Marburg virus outbreaks in Africa
Marburg virus disease (MVD) is a zoonotic viral hemorrhagic illness, caused by a negative sense, single-stranded RNA virus which has an envelope. The Marburg virus belongs to the genus Marburgvirus of the family Filoviridae.
Ibrahim Idris +2 more
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Treatment of Marburg and Ebola hemorrhagic fevers: A strategy for testing new drugs and vaccines under outbreak conditions. [PDF]
The filoviruses, Marburg and Ebola, have the dubious distinction of being associated with some of the highest case-fatality rates of any known infectious disease-approaching 90% in many outbreaks.
A.G. Sprecher +105 more
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Marburg and Ebola Virus Infections Elicit a Complex, Muted Inflammatory State in Bats
The Marburg and Ebola filoviruses cause a severe, often fatal, disease in humans and nonhuman primates but have only subclinical effects in bats, including Egyptian rousettes, which are a natural reservoir of Marburg virus.
Anitha D. Jayaprakash +11 more
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Isolation of Angola-like Marburg virus from Egyptian rousette bats from West Africa. [PDF]
Marburg virus (MARV) causes sporadic outbreaks of severe Marburg virus disease (MVD). Most MVD outbreaks originated in East Africa and field studies in East Africa, South Africa, Zambia, and Gabon identified the Egyptian rousette bat (ERB; Rousettus ...
Amara, Emmanuel +49 more
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Marburg Virus Disease – A Mini-Review
Marburg virus disease (MVD) is a highly fatal disease caused by the Marburg virus (MARV) which belongs to the family Filoviridae. The disease has been recently reported from Ghana, an African country, and nearly 15 outbreaks of MVD have been reported in the past five decades. Various species of bats viz., Rousettus aegyptiacus, Hipposideros caffer, and
Sandip Chakraborty +7 more
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Ghana, a country in the African continent experienced its first ever outbreak of Marburg Virus disease on July 2022. Prior to this, Democratic Republic of Congo and Angola were the two most severely affected countries to be affected by the same disease ...
Ranjit Sah +6 more
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Lyophilisation of influenza, rabies and Marburg lentiviral pseudotype viruses for the development and distribution of a neutralisation-assay based diagnostic kit [PDF]
Pseudotype viruses (PVs) are chimeric, replication-deficient virions that mimic wild-type virus entry mechanisms and can be safely employed in neutralisation assays, bypassing the need for high biosafety requirements and performing comparably to ...
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Approaches to demonstrating the effectiveness of filovirus vaccines: Lessons from Ebola and COVID-19
Zaire ebolavirus (EBOV), Sudan ebolavirus (SUDV) and Marburg virus (MARV), are members of the Filoviridae family that can cause severe disease and death in humans and animals.
Marion F. Gruber +2 more
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Case Series of Patients with Marburg Virus Disease, Equatorial Guinea, 2023. [PDF]
Fontana L +24 more
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Ebola virus VP30 and nucleoprotein interactions modulate viral RNA synthesis [PDF]
Ebola virus (EBOV) is an enveloped negative-sense RNA virus that causes sporadic outbreaks with high case fatality rates. Ebola viral protein 30 (eVP30) plays a critical role in EBOV transcription initiation at the nucleoprotein (eNP) gene, with ...
Amarasinghe, Gaya K +6 more
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