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Protection Against Marburg Virus Using a Recombinant VSV-Vaccine Depends on T and B Cell Activation [PDF]

Frontiers in Immunology, 2019
Marburg virus (MARV) is the causative agent of hemorrhagic fever outbreaks with high case fatality rates. Closely related to Ebola virus, MARV is a filamentous virus with a negative-sense, single-stranded RNA genome.
Andrea Marzi, Andrea R. Menicucci, Flora Engelmann, Julie Callison, Eva J. Horne, Friederike Feldmann, Allen Jankeel, Heinz Feldmann, Ilhem Messaoudi   +8 more
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Virulence of Marburg Virus Angola Compared to Mt. Elgon (Musoke) in Macaques: A Pooled Survival Analysis

Viruses, 2018
Angola variant (MARV/Ang) has replaced Mt. Elgon variant Musoke isolate (MARV/MtE-Mus) as the consensus standard variant for Marburg virus research and is regarded as causing a more aggressive phenotype of disease in animal models; however, there is a ...
Paul W. Blair, Maryam Keshtkar-Jahromi, Kevin J. Psoter, Ronald B. Reisler, Travis K. Warren, Sara C. Johnston, Arthur J. Goff, Lydia G. Downey, Sina Bavari, Anthony P. Cardile   +9 more
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Isolation of Angola-like Marburg virus from Egyptian rousette bats from West Africa [PDF]

Nature Communications, 2020
Egyptian rousette bats (ERBs) are natural reservoirs for Marburg virus (MARV), but these bats have not been linked to the MARV Angola strain that caused the largest and deadliest outbreak on record.
Brian R. Amman, Brian H. Bird, Ibrahim A. Bakarr, James Bangura, Amy J. Schuh, Jonathan Johnny, Tara K. Sealy, Immah Conteh, Alusine H. Koroma, Ibrahim Foday, Emmanuel Amara, Abdulai A. Bangura, Aiah A. Gbakima, Alexandre Tremeau-Bravard, Manjunatha Belaganahalli, Jasjeet Dhanota, Andrew Chow, Victoria Ontiveros, Alexandra Gibson, Joseph Turay, Ketan Patel, James Graziano, Camilla Bangura, Emmanuel S. Kamanda, Augustus Osborne, Emmanuel Saidu, Jonathan Musa, Doris Bangura, Samuel Maxwell Tom Williams, Richard Wadsworth, Mohamed Turay, Lavalie Edwin, Vanessa Mereweather-Thompson, Dickson Kargbo, Fatmata V. Bairoh, Marilyn Kanu, Willie Robert, Victor Lungai, Raoul Emeric Guetiya Wadoum, Moinya Coomber, Osman Kanu, Amara Jambai, Sorie M. Kamara, Celine H. Taboy, Tushar Singh, Jonna A. K. Mazet, Stuart T. Nichol, Tracey Goldstein, Jonathan S. Towner, Aiah Lebbie   +49 more
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Bioinformatic, Biochemical, and Immunological Mining of MHC Class I Restricted T Cell Epitopes for a Marburg Nucleoprotein Microparticle Vaccine [PDF]

Vaccines
The Marburg virus (MARV), the virus responsible for Marburg hemorrhagic fever (MHF), is considered a top-priority pathogen for vaccine development. Recent outbreaks in Equatorial Africa have highlighted the urgency of MARV because of its high fatality ...
Paul E. Harris, Scott Burkholz, Charles V. Herst, Reid M. Rubsamen   +3 more
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Coordinated inflammatory responses dictate Marburg virus control by reservoir bats [PDF]

Nature Communications
Bats are increasingly recognized as reservoirs of emerging zoonotic pathogens. Egyptian rousette bats (ERBs) are the known reservoir of Marburg virus (MARV), a filovirus that causes deadly Marburg virus disease (MVD) in humans.
Jonathan C. Guito, Shannon G. M. Kirejczyk, Amy J. Schuh, Brian R. Amman, Tara K. Sealy, James Graziano, Jessica R. Spengler, Jessica R. Harmon, David M. Wozniak, Joseph B. Prescott, Jonathan S. Towner   +10 more
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Egyptian rousette bats maintain long-term protective immunity against Marburg virus infection despite diminished antibody levels

Scientific Reports, 2017
Although bats are natural reservoir hosts for numerous zoonotic viruses, little is known about the long-term dynamics of the host immune response following infection and how these viruses are maintained in nature.
Amy J. Schuh, Brian R. Amman, Tara K. Sealy, Jessica R. Spengler, Stuart T. Nichol, Jonathan S. Towner   +5 more
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Can Marburg virus be sexually transmitted?

Health Science Reports
Background and Aim Marburg virus (MARV) is a highly virulent virus of animal origin and the cause of a lethal infection (known as Marburg virus disease [MVD]) with a case‐fatality ratio ranging from 24% to 90%.
Hassan Karami, Arash Letafati, Somayeh Sadat Hosseini Fakhr   +2 more
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Marburg Virus Glycoprotein Is a Remarkable Virulent Factor Linked to Hemorrhagic Pathology: Evidence from Multimodal Experimental Systems [PDF]

Advanced Science
Marburg virus (MARV) causes Marburg virus disease (MVD), a severe hemorrhagic fever associated with high morbidity and mortality. No specific antiviral therapies are currently approved for MVD, and viral pathogenesis, particularly the viral pathogenic ...
Ting Yao, Hang Liu, Yanfeng Yao, Wei Deng, Jiawen Sun, Zhenyu Kang, Ashaq Ali, Chao Shan, Zhiming Yuan, Fei Deng, Hualin Wang, Yun‐Jia Ning   +11 more
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Rapid Development of Modified Vaccinia Virus Ankara (MVA)-Based Vaccine Candidates Against Marburg Virus Suitable for Clinical Use in Humans

Vaccines
Background/Objectives: Marburg virus (MARV) is the etiological agent of Marburg Virus Disease (MVD), a rare but severe hemorrhagic fever disease with high case fatality rates in humans.
Alina Tscherne, Georgia Kalodimou, Alexandra Kupke, Cornelius Rohde, Astrid Freudenstein, Sylvia Jany, Satendra Kumar, Gerd Sutter, Verena Krähling, Stephan Becker, Asisa Volz   +10 more
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A bioluminescent imaging mouse model for Marburg virus based on a pseudovirus system

Human Vaccines & Immunotherapeutics, 2017
Marburg virus (MARV) can cause lethal hemorrhagic fever in humans. Handling of MARV is restricted to high-containment biosafety level 4 (BSL-4) facilities, which greatly impedes research into this virus.
Li Zhang, Qianqian Li, Qiang Liu, Weijin Huang, Jianhui Nie, Youchun Wang   +5 more
doaj   +2 more sources