12‑weeks fisetin supplementation and interval resistance with aerobic training: changes in Maresin‑1 and inflammatory markers in men with obesity: a randomized controlled trial [PDF]
Journal of the International Society of Sports NutritionBackground Obesity is characterized by low‑grade chronic inflammation and impaired insulin sensitivity. Maresin‑1 (MaR1), a specialized pro‑resolving mediator, plays a critical role in terminating inflammation and supporting metabolic homeostasis ...
Mehran Alipour +4 more
doaj +2 more sources
Maresin biosynthesis and identification of maresin 2, a new anti-inflammatory and pro-resolving mediator from human macrophages. [PDF]
PLoS ONE, 2014 Maresins are a new family of anti-inflammatory and pro-resolving lipid mediators biosynthesized from docosahexaenoic acid (DHA) by macrophages. Here we identified a novel pro-resolving product, 13R,14S-dihydroxy-docosahexaenoic acid (13R,14S-diHDHA ...
Bin Deng +6 more
doaj +4 more sources
Maresin 1 Mitigates High Glucose-Induced Mouse Glomerular Mesangial Cell Injury by Inhibiting Inflammation and Fibrosis [PDF]
Mediators of Inflammation, 2017 Background. Inflammation and fibrosis are the important pathophysiologic processes in diabetic nephropathy (DN). Maresin 1 is a potential anti-inflammatory lipid mediator, which has displayed powerful proresolving activities. Aim.
Shi Tang +7 more
doaj +2 more sources
Maresin 1 Inhibits TRPV1 in Temporomandibular Joint-Related Trigeminal Nociceptive Neurons and TMJ Inflammation-Induced Synaptic Plasticity in the Trigeminal Nucleus [PDF]
Mediators of Inflammation, 2015 In the trigeminal system, disruption of acute resolution processing may lead to uncontrolled inflammation and chronic pain associated with the temporomandibular joint (TMJ). Currently, there are no effective treatments for TMJ pain. Recently, it has been
Chul-Kyu Park
doaj +2 more sources
Maresin 1 induces resolution of hepatic fibrosis through RORα-dependent reprogramming of resident macrophages [PDF]
Frontiers in PharmacologyHepatic fibrosis is a progressive pathological condition characterized by chronic inflammation and excessive extracellular matrix deposition (ECM), which may progress to cirrhosis and liver failure. Although specialized pro-resolving lipid mediators have
Francisca Herrera Vielma +13 more
doaj +2 more sources
Maresin 1 promotes nerve regeneration and alleviates neuropathic pain after nerve injury [PDF]
Journal of Neuroinflammation, 2022 Background Peripheral nerve injury (PNI) is a public health concern that results in sensory and motor disorders as well as neuropathic pain and secondary lesions. Currently, effective treatments for PNI are still limited.
Jinhuan Wei +8 more
doaj +2 more sources
Maresin 1 Attenuates Lipopolysaccharide-Induced Acute Kidney Injury via Inhibiting NOX4/ROS/NF-κB Pathway [PDF]
Frontiers in Pharmacology, 2021 Sepsis-associated acute kidney injury (S-AKI) is a common complication in hospitalized and critically ill patients, which increases the risk of multiple comorbidities and is associated with extremely high mortality.
Jiameng Li +6 more
doaj +2 more sources
Decreased Plasma Maresin 1 Concentration Is Associated with Diabetic Foot Ulcer [PDF]
Mediators of Inflammation, 2020 Aims. To assess the maresin 1 (MaR1) contents in type 2 diabetic patients with or without diabetic foot ulcer and to analyze the association of MaR1 concentrations with several metabolism-related parameters. Methods.
Tian Miao +9 more
doaj +3 more sources
Circulating Maresin-1 and cartilage remodeling biomarkers in rheumatoid arthritis and osteoarthritis [PDF]
Scientific ReportsRheumatoid arthritis (RA) and osteoarthritis (OA) are prevalent chronic joint diseases characterized by persistent inflammation, progressive cartilage degeneration, and impaired tissue repair mechanisms.
Omer Esmez +5 more
doaj +2 more sources
Maresin 1 activates brown adipose tissue and promotes browning of white adipose tissue in mice [PDF]
Molecular Metabolism, 2023 Objective: Maresin 1 (MaR1) is a docosahexaenoic acid-derived proresolving lipid mediator with insulin-sensitizing and anti-steatosis properties. Here, we aim to unravel MaR1 actions on brown adipose tissue (BAT) activation and white adipose tissue (WAT)
Laura M. Laiglesia +19 more
doaj +2 more sources