, Stathopoulos P, Katsimpoulas M, Kostomitsopoulos NG, Aggeli IK, Papageorgis P, Kostopoulos IV, Efthimiopoulos S, Iliopoulos D, Baxevanis CN, Kostakis IK, Skaltsounis AL, Stravopodis DJ, Tsitsilonis OE.   +18 more
europepmc   +1 more source

Gene Expression Profiling of EGFR, FGFR2, PIK3CA, PTEN, SMAD4, STK11, and TP53 in Cell-Free RNA From Exhaled Breath Condensate: Diagnostic, Prognostic, and Therapeutic Implications in Advanced Lung Adenocarcinoma. [PDF]

Cancer Rep (Hoboken)
Latifova S, Genis U, Karakus HS, Korba K, Ozgur S, Aldag C, Goksel T, Pelit L, Gunduz C, Vardarli AT.   +9 more
europepmc   +1 more source