Results 31 to 40 of about 1,753 (134)

Impact of Resolvin-E1 and Maresin-1 on Bone Marrow Stem Cell Osteogenesis under Inflammatory Stress [PDF]

Cells
Periodontal disease is characterized by inflammation and bone loss. Central to its pathogenesis is the dysregulated inflammatory response, complicating regenerative therapies.
Shahd AlZahrani, Zakia Shinwari, Ayodele Alaiya, Ahmed Al-Kahtani   +3 more
doaj   +2 more sources

Satellite glial GPR37L1 and its ligand maresin 1 regulate potassium channel signaling and pain homeostasis [PDF]

The Journal of Clinical Investigation
G protein–coupled receptor 37-like 1 (GPR37L1) is an orphan GPCR with largely unknown functions. Here, we report that Gpr37l1/GRP37L1 ranks among the most highly expressed GPCR transcripts in mouse and human dorsal root ganglia (DRGs) and is selectively ...
Sangsu Bang, Changyu Jiang, Jing Xu, Sharat Chandra, Aidan McGinnis, Xin Luo, Qianru He, Yize Li, Zilong Wang, Xiang Ao, Marc Parisien, Lorenna Oliveira Fernandes de Araujo, Sahel Jahangiri Esfahani, Qin Zhang, Raquel Tonello, Temugin Berta, Luda Diatchenko, Ru-Rong Ji   +17 more
doaj   +2 more sources

Maresin 1 Ameliorates Diabetic Kidney Disease in Mice by Promoting Macrophage M2 Polarization [PDF]

Mediators of Inflammation
Yueli Pu, Xiumei Ma, Kang Geng, Renliang Meng, Yonglin Li, Chunmei Zheng, Changying Zhao, Fangyuan Teng, Yong Xu   +8 more
doaj   +2 more sources

Maresin 1 modulates renal and cardiac lipid profiles in hypertensive rats. [PDF]

Am J Physiol Renal Physiol
This study shows that MaR1, a specialized proresolving mediator, influences lipid metabolism and modifies gene expression in the heart and kidney in a salt-sensitive hypertension model, without affecting blood pressure or organ structure. These findings highlight the potential role of MaR1 in regulating inflammation and circadian rhythms associated ...
Bohovyk R, Kravtsova O, Upadhyay G, Levchenko V, Lowe M, Shapiro A, Halade GV, Staruschenko A.   +7 more
europepmc   +3 more sources

Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction‐associated fatty liver disease

Hepatology, EarlyView., 2022
Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario, David Sebastián, Mireia Casulleras, Marta Duran‐Güell, Roger Flores‐Costa, Ferran Aguilar, Juan José Lozano, Ingrid W. Zhang, Esther Titos, Jing X. Kang, Antonio Zorzano, Makoto Arita, Joan Clària   +12 more
wiley   +1 more source

Cetirizine and Dexamethasone in Sepsis: Insights into Maresin-1 Signaling and Cytokine Regulation. [PDF]

J Clin Med
Background/Objectives: Sepsis remains one of the leading causes of mortality, yet its etiopathogenesis is still not fully understood. This study aimed to investigate the effects of cetirizine and dexamethasone (alone and in combination) on serum levels of Maresin-1 (MaR-1), TNF-α, IFN-γ, IL-1, IL-2, IL-6, IL-8, and IL-10 in a rat model of sepsis ...
Aydin Y, Borku MK, Ugur K, Eroksuz Y, Emre E, Incili CA, Sahin İ, Acarturk İZ, Aydin S, Lee DY.   +9 more
europepmc   +4 more sources

Blood, saliva and urine maresin-1 and malondialdehyde may be useful biomarker in patients with polycystic ovary syndrome: a prospective study

Clinical and Experimental Obstetrics & Gynecology, 2022
Background: Maresin-1 (MaR1) plays a major role in many inflammatory disorders. Polycystic ovary syndrome (PCOS) aside from a hormonal disorder, an inflammation might also contribute to PCOS and its metabolic associations.
Adem Yavuz, Kader Ugur, Zuhal Karaca Karagoz, Durmus Ayan, Suleyman Aydin   +4 more
doaj   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Identification and Actions of the Maresin 1 Metabolome in Infectious Inflammation [PDF]

The Journal of Immunology, 2016
Abstract Maresin 1 (MaR1) is an immunoresolvent that governs resolution of acute inflammation, and its local metabolism in the context of infectious inflammation is of interest. In this study, we investigated the MaR1 metabolome in infectious exudates and its bioactions in regulating leukocyte responses in the context of bacterial ...
Romain A Colas, Jesmond Dalli, Nan Chiang, Iliyan Vlasakov, Julia M Sanger, Ian R Riley, Charles N Serhan   +6 more
openaire   +3 more sources

The Maresin 1-LGR6 axis decreases respiratory syncytial virus-induced lung inflammation. [PDF]

Proc Natl Acad Sci U S A, 2023
The resolution of infection is an active process with specific molecular and cellular mechanisms that temper inflammation and enhance pathogen clearance. Here, the specialized pro-resolving mediator (SPM) Maresin 1 (MaR1) inhibited respiratory syncytial virus (RSV)-induced inflammation.
Krishnamoorthy N, Walker KH, Brüggemann TR, Tavares LP, Smith EW, Nijmeh J, Bai Y, Ai X, Cagnina RE, Duvall MG, Lehoczky JA, Levy BD.   +11 more
europepmc   +3 more sources