Results 141 to 150 of about 3,018 (169)
The Potential of Bioactive Plant Phytochemicals, Pro-Resolving Anti-Inflammatory Lipids, and Statins in the Inhibition of Intervertebral Disc Degeneration, Low Back Pain Resolution, Disc Functional Repair, and Promotion of Intervertebral Disc Regeneration. [PDF]
CellsMelrose J.
europepmc +1 more source
Major Structure–Activity Relationships of Resolvins, Protectins, Maresins and Their Analogues
Future Medicinal Chemistry, 2022 Resolvins, protectins and maresins are a series of polyunsaturated fatty acid-derived molecules which play important roles in the resolution of inflammation. They are termed specialized proresolving mediators and facilitate a return to homeostasis following an inflammatory response.
Timothy P O'Sullivan
exaly +4 more sources
Maresins: The Mainstay in Periodontal Resolution [PDF]
Cureus, 2022 Not much was known about the resolution of inflammation until the recent past when significant breakthroughs led to the unveiling of the exact mechanism of this. It is now known that the resolution of inflammation involves specific mediators of resolution such as lipoxins, protectins, resolvins, and maresins, making it an active process.
Gireddy, Hima Bindu +5 more
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DHA- and EPA-derived resolvins, protectins, and maresins in airway inflammation [PDF]
European Journal of Pharmacology, 2016 Essential fatty acids can serve as important regulators of inflammation. A new window into mechanisms for the resolution of inflammation was opened with the identification and structural elucidation of mediators derived from these fatty acids with pro-resolving capacity.
Melody G Duvall, Bruce D Levy
exaly +3 more sources
The Role of Maresins in Inflammatory Pain: Function of Macrophages in Wound Regeneration [PDF]
International Journal of Molecular Sciences, 2019 Although acute inflammatory responses are host-protective and generally self-limited, unresolved and delayed resolution of acute inflammation can lead to further tissue damage and chronic inflammation. The mechanism of pain induction under inflammatory conditions has been studied extensively; however, the mechanism of pain resolution is not fully ...
Sung-Min Hwang +2 more
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Relationship between pancreatic cancer and Maresin 1
Journal of Current Hematology & Oncology Research, 2023Aims: Pancreatic cancer is the 4th most common cause of death from cancer. In addition, pancreatic cancer is the most common primary malignant tumor of the pancreas. There are many risk factors for pancreatic cancer, including age, certain genetic syndromes, smoking, diabetes, alcohol abuse and obesity.
Hakan Varol +5 more
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Stereoselective synthesis of maresin 1
Tetrahedron Letters, 2015Abstract Maresin 1 is a potent anti-inflammatory and pro-resolving lipid mediator derived from docosahexaenoic acid. The total synthesis of maresin 1 is achieved in 10 steps and in 7% overall yield. The Evans–Nagao aldol reaction between (2E,4E)-5-bromopenta-2,4-dienal and different chiral auxiliaries is investigated.
Jørn E. Tungen +2 more
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Synthesis of maresin 1 and (7S)-isomer
Tetrahedron Letters, 2014Maresin 1 (with the 7R carbon) and (7S)-maresin 1 were synthesized stereoselectively. The conjugated triene system was constructed by Pd-catalyzed coupling of the trans cis-dienylborane (the C10–C22 part) with the trans vinyl iodide corresponding to the C1–C9 part.
Narihito Ogawa +2 more
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Maresin-1 resolution with RORα and LGR6
Progress in Lipid Research, 2020Maresin-1, a pro-resolving lipid mediator, is drawing a great deal of attention in receptor pharmacology, largely because two distinct types of receptor molecules have been reported as the targets of maresin-1. One is retinoic acid-related orphan receptor α (RORα) and the other is leucine-rich repeat domain-containing G protein-coupled receptor 6 (LGR6)
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