Specialized pro-resolving mediator Maresin 1 attenuates pain in a mouse model of osteoarthritis [PDF]
Osteoarthritis and CartilageWe test whether the specialized pro-resolving molecule Maresin 1 (MaR1) attenuates nociceptive behaviors in mice with osteoarthritis-like pain.Osteoarthritis (OA)-like pain behavior was induced by intra-articular injection of monosodium iodoacetate (MIA) and treated with MaR1 (N=6) or vehicle (N=5) by intraperitoneal injection 8 weeks after injury ...
Yu-Ru V Shih +2 more
exaly +4 more sources
Maresin-1 Ameliorates Chronic Unpredictable Stress-Induced Depressive-like Behaviors Associated with Dynamic Modulation of Hippocampal Microglial Activity and TSPO PET Signals [PDF]
BiomedicinesBackground/Objectives: Maresin-1 (MaR1), a specialized pro-resolving mediator (SPM) derived from omega-3 fatty acids, has demonstrated potent anti-inflammatory and pro-resolving properties.
Anhai Zheng +7 more
doaj +2 more sources
Maresin 1 Exerts a Tissue-Specific Regulation of Adipo-Hepato-Myokines in Diet-Induced Obese Mice and Modulates Adipokine Expression in Cultured Human Adipocytes in Basal and Inflammatory Conditions [PDF]
Biomolecules, 2023 This study analyses the effects of Maresin 1 (MaR1), a docosahexaenoic acid (DHA)-derived specialized proresolving lipid mediator with anti-inflammatory and insulin-sensitizing actions, on the expression of adipokines, including adiponectin, leptin ...
Leyre Martínez-Fernández +6 more
doaj +2 more sources
Plasma and aqueous humor levels of Maresin-1 in patients with diabetic retinopathy [PDF]
Scientific ReportsThe aim of this study was to evaluate plasma and aqueous Maresin-1 (MaR1) levels in patients with diabetic retinopathy (DR) and to examine the ability of these levels to distinguish proliferative diabetic retinopathy.
Sabiha Güngör Kobat +8 more
doaj +2 more sources
Serum Resolvin D1 and Maresin 1 Levels During Migraine Attacks and the Interictal Period: A Paired Analysis in Emergency Department Patients [PDF]
BiomedicinesBackground/Objectives: Neurogenic inflammation plays a key role in migraine pathophysiology. This study aimed to evaluate serum Resolvin D1 (RvD1) and Maresin 1 (MaR1) levels during acute migraine attacks and in the interictal period in the same patients,
Miraç Koç +2 more
doaj +2 more sources
Maresin-1 suppresses imiquimod-induced skin inflammation by regulating IL-23 receptor expression [PDF]
Scientific Reports, 2018 The anti-inflammatory effect of omega 3 polyunsaturated fatty acids has been confirmed in various inflammatory disease models. Maresin-1 (MaR1) is a lipid mediator derived from the omega-3 fatty acid docosahexaenoic acid (DHA) that has displayed strong ...
Natsuko Saito-Sasaki +8 more
doaj +2 more sources
Effects of Maresin 1 (MaR1) on Colonic Inflammation and Gut Dysbiosis in Diet-Induced Obese Mice [PDF]
Microorganisms, 2020 The aim of this study was to characterize the effects of Maresin 1 (MaR1), a DHA-derived pro-resolving lipid mediator, on obesity-related colonic inflammation and gut dysbiosis in diet-induced obese (DIO) mice.
Irene C. León +5 more
doaj +6 more sources
Resolving Lipid Mediators Maresin 1 and Resolvin D2 Prevent Atheroprogression in Mice [PDF]
Circulation Research, 2016 Rationale: Atheroprogression is a consequence of nonresolved inflammation, and currently a comprehensive overview of the mechanisms preventing resolution is missing. However, in acute inflammation, resolution is known to be orchestrated by a switch from inflammatory to resolving lipid mediators ...
Viola, Joana R. +13 more
openaire +6 more sources
Maresin-1 alleviates sepsis-induced acute kidney injury by inhibiting ferroptosis via the Nrf2/HO-1/Gpx4 signaling pathway [PDF]
Renal FailurePurpose Sepsis-induced acute kidney injury (S-AKI) is a severe complication of sepsis. This study aimed to explore the protective effects of Maresin-1 (MaR-1) on S-AKI and elucidate its potential molecular mechanisms, focusing on ferroptosis and the Nrf2/
Lili Tang +5 more
doaj +2 more sources
Maresin 1 mitigates renal ischemia/reperfusion injury in mice via inhibition of the TLR4/MAPK/ NF-κB pathways and activation of the Nrf2 pathway [PDF]
Drug Design, Development and Therapy, 2019 Yun Qiu, Yichen Wu, Hongmei Zhao, Hong Sun, Sumin Gao Department of Emergency Medicine, The Affiliated Huaian No 1 People’s Hospital of Nanjing Medical University, Huai’an, Jiangsu Province, China Background: Inflammation and oxidative ...
Qiu Y, Wu Y, Zhao H, Sun H, Gao S
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