Results 131 to 140 of about 1,949 (158)

Maresin-1 resolution with RORα and LGR6

Progress in Lipid Research, 2020
Maresin-1, a pro-resolving lipid mediator, is drawing a great deal of attention in receptor pharmacology, largely because two distinct types of receptor molecules have been reported as the targets of maresin-1. One is retinoic acid-related orphan receptor α (RORα) and the other is leucine-rich repeat domain-containing G protein-coupled receptor 6 (LGR6)
Dong-Soon Im
exaly   +3 more sources

Stereoselective synthesis of maresin 1

Tetrahedron Letters, 2015
Abstract Maresin 1 is a potent anti-inflammatory and pro-resolving lipid mediator derived from docosahexaenoic acid. The total synthesis of maresin 1 is achieved in 10 steps and in 7% overall yield. The Evans–Nagao aldol reaction between (2E,4E)-5-bromopenta-2,4-dienal and different chiral auxiliaries is investigated.
Jørn Eivind Tungen, Marius Aursnes, Trond Vidar Hansen   +2 more
exaly   +2 more sources

Synthesis of maresin 1 and (7S)-isomer

Tetrahedron Letters, 2014
Maresin 1 (with the 7R carbon) and (7S)-maresin 1 were synthesized stereoselectively. The conjugated triene system was constructed by Pd-catalyzed coupling of the trans cis-dienylborane (the C10–C22 part) with the trans vinyl iodide corresponding to the C1–C9 part.
Narihito Ogawa, Toshifumi Tojo, Yuichi Kobayashi   +2 more
exaly   +2 more sources

Association of Low Serum Maresin-1 Levels with Hepatocellular Carcinoma in Cirrhotic Liver [PDF]

Clinical Laboratory
Maresin-1 (MaR1) is a macrophage-derived antiinflammatory lipid mediator that negatively regulates oxidative and proinflammatory cytokines and also restores integrity in various tissues after inflammation. Non-resolving inflammation is known to have an important role in the pathogenesis of hepatocellular carcinoma (HCC).
Ergül, Bilal, Gül, Özlem, Kisa, Üçler, Erdal, Harun, Tekin, Ercan, Oğuz, Dilek   +5 more
openaire   +4 more sources

Relationship between pancreatic cancer and Maresin 1

Journal of Current Hematology & Oncology Research, 2023
Aims: Pancreatic cancer is the 4th most common cause of death from cancer. In addition, pancreatic cancer is the most common primary malignant tumor of the pancreas. There are many risk factors for pancreatic cancer, including age, certain genetic syndromes, smoking, diabetes, alcohol abuse and obesity.
Hakan Varol, Özlem Gül, Bilal Ergül, Üçler Kısa, Ercan Tekin, Dilek Oğuz   +5 more
openaire   +1 more source

Maresin-1 induces cardiomyocyte hypertrophy through IGF-1 paracrine pathway

American Journal of Physiology-Cell Physiology, 2021
The resolution of inflammation is closely linked with tissue repair. Recent studies have revealed that macrophages suppress inflammatory reactions by producing lipid mediators, called specialized proresolving mediators (SPMs); however, the biological significance of SPMs in tissue repair remains to be fully elucidated in the heart.
Tri Wahyuni, Arisa Kobayashi, Shota Tanaka, Yoshiaki Miyake, Ayaha Yamamoto, Anton Bahtiar, Shota Mori, Yusuke Kametani, Masashi Tomimatsu, Kotaro Matsumoto, Makiko Maeda, Masanori Obana, Yasushi Fujio   +12 more
openaire   +2 more sources

Serum Maresin 1 levels in idiopathic acute anterior uveitis patients

Journal Français d'Ophtalmologie, 2022
The purpose of the present study is to assess the levels of Maresin 1 (MaR1) in patients with idiopathic acute anterior uveitis (IAAU) and to compare the MaR1 results with healthy controls.This study includes 24 patients with idiopathic AAU and 24 healty controls (C). The serum MaR1 levels were analyzed using enzyme-linked immunosorbent assays (ELISA).
F.C. Gül, S.G. Kobat, K. Kasar, S. Aydin, R.F. Akkoç   +4 more
openaire   +2 more sources

Identification of Metabolites of Maresin 1 in Human Neutrophils

The FASEB Journal, 2017
The resolution of inflammation, once considered to be rather passive, is now understood to be a complex, regulated process. One of the components in this process is the action of pro‐resolving lipid mediators, including lipoxins, resolvins, protectins and maresins.
Miguel A Gijón, Ann‐Charlotte Almstrand, Chris A Johnson, Robert C Murphy, Simona Zarini   +4 more
openaire   +1 more source

Maresin 1 Maintains the Permeability of Lung Epithelial Cells In Vitro and In Vivo

Inflammation, 2016
Previous reports showed that Maresin 1 (MaR1) possessed organ protection effects and could attenuate acute lung injury. Here, we aim to figure out whether MaR1 can maintain the permeability of lung epithelial cells by regulating the expression of tight junction protein during lung injury.
Lin, Chen, Hong, Liu, Yaxin, Wang, Haifa, Xia, Jie, Gong, Bo, Li, Shanglong, Yao, You, Shang   +7 more
openaire   +2 more sources

Diyabetik Nefropati ile Maresin-1 Düzeyleri Arasındaki İlişkinin Araştırılması

Amaç: Amacımız diyabetik nefropatide (DNP) maresin-1 (MaR1) düzeyini incelemek. Kontrolgrubu ve diyabetes mellitus (DM) tanısı olup DNP olmayan grup ile DNP olan grup arasındaMaR1 düzeyi açısından farklılık olup olmadığını tespit etmektir.Yöntem: Çalışmadaki hastalar üç gruba ayrıldı.
Altunok, Murat, Ertan, Hakan, Sevinç, Can, Tosun Taşar, Pınar, Uyanık, Abdullah, Çankaya, Erdem, Halıcı, Zekai   +6 more
openaire   +2 more sources