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Serum Maresin 1 levels in idiopathic acute anterior uveitis patients
Journal Français d'Ophtalmologie, 2022The purpose of the present study is to assess the levels of Maresin 1 (MaR1) in patients with idiopathic acute anterior uveitis (IAAU) and to compare the MaR1 results with healthy controls.This study includes 24 patients with idiopathic AAU and 24 healty controls (C). The serum MaR1 levels were analyzed using enzyme-linked immunosorbent assays (ELISA).
F.C. Gül +4 more
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Stereoselective synthesis of maresin 1
Tetrahedron Letters, 2015Abstract Maresin 1 is a potent anti-inflammatory and pro-resolving lipid mediator derived from docosahexaenoic acid. The total synthesis of maresin 1 is achieved in 10 steps and in 7% overall yield. The Evans–Nagao aldol reaction between (2E,4E)-5-bromopenta-2,4-dienal and different chiral auxiliaries is investigated.
Jørn E. Tungen +2 more
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Maresin-1 resolution with RORα and LGR6
Progress in Lipid Research, 2020Maresin-1, a pro-resolving lipid mediator, is drawing a great deal of attention in receptor pharmacology, largely because two distinct types of receptor molecules have been reported as the targets of maresin-1. One is retinoic acid-related orphan receptor α (RORα) and the other is leucine-rich repeat domain-containing G protein-coupled receptor 6 (LGR6)
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Synthesis of maresin 1 and (7S)-isomer
Tetrahedron Letters, 2014Maresin 1 (with the 7R carbon) and (7S)-maresin 1 were synthesized stereoselectively. The conjugated triene system was constructed by Pd-catalyzed coupling of the trans cis-dienylborane (the C10–C22 part) with the trans vinyl iodide corresponding to the C1–C9 part.
Narihito Ogawa +2 more
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Maresin 1 intervention reverses experimental pulmonary arterial hypertension in mice
British Journal of Pharmacology, 2022Background and PurposePulmonary arterial hypertension (PAH) is a pulmonary vasculature obstructive disease that leads to right heart failure and death. Maresin 1 is an endogenous lipid mediator known to promote inflammation resolution. However, the effect of Maresin 1 on PAH remains unclear.Experimental ApproachThe serum Maresin 1 concentration was ...
Hui Li +18 more
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Maresin-1 induces cardiomyocyte hypertrophy through IGF-1 paracrine pathway
American Journal of Physiology-Cell Physiology, 2021The resolution of inflammation is closely linked with tissue repair. Recent studies have revealed that macrophages suppress inflammatory reactions by producing lipid mediators, called specialized proresolving mediators (SPMs); however, the biological significance of SPMs in tissue repair remains to be fully elucidated in the heart.
Tri Wahyuni +12 more
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Total Synthesis and Bioactivities of Two Proposed Structures of Maresin
Chemistry – An Asian Journal, 2010AbstractMaresin is a potent anti‐inflammatory lipid mediator derived from docosahexaenoic acid (DHA). A highly convergent total synthesis of two proposed structures of C7‐epimeric maresins from the four known fragments was achieved in 17 steps. The three key coupling reactions were the BF3‐mediated alkyne attack on the epoxide, chiral titanium complex ...
Kenji, Sasaki +4 more
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Identification of Metabolites of Maresin 1 in Human Neutrophils
The FASEB Journal, 2017The resolution of inflammation, once considered to be rather passive, is now understood to be a complex, regulated process. One of the components in this process is the action of pro‐resolving lipid mediators, including lipoxins, resolvins, protectins and maresins.
Miguel A Gijón +4 more
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