Inhibition of soluble epoxide hydrolase modulates inflammation and autophagy in obese adipose tissue and liver. Role for omega-3 epoxides [PDF]
, 2018 Soluble epoxide hydrolase (sEH) is an emerging therapeutic target in a number of diseases that have inflammation as a common underlying cause. sEH limits tissue levels of cytochrome P450 (CYP) epoxides derived from omega-6 and omega-3 polyunsaturated ...
Alcaraz-Quiles, José +9 more
core +1 more source
Macrophage proresolving mediator maresin 1 stimulates tissue regeneration and controls pain
The FASEB Journal, 2012 Self‐resolving inflammatory exudates and lipid mediator metabolomics recently uncovered a new family of potent anti‐inflammatory and proresolving mediators biosynthesized by macrophages (MΦs), denoted maresins. Here we determined that maresin 1 (MaR1) produced by human MΦs from endogenous docosahexaenoic acid (DHA) matched ...
Charles N, Serhan +8 more
openaire +3 more sources
Role of diets rich in omega-3 and omega-6 in the development of cancer
Boletín Médico del Hospital Infantil de México, 2016 Over the past decade, some studies have addressed the therapeutic effects of omega-3 polyunsaturated fatty acids (ω-3 PUFAs) and the opposite effects of omega-6 (ω-6) PUFAs on several diseases, including cardiovascular disorders, diabetes ...
Sara Huerta-Yépez +2 more
doaj +1 more source
Potential role of the lipoxygenase derived lipid mediators in atherosclerosis: leukotrienes, lipoxins and resolvins [PDF]
, 2017 Atherogenesis is an inflammatory process with leukocytes infiltrating the arterial intima. The lipoxygenase pathways play a role in leukocyte recruitment through the generation of two classes of arachidonic acid lipid mediators, the leukotrienes and the ...
Hersberger, Martin
core
Ketogenic diets attenuate cyclooxygenase and lipoxygenase gene expression in multiple sclerosis [PDF]
, 2018 Background: Adapted ketogenic diet (AKD) and caloric restriction (CR) have been suggested as alternative therapeutic strategies for inflammatory, hyperproliferative and neurodegenerative diseases.
Bock, Markus +2 more
core +2 more sources
Maresin‐1 ameliorates hypertensive vascular remodeling through its receptor LGR6
MedCommAbstractHypertensive vascular remodeling is defined as the changes in vascular function and structure induced by persistent hypertension. Maresin‐1 (MaR1), one of metabolites from Omega‐3 fatty acids, has been reported to promote inflammation resolution in several inflammatory diseases.
Zheng Yin +12 more
openaire +3 more sources
MoleculesInflammatory lung diseases (ILDs) represent a global public health crisis characterized by escalating prevalence, significant morbidity, and substantial mortality.
Ángel Ortega +11 more
doaj +1 more source
Emerging Concepts in the Resolution of Periodontal Inflammation: A Role for Resolvin E1
Frontiers in Immunology, 2017 Inflammatory response is a protective biological process intended to eliminate the harmful effect of the insulting influx. Resolution of inflammation constitutes an active sequence of overlapping events mediated by specialized proresolving mediators ...
Maria G. Balta +3 more
doaj +1 more source
Untersuchungen zum Einfluss eines erhöhten Omega-3 Fettsäure Gehaltes auf das Lipidmediatorenprofil und zum anti-inflammatorischen Potential der murinen 15-Lipoxygenase, 17-Hydroxydocosapentaensäure und 10,17-Dihydroxydocosapentaensäure [PDF]
, 2019 Long-chain polyunsaturated omega-3 (n-3 PUFA) and omega-6 fatty acids are precursors of highly potent lipid mediators and metabolites, which are synthesized via cyclooxygenases, lipoxygenases (LOX), cytochrome P450 (CYP-450) or via autooxidation ...
Chiu, Cheng-Ying
core +1 more source
Role of omega-3 fatty acids and their metabolites in asthma and allergic diseases
Allergology International, 2015 Omega-3 fatty acids, docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), are found naturally in fish oil and are commonly thought to be anti-inflammatory nutrients, with protective effects in inflammatory diseases including asthma and allergies ...
Jun Miyata, Makoto Arita
doaj +1 more source