Results 151 to 160 of about 495,928 (201)
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Analysis of MAPK Activities Using MAPK-Specific Antibodies
2014Phosphorylation of proteins by mitogen-activated protein kinases is central to many cellular processes, including signal transduction after stress encounter. Thus, assays to identify or characterize MAP kinase activities are a key tool for research in this area. While in-gel kinase assays using isotope-labeled ATP are a powerful tool to investigate the
Roland, Willmann +2 more
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Current Opinion in Oncology, 2008
As understanding of molecular and genetic processes in cancer evolves, so does appreciation of tumor heterogeneity. Tumor profiling has expanded knowledge of relevant pathways, and their interplay. Similar to the revolution in breast cancer with the discovery and successful therapeutic targeting of HER2/neu, the melanoma field is rapidly evolving.
Leslie A, Fecher +2 more
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As understanding of molecular and genetic processes in cancer evolves, so does appreciation of tumor heterogeneity. Tumor profiling has expanded knowledge of relevant pathways, and their interplay. Similar to the revolution in breast cancer with the discovery and successful therapeutic targeting of HER2/neu, the melanoma field is rapidly evolving.
Leslie A, Fecher +2 more
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Conveying endogenous and exogenous signals: MAPK cascades in plant growth and defense.
Current opinion in plant biology, 2018Mitogen-activated protein kinase (MAPK) cascades are key signaling modules downstream of receptors/sensors that perceive endogenous and exogenous stimuli such as hormones, peptide ligands, and pathogen-derived patterns/effectors.
Mengmeng Zhang +4 more
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American Journal of Physiology-Renal Physiology, 2000
Following an overview of the biochemistry of mitogen-activated protein kinase (MAPK) pathways, the relevance of these signaling events to specific models of renal cell function and pathophysiology, both in vitro and in vivo, will be emphasized. In in vitro model systems, events activating the principal MAPK families [extracellular signal-regulated and ...
W, Tian, Z, Zhang, D M, Cohen
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Following an overview of the biochemistry of mitogen-activated protein kinase (MAPK) pathways, the relevance of these signaling events to specific models of renal cell function and pathophysiology, both in vitro and in vivo, will be emphasized. In in vitro model systems, events activating the principal MAPK families [extracellular signal-regulated and ...
W, Tian, Z, Zhang, D M, Cohen
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Compartmentalised MAPK Pathways
2008The mitogen-activated protein kinase (MAPK) pathway provides cells with the means to interpret external signal cues or conditions, and respond accordingly. This cascade regulates many cell functions such as differentiation, proliferation and migration.
M D, Brown, D B, Sacks
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The Detection of MAPK Signaling
Current Protocols in Cell Biology, 2005AbstractMitogenâactivated protein kinase (MAPK) cascades are central pathways that participate in the intracellular transmission of extracellular signals. Each of the MAPK signaling cascades seems to consist of three to five tiers of protein kinases that sequentially activate each other by phosphorylation.
Yoav, Shaul, Rony, Seger
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ACS Chemical Biology, 2011
The mitogen-activated protein kinase (MAPK) signaling network is integrated into most, if not all, defined homeostatic and regulatory responses of eukaryotic cells. A systematic experimental and computational approach has been used to identify more than 2,000 protein interactions related to functions and regulation of the MAPK signaling network.
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The mitogen-activated protein kinase (MAPK) signaling network is integrated into most, if not all, defined homeostatic and regulatory responses of eukaryotic cells. A systematic experimental and computational approach has been used to identify more than 2,000 protein interactions related to functions and regulation of the MAPK signaling network.
openaire +2 more sources
Kinesins in MAPK cascade: How kinesin motors are involved in the MAPK pathway?
Gene, 2019Kinesins are essential for the transport and positioning of several biomolecules through moving along the microtubule in eukaryotic cells. Up to now, there are 14 kinesin family proteins known.
Ya-Jing Liang, Wan-Xi Yang
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Signal integration by JNK and p38 MAPK pathways in cancer development
Nature Reviews. Cancer, 2009E. Wagner, A. Nebreda
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