Results 161 to 170 of about 514,036 (239)

Chirality Regulates Stem Cell Fate and Promotes Corneal Epithelial Regeneration via Manipulating Notch Pathway

Advanced Science, EarlyView.
Chirality governs the limbal epithelial stem cell fate. Right‐handed chirality enhances cell proliferation and differentiation, while left‐handed chirality partially maintains cell stemness. By activating the Notch pathway, 3D right‐handed chiral hydrogel offers a drug‐free and cell‐free strategy for effective corneal regeneration.
Shiding Li, Yu Zhao, Junzhao Chen, Beibei Wu, Nianxuan Wu, Hao Sun, Liangbo Chen, Chuanliang Feng, Yao Fu   +8 more
wiley   +1 more source

During high salt treatment myeloid p38α/MAPK fosters osteoclast activity and inflammatory macrophage responses promoting orthodontic tooth movement. [PDF]

Front Immunol
Schröder A, Fischer F, Reinert B, Jantsch J, Proff P, Paddenberg-Schubert E, Kirschneck C.   +6 more
europepmc   +1 more source

The Immune Microenvironment: New Therapeutic Implications in Organ Fibrosis

Advanced Science, EarlyView.
This review summarizes recent advances in understanding the immune microenvironment's role in fibrosis, focusing on phenotypic/functional alterations of immune cells and their dynamic interactions with other cellular constituents within tissues. The authors further explore therapeutic opportunities and challenges in targeting immune microenvironment ...
Xiangqi Chen, Chuan Wu, Fei Tang, Jingyue Zhou, Li Mo, Yanping Li, Jinhan He   +6 more
wiley   +1 more source

Research progress and prospect of MAPK signaling pathway in knee osteoarthritis. [PDF]

Eur J Orthop Surg Traumatol
Fan Q, Zhao M, Zhang XD, Chu TY, Kou ZX, Zhao Q.   +5 more
europepmc   +1 more source

Astrocytic ET‐1 System Determines Microglia Phenotype Following Spinal Cord Injury

Advanced Science, EarlyView.
The study reveals that astrocytic ET‐1 system is solely activated by thrombin following SCI via RhoA/NF‐κB and MAPKs/NF‐κB signal pathway. The release of astrocytic ET‐1 drives microglia polarization toward M1 phenotype through YAP signaling via ETA and ETB receptors.
Bingqiang He, Si Xu, Mengdi Li, Hui Li, Shaolan Li, Li Niu, Honghua Song, Rixin Cai, Yue Zhou, Zhilong Cao, Yingjie Wang, Yongjun Wang   +11 more
wiley   +1 more source

Artesunate disrupts germ layer formation by inhibiting BMP signaling pathway. [PDF]

Anim Cells Syst (Seoul)
Kim MS, Yoon GH, Choi SC.
europepmc   +1 more source

Prognostic Value of Serum Insulin‐Like Growth Factor‐1 in Patients With Anal Fistula Treated by Incision‐Thread‐Drawing Surgery

Annals of Gastroenterological Surgery, EarlyView.
IGF‐1 levels above 174.9 ng/mL were associated with better wound healing and lower postoperative inflammation. Higher IGF‐1 levels correlated with improved anal function at 7 and 14 days post‐surgery. ABSTRACT Background Anal fistula is a chronic condition characterized by an abnormal tract between the anal canal and perianal skin, often leading to ...
Zhijun Wu, Xuexue Yin, Jing Li
wiley   +1 more source

Ligand-activated EGFR/MAPK signaling but not PI3K, are key resistance mechanisms to EGFR-therapy in colorectal cancer. [PDF]

Nat Commun
Qu X, Hamidi H, Johnson RM, Sokol ES, Lin E, Eng C, Kim TW, Bendell J, Sivakumar S, Kaplan B, de Sousa E Melo F, Mancini A, Wongchenko M, Shi Y, Shames D, Yan Y, Ciardiello F, Bais C.   +17 more
europepmc   +1 more source

Highly Stable Aggregation‐Induced Emission‐Functionalized Histatin1 Coated With Platelet Vesicles for Diabetic Wound Healing

Aggregate, EarlyView.
Diabetic wound healing is blocked by persistent inflammation and oxidative stress. Bioactive substances like growth factors and Hsts promote repair but lack long‐term stability. Herein, a platelet membrane‐coated nanoparticle system (PNP) is proposed to achieve enhanced retention of aggregation‐induced emissive (AIE) molecular‐modified Hst1 (Hst1‐AIE ...
Xiaoxuan Lei, Judun Zheng, Xu Chen, Liwen Liang, Zhuohong Li, Cancan Huang, Minghai Zhao, Gang Wu, Yuhui Liao, Bin Yang   +9 more
wiley   +1 more source

Shear Wave Elastography: A Non-Invasive Approach for Assessing TGF-β1/MAPK Signaling Molecules and EMT in Breast Cancer. [PDF]

Breast Cancer (Dove Med Press)
Huang S, Wang B, Jiang Y, Li S, Li J, Wang Z.   +5 more
europepmc   +1 more source