Results 271 to 280 of about 117,345 (315)

MAP kinase kinase kinases and innate immunity

Trends in Immunology, 2006
Toll-like receptors, which respond to invariant microbial molecules, and receptors for the proinflammatory cytokines tumour necrosis factor and interleukin-1 are crucial for initiation and regulation of innate immune responses. These receptors activate each of the major mitogen-activated protein (MAP) kinase subtypes, extracellular signal-regulated ...
Steven C Ley
exaly   +3 more sources

The Mnks: MAP kinase-interacting kinases (MAP kinase signal-integrating kinases)

Frontiers in Bioscience, 2008
The human MAP kinase-interacting kinases (or MAP kinase signal-integrating kinases), Mnks, comprise a group of four proteins derived from two genes (Gene symbols: MKNK1 and MKNK2) by alternative splicing. Mnk1a/b differ at their C-termini, as do Mnk2a/2b: in each case, the a-form possesses a longer C-terminal region than the b-form, which lacks the MAP
Buxade, Maria, Parra-Palau, Josep L., Proud, Christopher G.   +2 more
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MAP kinase kinase kinase, MAP kinase kinase and MAP kinase

Current Opinion in Genetics & Development, 1994
Signal transduction pathways that respond to external signals through the MAP kinase family of protein kinases are involved in diverse responses in eukaryotic cells. MAP kinases are one element in a series of kinases that serve to connect the plasma membrane with cytoplasmic and nuclear events. MAP kinases have the unusual feature that their activation
openaire   +2 more sources

Plant MAP kinase kinase kinases structure, classification and evolution

Gene, 1999
The increasing number of reports describing plant MAP kinase signalling components reflects the cardinal role that MAP kinase pathways are likely to play during plant growth and development. Relationship and structural analyses of plant MAP kinase kinase kinase related cDNAs and genes established, on one hand, the PMEKKs, which may be distinguished ...
S, Jouannic, A, Hamal, A S, Leprince, J W, Tregear, M, Kreis, Y, Henry   +5 more
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Isolation of ATMEKK1 (a MAP Kinase Kinase Kinase)-Interacting Proteins and Analysis of a MAP Kinase Cascade inArabidopsis

Biochemical and Biophysical Research Communications, 1998
In plants, a number of MAP kinase (MAPK), MAPK kinase (MAPKK), and MAPKK kinase (MAPKKK) homologues have been reported. However, there have been no reports of protein-protein interactions between these kinases or molecular analysis of MAPK cascades in higher plants.
K, Ichimura, T, Mizoguchi, K, Irie, P, Morris, J, Giraudat, K, Matsumoto, K, Shinozaki   +6 more
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Crystallization of MAP kinases

Methods, 2006
X-ray structural studies of MAP kinases and MAP kinase module components are elucidating how kinase activity is regulated and how specificity of signaling is conferred. In the past decade, MAP kinases have been crystallized in their active, phosphorylated forms or low-activity, unphosphorylated forms, as well as in the presence of binding partners such
Seung-Jae, Lee, Tianjun, Zhou, Elizabeth J, Goldsmith   +2 more
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Raf-1 activates MAP kinase-kinase

Nature, 1992
The normal cellular homologue of the acutely transforming oncogene v-raf is c-raf-1, which encodes a serine/threonine protein kinase that is activated by many extracellular stimuli. The physiological substrates of the protein c-Raf-1 are unknown.
J M, Kyriakis, H, App, X F, Zhang, P, Banerjee, D L, Brautigan, U R, Rapp, J, Avruch   +6 more
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Mapping the kinase domain of janus kinase 3

Bioorganic & Medicinal Chemistry Letters, 2003
The utilization and impact of parallel synthesis on lead exploration around initial hit oxindole (1) are described. The emergent SAR, analogue design and functional impact will also be detailed.
Christopher, Adams, David J, Aldous, Shelley, Amendola, Paul, Bamborough, Colin, Bright, Sarah, Crowe, Paul, Eastwood, Garry, Fenton, Martyn, Foster, Trevor K P, Harrison, Sue, King, Justine, Lai, Christopher, Lawrence, Jean-Philippe, Letallec, Clive, McCarthy, Neil, Moorcroft, Kenneth, Page, Sudha, Rao, Jane, Redford, Shazia, Sadiq, Keith, Smith, John E, Souness, Sukanthini, Thurairatnam, Mark, Vine, Barry, Wyman   +24 more
openaire   +2 more sources