Results 31 to 40 of about 7,681 (165)
The therapeutic potential of C-C chemokine receptor antagonists in nonalcoholic steatohepatitis
Exploration of Medicine, 2020 Pooled prevalence of nonalcoholic fatty liver disease (NAFLD) globally is about 25%. Nonalcoholic steatohepatitis (NASH) with advanced fibrosis has been linked with substantial morbidity and mortality, without having to-date any licensed treatment.
Michael Doulberis +4 more
doaj +1 more source
PLoS ONE, 2012 BackgroundInflammation is a key feature of HIV infection and is correlated with long-term negative cardiovascular outcomes. Therapy-induced increases in CD4(+) cell counts can control inflammation, as shown by decreases of coagulation and inflammation ...
Silvia Nozza +7 more
doaj +1 more source
PLoS ONE, 2020 ObjectivesAging HIV-infected antiretroviral-treatment (ART)-controlled patients often present cardiovascular and metabolic comorbidities. Thus, it is mandatory that life-long used ART has no cardiometabolic toxicity.
Martine Auclair +4 more
doaj +1 more source
Pathogens and Immunity, 2017 Background: We aimed to describe the mechanisms of immunological recovery and the effects of blocking CCR5 in patients starting ART with advanced HIV-infection. Methods: Sub-study of a randomized, double-blind, clinical trial where patients starting ART
Pablo Francisco Belaunzarán-Zamudio +10 more
doaj +1 more source
PLoS ONE, 2014 BackgroundThe effect of maraviroc on the maintenance and the function of HIV-1-specific T cell responses remains unknown.MethodsSubjects recently infected with HIV-1 were randomized to receive anti-retroviral treatment with or without maraviroc ...
Ai Kawana-Tachikawa +16 more
doaj +1 more source
Cenicriviroc, a Novel CCR5 (R5) and CCR2 Antagonist, Shows In Vitro Activity against R5 Tropic HIV-2 Clinical Isolates. [PDF]
PLoS ONE, 2015 Maraviroc activity against HIV-2, a virus naturally resistant to different HIV-1 antiretroviral drugs, has been recently demonstrated. The aim of this study was to assess HIV-2 susceptibility to cenicriviroc, a novel, once-daily, dual CCR5 and CCR2 ...
Benoit Visseaux +10 more
doaj +1 more source
Durability and Effectiveness of Maraviroc-Containing Regimens in HIV-1-Infected Individuals with Virological Failure in Routine Clinical Practice. [PDF]
PLoS ONE, 2015 INTRODUCTION:Limited data are available on the durability and effectiveness of maraviroc in routine clinical practice. We assessed the durability of maraviroc-containing regimens during a 30-month period, as well as their immunovirological and clinical ...
Valérie Potard +7 more
doaj +1 more source
Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy
Ibrain, Volume 11, Issue 1, Page 44-58, Spring 2025.In the central nervous system, activated immune cells lead to the overproduction of inflammatory mediators through the corresponding signal pathway. Under the stimulation of inflammatory factors, neuroinflammation ultimately occurs. Overexpression of inflammatory mediators and activated immunocytes plays an important role in the emergence and ...
Yue Yu, Fei‐Ji Sun
wiley +1 more source
Journal of Microbiology, Immunology and InfectionBackground: Therapeutic options for hospitalized people with COVID-19 remain limited, especially for people with non-severe COVID-19 at risk of progression.
Carmen Gasca-Capote +111 more
doaj +1 more source