Results 41 to 50 of about 322,191 (274)

The zinc finger protein A20 inhibits TNF-induced NF-kappa B-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappa B-inhibiting protein ABIN. [PDF]

, 1999
A
Ballard, Bandres, Barnes, Bergmann, Beyaert, Boldin, Cao, Carpentier, Chen, Chu, Cooper, Darnay, DeLamarter, De Valck, De Valck, Dignam, Dixit, Eckner, Ferran, Fukushi, Geleziunas, Gerritsen, Harris, Henkel, Heyninck, Hsu, Hsu, Hsu, Hu, Ishida, Ishida, Jäättelä, Kelliher, Krikos, Laherty, Laherty, LeBail, Lee, Malinin, Mercurio, Min, Muzio, Natoli, Naumann, Ng, Niederman, Niwa, Opipari, Perkins, Plaisance, Reinhard, Sarma, Schreck, Semmes, Song, Southern, Uhlik, Van Antwerp, Vandenabeele, Vanden Berghe, W., S. Plaisance, E. Boone, K. De Bosscher, M.L. Schmitz, W. Fiers, and G. Haegeman, Vanhaesebroeck, Van Snick, Vincenz, Yeh, Yin, Yurochko, Zandi, Zhang, Zhong, Zhong   +69 more
core   +2 more sources

N-Methyl-D-Aspartate Receptor Link to the MAP Kinase Pathway in Cortical and Hippocampal Neurons and Microglia Is Dependent on Calcium Sensors and Is Blocked by α-Synuclein, Tau, and Phospho-Tau in Non-transgenic and Transgenic APPSw,Ind Mice

Frontiers in Molecular Neuroscience, 2018
N-methyl-D-aspartate receptors (NMDARs) respond to glutamate to allow the influx of calcium ions and the signaling to the mitogen-activated protein kinase (MAPK) cascade.
Rafael Franco, Rafael Franco, David Aguinaga, David Aguinaga, Irene Reyes, Irene Reyes, Enric I. Canela, Enric I. Canela, Jaume Lillo, Airi Tarutani, Masato Hasegawa, Anna del Ser-Badia, Anna del Ser-Badia, José A. del Rio, José A. del Rio, José A. del Rio, Michael R. Kreutz, Michael R. Kreutz, Carlos A. Saura, Carlos A. Saura, Gemma Navarro, Gemma Navarro   +21 more
doaj   +1 more source

The addition of PD-1/PD-L1 axis blockade to BRAF and MEK inhibition for advanced melanoma patients harboring BRAF mutations: a systematic review and meta-analysis

Brazilian Journal of Oncology, 2022
Objectives: Immune-checkpoint inhibitors (ICI) and targeted-therapies (TT) have become standard options for BRAF-V600 metastatic melanomas (MM). Recently, randomized trials (RCT) addressed the efficacy of combined approaches, with conflicting results. We
Mauricio Fernando Silva Almeida Ribeiro, Camila Bragança Xavier, Allan Andresson Lima Pereira, Mariana Scaranti, Luiza Dib Batista Bugiato Faria, Tatiana Strava Correa, Marina Sahade, David Queiroz Borges Muniz, Olavo Feher, Gustavo dos Santos Fernandes, Artur Katz, Rodrigo Ramella Munhoz   +11 more
doaj   +1 more source

CXCL12-induced neurotoxicity critically depends on NMDA receptor-gated and L-type Ca2+ channels upstream of p38 MAPK. [PDF]

, 2016
BackgroundThe chemokine receptor CXCR4 (CD184) and its natural ligand CXCL12 contribute to many physiological processes, including decisions about cell death and survival in the central nervous system.
Kaul, Marcus, Maung, Ricky, Medders, Kathryn E, Ojeda-Juárez, Daniel, Sanchez, Ana B, Sánchez-Pavón, Paloma   +5 more
core   +1 more source

Expression of Sprouty 2 in cutaneous squamous cell carcinoma and its relationship with E-cadherin and Ki-67

Pifu-xingbing zhenliaoxue zazhi, 2022
Objective To detect the expression and localization of Sprouty 2, E-cadherin (E-cad) and Ki-67 in skin tissue of squamous cell carcinoma (CSCC), and to analyze the correlation of Sprouty 2 with E-cad and Ki-67.
Chao LI, Wei ZHONG, Lei ZHU, Yuqi HUANG, Jinyi LI, Yongfeng CHEN   +5 more
doaj   +1 more source

Sonic Hedgehog Signaling in Thyroid Cancer

Frontiers in Endocrinology, 2017
Thyroid cancer is the most common malignancy of the endocrine system. The initiation of thyroid cancer is often triggered by a genetic mutation in the phosphortidylinositol-3 kinase (PI3K) or mitogen-activated protein kinase (MAPK) pathway, such as RAS ...
Xiulong Xu, Xiulong Xu, Yurong Lu, Yi Li, Richard A. Prinz   +4 more
doaj   +1 more source

Kaposiform lymphangiomatosis effectively treated with MEK inhibition

EMBO Molecular Medicine, 2020
Kaposiform lymphangiomatosis (KLA) is a rare lymphatic anomaly primarily affecting the mediastinum with high mortality rate. We present a patient with KLA and significant disease burden harboring a somatic point mutation in the Casitas B lineage lymphoma
Jessica B Foster, Dong Li, Michael E March, Sarah E Sheppard, Denise M Adams, Hakon Hakonarson, Yoav Dori   +6 more
doaj   +1 more source

The calcium-sensing receptor as a regulator of cellular fate in normal and pathological conditions [PDF]

, 2013
The calcium-sensing receptor (CaSR) belongs to the evolutionarily conserved family of plasma membrane G protein-coupled receptors (GPCRs). Early studies identified an essential role for the CaSR in systemic calcium homeostasis through its ability to ...
Benoit, Yves, D'Herde, Katharina, Diez Fraile, Araceli, Lammens, Tim   +3 more
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

ERK 1/2 activation does not contribute to increased survival mediated by bone marrow cells after 90% partial hepatectomy in Wistar rats

Clinical and Biomedical Research, 2017
We investigated the influence of bone marrow cells upon activation of ERK ½ in an animal model of 90% PH. Phosphorylated ERK 1/2 was evaluated by western blot. No differences were found between the groups.
Gustavo Alfredo Ochs de Muñoz, Nelson Alexandre Kretzmann, Mónica Luján López, Carlos Oscar Kieling, Carolina Uribe-Cruz, Luciano Basso da Silva, Alessandro Bersch Osvaldt, Ursula da Silveira Matte   +7 more
doaj   +2 more sources