Results 31 to 40 of about 7,321 (205)

CCR5 is a novel target for the treatment of experimental alopecia areata

Journal of Cutaneous Immunology and Allergy, 2020
Background Alopecia areata (AA) is an organ‐specific and cell‐mediated autoimmune disease. Hair follicle autoantigens are disclosed to these autoreactive NKG2D+CD8+ T cells.
Taisuke Ito, Takahiro Suzuki, Atsuko Funakoshi, Toshiharu Fujiyama, Yoshiki Tokura   +4 more
doaj   +1 more source

HIV antiretroviral drugs, dolutegravir, maraviroc and ritonavir-boosted atazanavir use different pathways to affect inflammation, senescence and insulin sensitivity in human coronary endothelial cells.

PLoS ONE, 2020
ObjectivesAging HIV-infected antiretroviral-treatment (ART)-controlled patients often present cardiovascular and metabolic comorbidities. Thus, it is mandatory that life-long used ART has no cardiometabolic toxicity.
Martine Auclair, Anne-Claire Guénantin, Soraya Fellahi, Marie Garcia, Jacqueline Capeau   +4 more
doaj   +1 more source

Context of maraviroc use.

, 2019
Context of maraviroc use.
Maurizio Zazzi (146810), Nico Pfeifer (45036), Matthias Döring (5953337), Patrizio Pezzotti (804215), Rolf Kaiser (238438), Eugen Schülter (238444), Thomas Lengauer (14699), Charles Boucher (550425), Anna Maria Geretti (7908167), Francesca Incardona (363426), Anne-Mieke Vandamme (7884), Andrea De Luca (132288)   +11 more
core   +1 more source

Levels of soluble endothelial protein C receptor are associated with CD4+ changes in Maraviroc-treated HIV-infected patients.

PLoS ONE, 2012
BackgroundInflammation is a key feature of HIV infection and is correlated with long-term negative cardiovascular outcomes. Therapy-induced increases in CD4(+) cell counts can control inflammation, as shown by decreases of coagulation and inflammation ...
Silvia Nozza, Manuela Pogliaghi, Stefania Chiappetta, Vincenzo Spagnuolo, Gessica Fontana, Cristina Razzari, Giuseppe Tambussi, Elena Maria Faioni   +7 more
doaj   +1 more source

The therapeutic potential of C-C chemokine receptor antagonists in nonalcoholic steatohepatitis

Exploration of Medicine, 2020
Pooled prevalence of nonalcoholic fatty liver disease (NAFLD) globally is about 25%. Nonalcoholic steatohepatitis (NASH) with advanced fibrosis has been linked with substantial morbidity and mortality, without having to-date any licensed treatment.
Michael Doulberis, Kasiani Papadimitriou, Apostolis Papaefthymiou, Jannis Kountouras, Stergios A. Polyzos   +4 more
doaj   +1 more source

Durability and Effectiveness of Maraviroc-Containing Regimens in HIV-1-Infected Individuals with Virological Failure in Routine Clinical Practice. [PDF]

PLoS ONE, 2015
INTRODUCTION:Limited data are available on the durability and effectiveness of maraviroc in routine clinical practice. We assessed the durability of maraviroc-containing regimens during a 30-month period, as well as their immunovirological and clinical ...
Valérie Potard, Jacques Reynes, Tristan Ferry, Céline Aubin, Laurent Finkielsztejn, Yazdan Yazdanpanah, Dominique Costagliola, FHDH ANRS CO4   +7 more
doaj   +1 more source

Immunologic Effects of Maraviroc in HIV-Infected Patients with Severe CD4 Lymphopenia Starting Antiretroviral Therapy: A Sub-Study of the CADIRIS Trial

Pathogens and Immunity, 2017
Background:  We aimed to describe the mechanisms of immunological recovery and the effects of blocking CCR5 in patients starting ART with advanced HIV-infection. Methods: Sub-study of a randomized, double-blind, clinical trial where patients starting ART
Pablo Francisco Belaunzarán-Zamudio, Livio Azzoni, David H. Canaday, Yanink N. Caro-Vega, Brian Clagget, Mohammed S Rassool, Benigno Rodriguez, Ian Sanne, Irini Sereti, Juan G. Sierra-Madero, Michael M. Lederman   +10 more
doaj   +1 more source

A Microbial Lipid‐ATP Synthase Axis Fuels NK Cell Antitumor Activity

Advanced Science, EarlyView.
This study focuses on the mechanism by which gut microbiota‐derived outer membrane vesicles (OMVs) regulate NK cell antitumor activity. B. intestinalis is identified to decrease extra‐intestinal tumor growth via its OMVs enriched in sphingosine (SP).
Kaiyuan Yu, Xinyu Sun, Wanxia Ma, Jianming Yang, Xuan Sun, Lisong Zhang, Yumeng Liu, Tianshu Ren, Qi Wang, Jingyu Wang, Xiao Li, Xianping Peng, Liu Yang, Junqiang Lv, Zhi Yao, Zhi‐Song Zhang, Quan Wang   +16 more
wiley   +1 more source

Enhancing CAR‐T Cell Efficacy in Solid Tumors by Inhibiting CCL5/VEGF‐Mediated Angiogenesis

Advanced Science, EarlyView.
This study reveals that CAR‐T cells in solid tumors produce CCL5, which paradoxically induces VEGF and angiogenesis to promote tumor growth. Blocking CCL5/VEGF signaling—through gene knockout, or the CCR5 inhibitor maraviroc—significantly enhances the antitumor efficacy of CAR‑T therapy (the diagram was created in Biorender).
Shishuo Sun, Qihong Li, Bixi Wang, Gang Wang, Ying Xue, Yibing Liang, Chenhe Hu, Zhenyu Wang, Xiaoge Gao, Haiheng Xu, Jun Song, Hailong Li, Liantao Li, Xiaoxiao Liu, Patrick Ming‐Kuen Tang, Qing Zhang   +15 more
wiley   +1 more source

Maraviroc Pharmacokinetics in HIV-1-Infected Pregnant Women

, 2015
Objective.To describe the pharmacokinetics of maraviroc in human immunodeficiency virus (HIV)-infected women during pregnancy and post partum. Methods.HIV-infected pregnant women receiving maraviroc as part of clinical care had intensive steady-state 12 ...
Van Der Ende, Marchina, Hakim, Alejandro, Knapp, Katherine K.M., Gilleece, Yvonne, Wiznia, Andrew, Alvarez, Janielle Jackson, Colbers, Angela P H, Nellen, Jeannine F J B J., Nicastri, Emanuele, Wride, Thomas, Lewis, Gail, Rockstroh, Jürgen, Tamayo, Vivian, Febo, Irma I.L., Giaquinto, Carlo, Losso, Marcelo, van der Ven, André J A M A.J.A.M., Sadiq, Syed Tariq, Florez, Claudia, Moltó, José, Katz, Mindy, Lambert, John, Deveikis, Audra, Wood, Chris G A C., Jackson, Chivon, Wyen, Christoph, Bruder, Karen K.L., Bryan, Patricia, Erasmus, M., Gingelmaier, Andrea, Auguste, Raphaelle, Faetkenheuer, Gerd, Batra, Jagmohan, Schwarze-Zander, Carolynne, Kabeya, Kabamba, Lyons, F., Buschur, Shelley, Sublette, Nina, Ivalo, Silvina S.A., Stone, Monica, Casey, Denise, Santos, Ruth, Paul, Mary   +42 more
core   +2 more sources