Results 91 to 100 of about 303,295 (303)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Peroxiredoxins in Regulation of MAPK Signalling Pathways; Sensors and Barriers to Signal Transduction

Molecules and Cells, 2016
Peroxiredoxins are highly conserved and abundant peroxidases. Although the thioredoxin peroxidase activity of peroxiredoxin (Prx) is important to maintain low levels of endogenous hydrogen peroxide, Prx have also been shown to promote hydrogen peroxide-mediated signalling.
Latimer, Heather R., Veal, Elizabeth A.
openaire   +3 more sources

The pathways enriched in the MAPK signaling pathway (A), apoptosis pathway (B) and hippocampal signaling pathway (C).

, 2015
The pathways enriched in the MAPK signaling pathway (A), apoptosis pathway (B) and hippocampal signaling pathway (C).
Zhen Chen (129176), Weihan Qin (737342), Donghua Zou (290402), Xixia Liu (737341), Yuan Wu (299363), Qi Huang (148030)   +5 more
core   +1 more source

Maternal Wnt/β-catenin signaling coactivates transcription through NF-κB binding sites during Xenopus axis formation. [PDF]

, 2012
Maternal Wnt/β-Catenin signaling establishes a program of dorsal-specific gene expression required for axial patterning in Xenopus. We previously reported that a subset of dorsally expressed genes depends not only on Wnt/β-Catenin stimulation, but also ...
Rupp, Ralph A. W., Armstrong Neil J., Fagotto François, Christian Prothmann, Ralph A W Rupp, Prothmann, Christian, Neil J Armstrong, Rupp Ralph A. W., François Fagotto, Prothmann Christian, Fagotto, François, Armstrong, Neil J.   +11 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

OsEL2 Regulates Rice Cold Tolerance by MAPK Signaling Pathway and Ethylene Signaling Pathway

International Journal of Molecular Sciences
Low temperature stress represents a significant abiotic stress factor affecting rice yields. While the structure and some of the functions of cell cycle protein-dependent protein kinase inhibitor (CKI) family proteins have been the subject of study, their relevance to cold tolerance in rice has been less investigated.
Jiacheng Wu, Xufeng Cao, Xingzhuo Sun, Yulin Chen, Peng Zhang, Yanting Li, Chuan Ma, Lingli Wu, Xin Liang, Qiuping Fu, Lihua Li, Jianqing Zhu, Xiaomei Jia, Xiaoying Ye, Jun Zhu, Rongjun Chen   +15 more
openaire   +2 more sources

VEGFA, MYC, and JUN are abnormally elevated in the synovial tissue of patients with advanced osteoarthritis

Scientific Reports
Osteoarthritis (OA), affecting > 500 million people worldwide, profoundly affects the quality of life and ability to work. The mitogen-activated protein kinase (MAPK) signaling pathway plays an essential role in OA. To address the lack of studies focused
Genxiang Rong, Zhenyu Zhang, Wenjing Zhan, Minnan Chen, Jingjing Ruan, Cailiang Shen   +5 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Impact of Polyphenolic Compounds on MAPK Signaling Pathway against Carcinogenesis

Erciyes Medical Journal, 2023
The mitogen-activated protein kinase (MAPK) signaling pathway is one of the signaling pathways involved in cellular life. Dysregulation of the MAPK signaling pathway is implicated in the emergence of diverse stages of carcinogenesis, including metastasis, angiogenesis, apoptosis, invasion, proliferation and cell differentiation.
openaire   +2 more sources

The two-component sensor kinase TcsC and its role in stress resistance of the human-pathogenic mold Aspergillus fumigatus. [PDF]

, 2012
Two-component signaling systems are widespread in bacteria, but also found in fungi. In this study, we have characterized TcsC, the only Group III two-component sensor kinase of Aspergillus fumigatus. TcsC is required for growth under hyperosmotic stress,
Ilse D. Jacobsen (149635), Beck, Julia, Marzena Broniszewska (160482), Jacobsen, Ilse D., Julia Beck, Beck Julia, Ebel, Frank, Jürgen Heesemann, Allison McCormick, Jacobsen Ilse D., Broniszewska Marzena, Heesemann Jürgen, Ilse D Jacobsen, Broniszewska, Marzena, Frank Ebel (160490), Julia Beck (160485), McCormick Allison, Allison McCormick (160475), Ebel Frank, Frank Ebel, Jürgen Heesemann (4231), Heesemann, Jürgen, Marzena Broniszewska, McCormick, Allison   +23 more
core   +1 more source