Results 161 to 170 of about 3,920 (194)

Abstract 1329: Maresins prevent breast cancer dormancy escape via resolution of inflammation

Cancer Research, 2022
Cytotoxic cancer therapies reduce tumor burden by killing tumor cells. However, the resulting apoptotic and necrotic cell bodies (tumor cell “debris”) may stimulate tumor initiation and progression by disrupting the resolution of inflammation.
Franciele Kipper, Jianjun Deng, Eva Rothenberger, Abigail G. Kelly, M. Duncan, Sui Huang, C. Serhan, D. Panigrahy   +7 more
semanticscholar   +1 more source

Immuno-Resolving Ability of Resolvins, Protectins, and Maresins Derived from Omega-3 Fatty Acids in Metabolic Syndrome.

Molecular Nutrition & Food Research, 2019
Omega-3 fatty acid consumption has been suggested to be beneficial for the prevention of type 2 diabetes mellitus (T2DM). Its effects have been attributed to anti-inflammatory activity, with the inhibition of arachidonic acid metabolism playing a central
Y. Kwon
semanticscholar   +1 more source

Stereoselective synthesis of maresin 1

Tetrahedron Letters, 2015
Abstract Maresin 1 is a potent anti-inflammatory and pro-resolving lipid mediator derived from docosahexaenoic acid. The total synthesis of maresin 1 is achieved in 10 steps and in 7% overall yield. The Evans–Nagao aldol reaction between (2E,4E)-5-bromopenta-2,4-dienal and different chiral auxiliaries is investigated.
Jørn E. Tungen, Marius Aursnes, Trond Vidar Hansen   +2 more
openaire   +1 more source

Relationship between pancreatic cancer and Maresin 1

Journal of Current Hematology & Oncology Research, 2023
Aims: Pancreatic cancer is the 4th most common cause of death from cancer. In addition, pancreatic cancer is the most common primary malignant tumor of the pancreas. There are many risk factors for pancreatic cancer, including age, certain genetic syndromes, smoking, diabetes, alcohol abuse and obesity.
Hakan Varol, Özlem Gül, Bilal Ergül, Üçler Kısa, Ercan Tekin, Dilek Oğuz   +5 more
openaire   +1 more source

Maresin-1 resolution with RORα and LGR6

Progress in Lipid Research, 2020
Maresin-1, a pro-resolving lipid mediator, is drawing a great deal of attention in receptor pharmacology, largely because two distinct types of receptor molecules have been reported as the targets of maresin-1. One is retinoic acid-related orphan receptor α (RORα) and the other is leucine-rich repeat domain-containing G protein-coupled receptor 6 (LGR6)
openaire   +2 more sources

Synthesis of maresin 1 and (7S)-isomer

Tetrahedron Letters, 2014
Maresin 1 (with the 7R carbon) and (7S)-maresin 1 were synthesized stereoselectively. The conjugated triene system was constructed by Pd-catalyzed coupling of the trans cis-dienylborane (the C10–C22 part) with the trans vinyl iodide corresponding to the C1–C9 part.
Narihito Ogawa, Toshifumi Tojo, Yuichi Kobayashi   +2 more
openaire   +1 more source

Total Synthesis and Bioactivities of Two Proposed Structures of Maresin

Chemistry – An Asian Journal, 2010
AbstractMaresin is a potent anti‐inflammatory lipid mediator derived from docosahexaenoic acid (DHA). A highly convergent total synthesis of two proposed structures of C7‐epimeric maresins from the four known fragments was achieved in 17 steps. The three key coupling reactions were the BF3‐mediated alkyne attack on the epoxide, chiral titanium complex ...
Kenji, Sasaki, Daisuke, Urabe, Hiroyuki, Arai, Makoto, Arita, Masayuki, Inoue   +4 more
openaire   +2 more sources

Lipoxins, resolvins, protectins, maresins and nitrolipids, and their clinical implications with specific reference to cancer: part I

Clinical Lipidology, 2013
U. Das
exaly   +3 more sources

Serum Maresin 1 levels in idiopathic acute anterior uveitis patients

Journal Français d'Ophtalmologie, 2022
The purpose of the present study is to assess the levels of Maresin 1 (MaR1) in patients with idiopathic acute anterior uveitis (IAAU) and to compare the MaR1 results with healthy controls.This study includes 24 patients with idiopathic AAU and 24 healty controls (C). The serum MaR1 levels were analyzed using enzyme-linked immunosorbent assays (ELISA).
F.C. Gül, S.G. Kobat, K. Kasar, S. Aydin, R.F. Akkoç   +4 more
openaire   +2 more sources

Resolution of inflammation: An organizing principle in biology and medicine.

Pharmacology and Therapeutics, 2021
The resolution of inflammation has emerged as a critical endogenous process that protects host tissues from prolonged or excessive inflammation that can become chronic. Failure of the resolution of inflammation is a key pathological mechanism that drives
D. Panigrahy, Molly M Gilligan, C. Serhan, K. Kashfi   +3 more
semanticscholar   +1 more source