Results 171 to 180 of about 514,036 (239)

iPRISM: Intelligent Predicting Response to Cancer Immunotherapy through Systematic Modeling

Advanced Intelligent Systems, EarlyView.
The Intelligent Predicting Response to cancer Immunotherapy through Systematic Modeling (iPRISM) model uses data from genes and immune responses to predict how well cancer patients will respond to immunotherapy. Tested on multiple cancer types, iPRISM shows higher accuracy compared to existing methods.
Yinchun Su, Siyuan Li, Qian Wang, Bingyue Pan, Jiyin Lai, Guangyou Wang, Junwei Han, Qingfei Kong   +7 more
wiley   +1 more source

HPV16 E7 inhibits HBD2 expression by down-regulation of ASK1-p38 MAPK pathway in cervical cancer. [PDF]

Virol J
Liao J, Deng S, Shi B, Wang M, Yin Y, Cao Y, Liu R, Huang X, Jiang L, Shi Q.   +9 more
europepmc   +1 more source

R‐APEX: A Knowledge Graph–Based Platform for the Elucidation of the Toxicological Mechanisms of Ambient Particulate Matter

Advanced Intelligent Systems, EarlyView.
R‐APEX is a knowledge graph platform developed to investigate how air pollutants such as particularly fine particulate matter (PM2.5) affect human health. By integrating large‐scale biomedical data and using machine learning, it reveals pollutant–gene–disease associations.
Zhixing Zhu, Jingcheng Yang, Xiaofei Li, Zhijie Zheng, Georgi Z. Genchev, Yuchen Ye, Liang Liu, Zihan Ran   +7 more
wiley   +1 more source

Genome-wide identification and unveiling the role of MAP kinase cascade genes involved in sugarcane response to abiotic stressors. [PDF]

BMC Plant Biol
Ali A, Zhao XT, Lin JS, Zhao TT, Feng CL, Li L, Wu RJ, Huang QX, Liu HB, Wang JG.   +9 more
europepmc   +1 more source

Costello Syndrome and Ophthalmologic Issues: Unveiling the Unseen

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Costello syndrome (CS) is an ultra‐rare condition belonging to the RASopathies, a group of disorders characterized by aberrant RAS/MAPK pathway signaling, which is involved in ocular development and in some eye pathologies. However, only a few studies assessing the ophthalmic features of individuals with CS are available.
Sofia Peschiaroli, Germana Viscogliosi, Annabella Salerni, Emanuele Crincoli, Roberta Mattei, Tommaso Verdolotti, Serafina Antonella Loprete, Valentina Trevisan, Giovanni Antonio Marrocco, Alessia Cherubino, Lucrezia Perri, Roberta Onesimo, Giuseppe Zampino, Chiara Leoni   +13 more
wiley   +1 more source

HBP-A Attenuates Knee Osteoarthritis Progression via MLK3/P38/HDAC4 Axis-Mediated Dual Protection of Articular Cartilage and Quadriceps. [PDF]

J Cell Mol Med
Wang Z, Huang J, Feng Y, Li Z, Ge H, Wang R, Gu Y, Xiong Y, Chen B, Zhang M, Wang X, Shi Y, Shen Z, Zhan H, Du G.   +14 more
europepmc   +1 more source

Truncating Variants in RREB1 Cause a Novel RASopathy Syndrome of Congenital Heart Disease, Genitourinary Malformations, and Developmental Delay

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT The interstitial 6p microdeletion syndrome is characterized by dysmorphic facies and structural heart, kidney, brain, and musculoskeletal differences. RREB1 haploinsufficiency and consequent abnormal RAS‐MAPK pathway signaling have been proposed as a driver of the disease phenotype; however, apart from a single case report, the phenotype of ...
Alanna Strong, Caoimhe McKenna, Karen Stals, Antonio Vitobello, Mathilde Renaud, Claudine Rieubland, Michel Guipponi, Christophe Philippe, Paul Vrana, Alisa Gaskell, A. Micheil Innes, Alyssa L. Rippert, Rebecca Ahrens‐Nicklas, Elizabeth Bhoj, Kiersten Keller, Bimal P. Chaudhari, Brandon S. Stone   +16 more
wiley   +1 more source

Gossypin induces apoptosis and autophagy via the MAPK/JNK pathway in HT‑29 human colorectal cancer cells. [PDF]

Int J Mol Med
Moon JM, Lee SW, Jang YS, Lee SA, Jung SH, Kim SK, Park BK, Park YS, Kim BS, Yang MS, Jung JY.   +10 more
europepmc   +1 more source

Genomics Review of Selective RET Inhibitors Sensitivity in Thyroid Cancer Clinical Trials

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT RET gene is a driver of thyroid cancer (TC) tumorigenesis. The incidence of TC has increased worldwide in the last few decades, both in medullary and follicular‐derived subtypes. Several drugs, including multikinase and selective inhibitors, have been explored.
Sara Gil‐Bernabé, Lucía García‐DeLaFuente, Alejandro García‐Álvarez, Ginesa García‐Rostán, Jaume Capdevila, Jorge Hernando   +5 more
wiley   +1 more source

Single-cell multi-dimensional data analysis decodes RNF19A-mediated drug resistance in rheumatoid arthritis fibroblast-like synoviocytes: mechanisms and biological insights. [PDF]

Cell Mol Life Sci
Luo X, Tang N, Ren Y, Li J, Zhu H, Wu S, Ding Z.   +6 more
europepmc   +1 more source