Results 41 to 50 of about 7,321 (205)
Journal of Microbiology, Immunology and InfectionBackground: Therapeutic options for hospitalized people with COVID-19 remain limited, especially for people with non-severe COVID-19 at risk of progression.
Carmen Gasca-Capote +111 more
doaj +1 more source
Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy
Ibrain, Volume 11, Issue 1, Page 44-58, Spring 2025.In the central nervous system, activated immune cells lead to the overproduction of inflammatory mediators through the corresponding signal pathway. Under the stimulation of inflammatory factors, neuroinflammation ultimately occurs. Overexpression of inflammatory mediators and activated immunocytes plays an important role in the emergence and ...
Yue Yu, Fei‐Ji Sun
wiley +1 more source
Maraviroc: the first chemokine coreceptor 5 inhibitor
, 2011 HIV viral entry occurs via viral interaction with host cell CD4 receptors and a second coreceptor, most commonly chemokine coreceptor (CCR)5. As a result, CCR5 antagonists have been developed to block HIV entry into CD4+ cells, thereby inhibiting viral ...
Brianna L Norton, Charles B Hicks
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Gels, 2021 The challenges encountered with conventional microbicide gels has necessitated the quest for alternative options. This study aimed to formulate and evaluate a bigel and thermosensitive gel, designed to combat the challenges of leakage and short-residence
Sabdat Ozichu Ekama +6 more
doaj +1 more source
Chiral (Stereoselective) Drugs, Asymmetric Synthesis, and Racemic Resolution Methods
Chirality, Volume 38, Issue 7, July 2026.Chirality is crucial in drug development since both biological targets in the organism and the majority of pharmaceutical compounds are chiral. The synthesis and resolution of chiral compounds are critical steps while developing chiral drugs. Asymmetric synthesis and racemic resolution are the two most common methods for obtaining enantiopure drugs ...
Burcu Karayavuz +1 more
wiley +1 more source
, 2016 Woollard and Kanmogne1 have generated an exhaustive review on maraviroc and its use in human immunodeficiency virus (HIV) infection. Within their interesting dissertation, they discuss about the maraviroc clinical test (MCT), a clinical approach ...
Gonzalez-Serna, Alejandro +3 more
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Molecular Neurodegeneration, 2021 Background Neurocognitive impairment is present in 50% of HIV-infected individuals and is often associated with Alzheimer’s Disease (AD)-like brain pathologies, including increased amyloid-beta (Aβ) and Tau hyperphosphorylation.
Biju Bhargavan +3 more
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T‐Cell Biology in the Female Reproductive Tract: Relevance to HIV Infection
American Journal of Reproductive Immunology, Volume 95, Issue 6, June 2026.ABSTRACT Worldwide, most HIV infections occur across a mucosal surface during sexual contact, with women accounting for nearly half of reported new HIV infections across the globe in 2024. Most new infections in women and girls are believed to involve transmission across mucosal surfaces of the lower reproductive tract, which includes the vagina and ...
Barbara L. Shacklett +2 more
wiley +1 more source
Activity of Maraviroc in PBMC.
, 2013 In vitro efficacy of Maraviroc in PBMC cultures. The histogram represents the percentage of viral inhibition (p24 production pg/ml) in presence of Maraviroc, AMD3100 and AZT at different concentrations, considering the untreated as 100. Mean values of at
Patrizia Saccomandi (431861) +11 more
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Demographic information for ENLIGHTEN maraviroc DOT study participants.
, 2023 Demographic information for ENLIGHTEN maraviroc DOT study participants.
Elias P. Rosen (1430320) +8 more
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