Results 41 to 50 of about 6,076,506 (176)

Forty-Five Years of Marburg Virus Research

Viruses, 2012
In 1967, the first reported filovirus hemorrhagic fever outbreak took place in Germany and the former Yugoslavia. The causative agent that was identified during this outbreak, Marburg virus, is one of the most deadly human pathogens.
Kristina Brauburger, Adam J. Hume, Judith Olejnik, Elke Mühlberger   +3 more
doaj   +1 more source

Computed Tomography Imaging for Monitoring of Marburg Virus Disease: a Nonhuman Primate Proof-Of-Concept Study

Microbiology Spectrum, 2023
Marburg virus (MARV) is a highly virulent zoonotic filovirid that causes Marburg virus disease (MVD) in humans. The pathogenesis of MVD remains poorly understood, partially due to the low number of cases that can be studied, the absence of state-of-the ...
Jennifer Sword, Ji Hyun Lee, Marcelo A. Castro, Jeffrey Solomon, Nina Aiosa, Syed M. S. Reza, Winston T. Chu, Joshua C. Johnson, Christopher Bartos, Kurt Cooper, Peter B. Jahrling, Reed F. Johnson, Claudia Calcagno, Ian Crozier, Jens H. Kuhn, Lisa E. Hensley, Irwin M. Feuerstein, Venkatesh Mani   +17 more
doaj   +1 more source

A retrospective cohort investigation of seroprevalence of Marburg virus and ebolaviruses in two different ecological zones in Uganda

BMC Infectious Diseases, 2020
Background Uganda has experienced seven Ebola Virus Disease (EVD) outbreaks and four Marburg Virus Disease (MVD) outbreaks between 2000 and 2019. We investigated the seroprevalence and risk factors for Marburg virus and ebolaviruses in gold mining ...
Luke Nyakarahuka, Ilana J. Schafer, Stephen Balinandi, Sophia Mulei, Alex Tumusiime, Jackson Kyondo, Barbara Knust, Julius Lutwama, Pierre Rollin, Stuart Nichol, Trevor Shoemaker   +10 more
doaj   +1 more source

The Cytoplasmic MicroRNA‐Production Complex Regulates MicroRNA Sorting to Extracellular Vesicles During Synaptogenesis

Advanced Science, EarlyView.
The mechanisms of microRNA cargo sorting to extracellular vesicles, important mediators of cell communication, are not fully understood. This study reveals that the microRNA‐production machinery acts as a ‘hub’ for the sorting of microRNAs to extracellular vesicles, a process regulated by dynamic organelle interactions.
Yuzhou Zeng, Selina Luhmann, Aditi Saha, Marta Orlando, Haider Sami, Timo Glatter, Anna Antoniou   +6 more
wiley   +1 more source

Use of protective gear and the occurrence of occupational Marburg hemorrhagic fever in health workers from Watsa health zone, Democratic Republic of the Congo.

, 2007
BACKGROUND: Occupational transmission to health workers (HWs) has been a typical feature of Marburg hemorrhagic fever (MHF) outbreaks. The goal of this study was to identify cases of occupational MHF in HWs from Durba and Watsa, Democratic Republic of ...
Libande, Modeste L, MULANGU, S, TSHOMBA, A, Pierre Lefèvre, Muyembe-Tamfum, J. J., Van der Stuyft, Patrick, LIBANDE, ML, Muyembe-Tamfum, Jean-Jacques, Kulidri, Amayo, Tshomba, Antoine, MUYEMBE-TAMFUM, JJ, BORCHERT, M, Antoine Tshomba, Borchert, M., Tshomba, A., Van der Stuyft, P., Libande, M. L., Jean‐Jacques Muyembe‐Tamfum, Modeste L. Libande, Kulidri, A., Amayo Kulidri, Matthias Borchert, Mulangu, Sabue, Mulangu, S., LEFEVRE, P, Sabue Mulangu, KULIDRI, A, Patrick Van der Stuyft, Borchert, Matthias, Lefevre, Pierre, Lefèvre, P.   +30 more
core   +1 more source

Marburg virus: an emerging global threat

Journal of Zoonotic Diseases
Marburg virus disease is a rare, but severe illness caused by highly pathogenic Marburg virus, a member of the Filoviridae family. The virus was first identified in 1967 in Marburg and Frankfurt, Germany, as well as Belgrade, Serbia.
Balamurugan Shanmugaraj
doaj   +1 more source

Experimental Vaccines for Prevention of Marburg Hemorrhagic Fever and Animal Models for Studying Pathogenesis

Проблемы особо опасных инфекций, 2018
Marburg fever is an acute natural-focal disease characterized by severe course, hemorrhagic syndrome, high level of contagiousness and lethality. The causative agent of the disease is the RNA-containing virus belonging to the family of filoviruses ...
N. V. Volkova, E. I. Kazachinskaya, D. N. Shcherbakov   +2 more
doaj   +1 more source

Safety and pharmacokinetics of inhaled aloxistatin: A first‐in‐human phase 1 dose escalation trial

British Journal of Clinical Pharmacology, EarlyView.
Aims Aloxistatin (E64d) is a membrane‐permeable cysteine protease inhibitor prodrug that is converted by esterases to the active metabolite E64c (loxistatin). This first‐in‐human study evaluated the safety, tolerability and pharmacokinetics of single ascending doses of inhaled E64d in healthy volunteers.
Sebastian Fähndrich, Franziska Friedrich, Daniel Soriano, Jona Gjeloshi, Björn C. Frye, Xuan Phuoc Nguyen, Lydia Herbstritt, Caroline von Spee‐Mayer, Britta Lang, Fabrice Nollevaux, Andreas Hoheisel, Dorothee Winterberg, Armin Braun, Thomas Epting, Christine Contini, Karl Winkler, Thomas Reinheckel, Franziska C. Trudzinski, Gernot Rohde, Daiana Stolz, Robert Bals, Martin J. Hug, Sebastian Wirtz, Christoph Peters, Carolin Jenkner   +24 more
wiley   +1 more source

Everyone Knows It's a Hoax: The Role of Perceived Descriptive Norms in Conspiracy Beliefs

European Journal of Social Psychology, EarlyView.
ABSTRACT People's belief in conspiracy theories is shaped by social influence processes. This contribution investigated these processes in six studies (total N = 2906) by examining the role of descriptive norms, that is, the perception that others endorse conspiracy theories.
Jan‐Willem van Prooijen, Paul K. Bergmann, Vladimira Čavojová, Jakub Šrol   +3 more
wiley   +1 more source

How severe and prevalent are Ebola and Marburg viruses? A systematic review and meta-analysis of the case fatality rates and seroprevalence

BMC Infectious Diseases, 2016
Background Ebola and Marburg virus diseases are said to occur at a low prevalence, but are very severe diseases with high lethalities. The fatality rates reported in different outbreaks ranged from 24–100%.
Luke Nyakarahuka, Clovice Kankya, Randi Krontveit, Benjamin Mayer, Frank N. Mwiine, Julius Lutwama, Eystein Skjerve   +6 more
doaj   +1 more source