Results 161 to 170 of about 381,210 (291)

HSP90AB1‐Mediated Ubiquitin‐Proteasome Degradation of ITGBL1 Promotes Osteosarcoma Progression by Inhibiting Endoplasmic Reticulum Stress‐Induced Autophagy

Advanced Science, EarlyView.
This study delineates a novel HSP90AB1‐ITGBL1 signaling axis governing osteosarcoma. HSP90AB1 promotes K63‐linked ubiquitination and proteasomal degradation of ITGBL1. Restoring ITGBL1 induces reactive oxygen species‐dependent endoplasmic reticulum stress and pro‐death autophagy, suppressing tumor growth and metastasis.
Zhen Wang, Zixuan Guo, Chengwei Cao, Ziying Wang, Zifu Huang, Xiujuan Zhang, Yushu Zheng, Diankun She, Hao Zhu, Lingfeng Yu, Xuelin Zhao, Dongquan Xiang, Song Liao, Xin He, Xintong Ji, Chengsheng Wu, Cheng‐Xiong Xu, Meng Xu   +17 more
wiley   +1 more source

Unpredictable sound stress induces a novel form of hyperalgesic priming. [PDF]

Pain
Araldi D, Green PG, Levine JD.
europepmc   +1 more source

Real‐Time Visualization of Isoform‐Specific RAF‐KRAS Interactions in Living Cells Using FRET‐BRET Hybrid Biosensors

Advanced Science, EarlyView.
Hybrid FRET–BRET biosensors were developed to monitor RAF–KRAS interactions in living cells. These sensors enable real‐time visualization of interaction dynamics, quantitative spectral analysis, and validation of mutation‐selective inhibitors, providing a versatile platform for probing KRAS regulation and therapeutic responses. ABSTRACT The RAS–RAF–MEK–
Jeong‐Min Go, Dahee Lee, Minji Kim, Kiseok Han, Gyuho Choi, ChanHui Song, Sanghyun Ahn, Yerim Lee, Jinyoung Lee, Yingxiao Wang, Jung‐Soo Suh, Hwayoung Yun, Tae‐Jin Kim   +12 more
wiley   +1 more source

Intersection of inflammation and viral replication: the central role of MAPK signaling in viral respiratory infections. [PDF]

Front Microbiol
Tripp RA, Jones LP, Martin DE.
europepmc   +1 more source

Natural Negative Feedback Loops Confer Indica‐Japonica Differentiation for Grain Size Homeostasis in Rice

Advanced Science, EarlyView.
This study reveals the genetic and molecular mechanisms controlling grain size homeostasis through fine‐tuning OsGRX8 self‐expression by two natural negative feedback loops functioning in redox‐dependent or ‐independent manners and identifies two self‐regulatory haplotypes (SRHs) for the subspecies differentiation in rice.
Xingxing Li, Meng‐en Wu, Ziqi Qiao, Junkui Huang, Juncheng Zhang, Yang Ding, Junqing Zhu, Jingyue Xu, Yuxin Huang, Wei Li, Xiaomin Su, Yue Ding, Jianwei Zhang, Yibo Li   +13 more
wiley   +1 more source

Collagen-mediated pro-tumorigenic MAPK activation drives stromal-immune reprogramming in solid cancers. [PDF]

Front Immunol
Ding J, Lin H, Fan H, Xu L, Zhou H, Jiang H, Wang Z, Xia T, Cai Y, Zhu Y, Xu J.   +10 more
europepmc   +1 more source

ER stress induced CCN1 secretion via Ire-1, MAPK, JNK pathways in lung epithelial cells.

, 2015
Moon Hyung-Geun, Zheng Yijie, Hyeok An Chang, Yoon-Keun Kim, Jin Won Yang   +4 more
openalex   +2 more sources

TEF-1 and C/EBPβ are major p38α MAPK-regulated transcription factors in proliferating cardiomyocytes [PDF]

, 2006
Concetta Ambrosino, Tomoko Iwata, Claudio Scafoglio, Massimo Mallardo, Rüdiger Klein, Ángel R. Nebreda   +5 more
openalex   +1 more source

A Testis‐Specific Aralkylamine N‐Acetyltransferase Regulates Dimorphic Sperm Function and Male Fertility in Moths

Advanced Science, EarlyView.
We identify a Lepidoptera‐conserved testis‐specific arylalkylamine N‐acetyltransferase (LTNAT) that governs male moth fertility via a novel mechanism. LTNAT loss disrupts eupyrene sperm mitochondrial derivatives and impairs apyrene sperm motility, offering a safe molecular target for innovative pesticides and genetic pest control.
Hao Sun, Peng‐Yi Huang, Zhi‐Ruo Zhang, Cong‐Fen Gao, Subba Reddy Palli, Shun‐Fan Wu   +5 more
wiley   +1 more source

<i>miR-374b-5p</i> Modulates Melanoma Progression by Targeting VEGFC and Regulating MAPK Signaling in the Tumor Microenvironment. [PDF]

Int J Mol Sci
Chen Z, Liu F, Cheng Y, Li P, Riggs MR, Liu W, Zhu Z.   +6 more
europepmc   +1 more source