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A study of vaccination against Marek's disease with an attenuated Marek's disease virus

Avian Pathology, 1974
Approximately 2,000 day-old white leghorn chickens were distributed into 10 pens and half the pens vaccinated with the attenuated strain of HPRS-16. At 72 weeks of age, mortality from non-specific death and Marek's disease was 17.6% and 15.6% respectively, in vaccinated chickens compared with 14.2% and 51.7% in unvaccinated chickens.
C A, Jackson   +4 more
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Cyclophosphamide-Induced Amelioration of Marek's Disease in Marek's Disease-Susceptible Chickens

American Journal of Veterinary Research, 1976
SUMMARY Bursa- and thymus-dependent functions were examined in Marek's disease (md)-susceptible normal chickens and in chickens treated with 5 and 16 mg of cyclophosphamide (cy) at the time of hatching. Chickens not exposed to Marek's disease virus (mdv) and treated with cy temporarily lost mitogenic response to concanavalin A but regained full ...
Y S, Lu, V, Kermani-Arab, T, Moll
openaire   +2 more sources

Herpesvirus in Marek's Disease Tumors

Science, 1969
Intranuclear and cytoplasmic virus particles of the herpes type were located in epithelial cells that line the kidney collecting tubules obtained from a chick with Marek's disease. The chick had contracted the disease by direct contact transmission. The virus was not observed in any of the invading tumor cells in the same kidney.
G, Schidlovsky, M, Ahmed, K E, Jensen
openaire   +2 more sources

Hematopoietic Destruction in Marek's Disease

Avian Diseases, 1970
Hematopoietic destructive lesions, characterized by necrosis and loss of architecture in the bursa of Fabricius and thymus, were observed consistently in second-generation specific-pathogen-free X Line 7 (SPF X L7-F2) cross chickens inoculated at 1 day with an acute form of Marek's disease (MD) agent.
R M, Jakowski   +3 more
openaire   +2 more sources

Genomics and Marek’s disease virus

Cytogenetic and Genome Research, 2007
Marek’s disease virus (MDV), a lymphotrophic alphaherpesvirus of chickens, causes a disease that is characterized by tumor formation, immunosuppression and neurological disorders. Recent developments in chicken genomics have been applied to studies of MDV and have advanced our understanding of both the virus and the disease it causes.
J, Burnside, R W, Morgan
openaire   +2 more sources

Genetic Resistance to Marek’s Disease

2001
Marek’s disease (MD) is economically one of the most significant diseases in chickens (Purchase 1985). It is of interest that numerous estimates of heritability of resistance to MD are relatively high compared to the resistance to other diseases in chickens or other diseases in domestic livestock.
L D, Bacon, H D, Hunt, H H, Cheng
openaire   +2 more sources

Latency and Tumorigenesis in Marek's Disease

Avian Diseases, 2013
Despite the remarkable progress in our understanding of Marek's disease (MD) and the causative Marek's disease virus (MDV) biology, a number of major features of this complex viral disease remain unknown. Significant information on critical aspects of virus latency in lymphoid cells, and the virus-host interaction in MDV-induced lymphoma, remains to be
openaire   +2 more sources

Immunization against Marek's Disease

Avian Diseases, 1971
The turkey herpesvirus (HVT) and Marek's disease (MDHV) herpesvirus produce a similar virus-like cytopathic effect in monolayers of chick embryo fibroblasts. Discrete foci of rounded refractile cells and syncytial masses with some of the nuclei containing Cowdry type A inclusions were observed in affected monolayers.
C S, Eidson, D P, Anderson
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Immune mechanisms in marek's disease

Comparative Immunology, Microbiology and Infectious Diseases, 1979
Resistance to progressive tumor development in MD is either naturally inherited or can be induced by vaccination with apathogenic or attenuated MDV or with HVT. Studies on the effects of immunosuppression on resistance have shown that natural and vaccine induced resistance may be mediated through immune responses.
J M, Sharma, B R, Burmester
openaire   +2 more sources

Marek's disease vaccination of chickens

Australian Veterinary Journal, 1996
Interpretive summaries of interesting articles on veterinary pharmacology are provided by the Pharmacology Chapter of the Australian College of Veterinary ...
openaire   +4 more sources

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