Results 41 to 50 of about 7,681 (165)

Peripheral targets for neuropathic pain

British Journal of Pharmacology, EarlyView.
Neuropathic pain represents a significant clinical challenge, with still limited pharmacological approaches to symptomatic relief. This review focuses on molecular targets implicated in neuropathic pain, particularly those involved in peripheral mechanisms. Using the IUPHAR/BPS database of biological targets, their occurrence together with ‘neuropathic
Amirhossein Afsharipour, Cosmin I. Ciotu, Felix J. Resch, Michael J. M. Fischer   +3 more
wiley   +1 more source

Maraviroc: the first chemokine coreceptor 5 inhibitor

, 2011
HIV viral entry occurs via viral interaction with host cell CD4 receptors and a second coreceptor, most commonly chemokine coreceptor (CCR)5. As a result, CCR5 antagonists have been developed to block HIV entry into CD4+ cells, thereby inhibiting viral ...
Brianna L Norton, Charles B Hicks
core   +1 more source

Short-term maraviroc exposure, a clinical approach to decide on maraviroc prescription in HIV-1-infected treatment-naïve patients.

, 2016
Woollard and Kanmogne1 have generated an exhaustive review on maraviroc and its use in human immunodeficiency virus (HIV) infection. Within their interesting dissertation, they discuss about the maraviroc clinical test (MCT), a clinical approach ...
Gonzalez-Serna, Alejandro, Genebat, Miguel, Ruiz-Mateos, Ezequiel, Leal, Manuel   +3 more
core   +1 more source

Aging of Skeletal Muscle: From Molecular Mechanisms to Therapeutic Interventions

MedComm, Volume 7, Issue 10, October 2026.
Skeletal muscle aging is driven by coordinated local breakdown across myofibers, stem and stromal cells, immune and vascular compartments, and neuromuscular control. These mechanisms promote mitochondrial dysfunction, inflammation, senescence, impaired regeneration, fibrosis, myosteatosis, denervation, and functional decline.
Ting Liu, Yaomin Hu
wiley   +1 more source

Activity of Maraviroc in PBMC.

, 2013
In vitro efficacy of Maraviroc in PBMC cultures. The histogram represents the percentage of viral inhibition (p24 production pg/ml) in presence of Maraviroc, AMD3100 and AZT at different concentrations, considering the untreated as 100. Mean values of at
Patrizia Saccomandi (431861), Stefano Aquaro (82885), Matteo Surdo (431859), Emanuela Balestra (431860), Marco Montano (431863), Carlo Federico Perno (103671), Fabiola Di Santo (431862), Valentina Svicher (103599), Domenico Di Carlo (431864), Massimo Andreoni (103649), Francesca Ceccherini-Silberstein (103660), Loredana Sarmati (431865)   +11 more
core   +1 more source

Evasins: Biology and Therapeutic Potential of Broad‐Spectrum Chemokine Inhibitors

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 4, October 2026.
ABSTRACT Ticks are haematophagous parasites that rely on uninterrupted bloodmeals for survival and need an effective strategy to suppress the host inflammatory response. Leukocyte recruitment is a chemokine‐mediated hallmark of inflammation, which ticks counteract via anti‐chemokine proteins in their saliva named evasins.
Emilia L. Bialek, Roos Buds, Ingrid Dijkgraaf, Pedro E. Marques   +3 more
wiley   +1 more source

HIV-1 Entry, Inhibitors, and Resistance

Viruses, 2010
Entry inhibitors represent a new class of antiretroviral agents for the treatment of infection with HIV-1. While resistance to other HIV drug classes has been well described, resistance to this new class is still ill defined despite considerable clinical
Michael A. Lobritz, Annette N. Ratcliff, Eric J. Arts   +2 more
doaj   +1 more source

CCR5 antagonist reduces HIV-induced amyloidogenesis, tau pathology, neurodegeneration, and blood-brain barrier alterations in HIV-infected hu-PBL-NSG mice

Molecular Neurodegeneration, 2021
Background Neurocognitive impairment is present in 50% of HIV-infected individuals and is often associated with Alzheimer’s Disease (AD)-like brain pathologies, including increased amyloid-beta (Aβ) and Tau hyperphosphorylation.
Biju Bhargavan, Shawna M. Woollard, Jo Ellyn McMillan, Georgette D. Kanmogne   +3 more
doaj   +1 more source

Enzyme Responsive Vaginal Microbicide Gels Containing Maraviroc and Tenofovir Microspheres Designed for Acid Phosphatase-Triggered Release for Pre-Exposure Prophylaxis of HIV-1: A Comparative Analysis of a Bigel and Thermosensitive Gel

Gels, 2021
The challenges encountered with conventional microbicide gels has necessitated the quest for alternative options. This study aimed to formulate and evaluate a bigel and thermosensitive gel, designed to combat the challenges of leakage and short-residence
Sabdat Ozichu Ekama, Margaret O. Ilomuanya, Chukwuemeka Paul Azubuike, James Babatunde Ayorinde, Oliver Chukwujekwu Ezechi, Cecilia Ihuoma Igwilo, Babatunde Lawal Salako   +6 more
doaj   +1 more source

Cerebrospinal fluid maraviroc concentrations in HIV-1 infected patients

, 2009
In order to assess the penetration of maraviroc to the central nervous system, we measured maraviroc concentrations in cerebrospinal fluid (CSF) and plasma.
Else, L, Gisslén, Magnus,, Watson, V, Yilmaz, Aylin,   +3 more
core   +1 more source