Auditory Fear Conditioning and Long-Term Potentiation in the Lateral Amygdala Require ERK/MAP Kinase Signaling in the Auditory Thalamus: A Role for Presynaptic Plasticity in the Fear System [PDF]
Journal of Neuroscience, 2005 In the present study, we examined the role of the auditory thalamus [medial division of the medial geniculate nucleus and the adjacent posterior intralaminar nucleus (MGm/PIN)] in auditory pavlovian fear conditioning using pharmacological manipulation of intracellular signaling pathways.
Apergis-Schoute, Annemieke M +4 more
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Regulation of peripheral inflammation by spinal p38 MAP kinase in rats. [PDF]
PLoS Medicine, 2006 Somatic afferent input to the spinal cord from a peripheral inflammatory site can modulate the peripheral response. However, the intracellular signaling mechanisms in the spinal cord that regulate this linkage have not been defined.
David L Boyle +7 more
doaj +1 more source
c-Jun N-Terminal Kinase in Inflammation and Rheumatic Diseases. [PDF]
, 2012 The c-Jun N-terminal kinases (JNKs) are members of the mitogen-activated protein kinase (MAPK) family and are activated by environmental stress. JNK is also activated by proinflammatory cytokines, such as TNF and IL-1, and Toll-like receptor ligands ...
Firestein, Gary S, Guma, Monica
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Structure and dynamics of the E. coli chemotaxis core signaling complex by cryo-electron tomography and molecular simulations [PDF]
, 2020 To enable the processing of chemical gradients, chemotactic bacteria possess large arrays of transmembrane chemoreceptors, the histidine kinase CheA, and the adaptor protein CheW, organized as coupled core-signaling units (CSU). Despite decades of study,
Cassidy, Keith +8 more
core +1 more source
Integration of a Phosphatase Cascade with the MAP Kinase Pathway provides for a Novel Signal Processing Function [PDF]
, 2009 We mathematically modeled the receptor-activated MAP kinase signaling by incorporating the regulation through cellular phosphatases. Activation induced the alignment of a phosphatase cascade in parallel with the MAP kinase pathway.
Alon +54 more
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Parallel implementation of stochastic simulation for large-scale cellular processes [PDF]
, 2005 Experimental and theoretical studies have shown the importance of stochastic processes in genetic regulatory networks and cellular processes. Cellular networks and genetic circuits often involve small numbers of key proteins such as transcriptional ...
Burrage, K., Tian, T.
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Postsynaptic localization of PSD-95 is regulated by all three pathways downstream of TrkB signaling
Frontiers in Synaptic Neuroscience, 2014 BDNF and its receptor TrkB regulate synaptic plasticity. TrkB triggers three downstream signaling pathways; Phosphatidylinositol 3-kinase (PI3K), Phospholipase Cγ (PLC γ) and Mitogen activated protein kinases/ Extracellular signal-regulated kinases (MAPK/
Akira eYoshii, Martha eConstantine-Paton
doaj +1 more source
Interactions between Type III receptor tyrosine phosphatases and growth factor receptor tyrosine kinases regulate tracheal tube formation in Drosophila [PDF]
, 2012 The respiratory (tracheal) system of the Drosophila melanogaster larva is an intricate branched network of air-filled tubes. Its developmental logic is similar in some ways to that of the vertebrate vascular system.
Jeon, Mili, Scott, Matthew P., Zinn, Kai
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The Xanthomonas euvesicatoria type III effector XopAU is an active protein kinase that manipulates plant MAP kinase signaling. [PDF]
PLoS Pathogens, 2018 The Gram-negative bacterium Xanthomonas euvesicatoria (Xe) is the causal agent of bacterial spot disease of pepper and tomato. Xe delivers effector proteins into host cells through the type III secretion system to promote disease.
Doron Teper +5 more
doaj +1 more source
The neuronal MAP kinase cascade: a biochemical signal integration system subserving synaptic plasticity and memory [PDF]
Journal of Neurochemistry, 2001 The mitogen‐activated protein kinase (MAP kinase, MAPK) cascade, as the name implies, was originally discovered as a critical regulator of cell division and differentiation. As further details of this signaling cascade were worked out, it became clear that the MAPK cascade is in fact a prototype for a family of signaling cascades that share the motif ...
openaire +2 more sources