Results 151 to 160 of about 3,018 (169)
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Total Synthesis and Bioactivities of Two Proposed Structures of Maresin
Chemistry – An Asian Journal, 2010AbstractMaresin is a potent anti‐inflammatory lipid mediator derived from docosahexaenoic acid (DHA). A highly convergent total synthesis of two proposed structures of C7‐epimeric maresins from the four known fragments was achieved in 17 steps. The three key coupling reactions were the BF3‐mediated alkyne attack on the epoxide, chiral titanium complex ...
Kenji, Sasaki +4 more
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Serum Maresin 1 levels in idiopathic acute anterior uveitis patients
Journal Français d'Ophtalmologie, 2022The purpose of the present study is to assess the levels of Maresin 1 (MaR1) in patients with idiopathic acute anterior uveitis (IAAU) and to compare the MaR1 results with healthy controls.This study includes 24 patients with idiopathic AAU and 24 healty controls (C). The serum MaR1 levels were analyzed using enzyme-linked immunosorbent assays (ELISA).
F.C. Gül +4 more
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Periodontal Stem Cells Synthesize Maresin Conjugate in Tissue Regeneration 3
Journal of Dental Research, 2022Periodontal disease is a significant public health problem worldwide. Excess unresolved chronic inflammation destroys the periodontal tissues that surround and support the teeth, and efforts to control inflammation by removal of bacterial deposits on the teeth have limited long-term impact.
A. Rakian +4 more
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Maresin 1 intervention reverses experimental pulmonary arterial hypertension in mice
British Journal of Pharmacology, 2022Background and PurposePulmonary arterial hypertension (PAH) is a pulmonary vasculature obstructive disease that leads to right heart failure and death. Maresin 1 is an endogenous lipid mediator known to promote inflammation resolution. However, the effect of Maresin 1 on PAH remains unclear.Experimental ApproachThe serum Maresin 1 concentration was ...
Hui Li +18 more
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Identification of Metabolites of Maresin 1 in Human Neutrophils
The FASEB Journal, 2017The resolution of inflammation, once considered to be rather passive, is now understood to be a complex, regulated process. One of the components in this process is the action of pro‐resolving lipid mediators, including lipoxins, resolvins, protectins and maresins.
Miguel A Gijón +4 more
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Maresin 1 Maintains the Permeability of Lung Epithelial Cells In Vitro and In Vivo
Inflammation, 2016Previous reports showed that Maresin 1 (MaR1) possessed organ protection effects and could attenuate acute lung injury. Here, we aim to figure out whether MaR1 can maintain the permeability of lung epithelial cells by regulating the expression of tight junction protein during lung injury.
Lin, Chen +7 more
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Are decreased serum Maresin 1 levels predictive of cholangiocarcinoma?
Journal of Current Hematology & Oncology ResearchAims: Cholangiocarcinoma (CC) is a rare form of adenocarcinoma originating from the epithelial cells of the biliary tract. Chronic inflammation is known to be a risk factor for this tumor. The present study aimed to investigate whether serum levels of Maresin 1 (MaR1) (a macrophage-derived anti-inflammatory lipid mediator) were associated with the ...
Salih Karatlı +4 more
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Upregulation of the maresin pathway and PGE2 metabolism in the failing human left ventricle
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of LipidsChronic inflammation is involved in the pathogenesis of heart failure (HF), with cardiac remodeling and fibrosis resulting from sustained myofibroblasts activation. This is due to an imbalance between pro-inflammatory and pro-resolving mediators including specialized pro-resolving lipid mediators (SPM).
Amel, Bouhadoun +17 more
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