Reversion of Val(Ganciclovir)-Resistance-Associated Mutations in Two SOT Patients with Mismatched Serostatus for CMV (D+/R-) [PDF]
VirusesThe emergence of drug-resistant cytomegalovirus (CMV) complicates viral response to therapy. We present two cases of solid organ transplant (SOT) recipients, highlighting the reversion of UL97 mutations associated with val(ganciclovir) resistance ...
Elena Seminari +9 more
doaj +2 more sources
Refractory CMV Enteritis in Small Bowel Transplantation: A Case Highlighting the Challenges of Balancing Immunosuppression and Novel Antiviral Therapies [PDF]
VirusesBackground: Cytomegalovirus (CMV) remains a formidable complication in small bowel transplantation (SBT) due to the graft’s high immunogenicity and profound immunosuppression required, with refractory disease representing a particularly devastating ...
Abdulrahman A. Al-Saud +6 more
doaj +2 more sources
A novel strategy for the management of cytomegalovirus retinitis in immunocompromised patients using new anti-cytomegalovirus drugs [PDF]
Frontiers in MedicineObjectivesThis study presents four cases of cytomegalovirus retinitis (CMVR) managed using a novel antiviral strategy, aiming to preliminarily assess its efficacy and safety profile.MethodsA retrospective chart review was conducted on four patients ...
Yuou Yao +7 more
doaj +2 more sources
Optimizing CMV therapy: Population pharmacokinetics and Monte Carlo simulations for letermovir and maribavir dosage. [PDF]
PLoS ONEPurposeThis study seeks to reassess and enhance the dosing strategies of letermovir and maribavir for treating cytomegalovirus (CMV) infection, aiming to propose adjustments that could improve therapeutic effectiveness.MethodsPre-existing population ...
Yeleen Fromage +5 more
doaj +2 more sources
Maribavir: Mechanism of action, clinical, and translational science
Clinical and Translational ScienceMaribavir is an oral benzimidazole riboside for treatment of post‐transplant cytomegalovirus (CMV) infection/disease that is refractory to prior antiviral treatment (with or without resistance).
Kefeng Sun +3 more
doaj +3 more sources
Intravitreal foscarnet is an effective adjunct after systemic therapy failure in pediatric antiviral-resistant cytomegalovirus retinitis [PDF]
Journal of International Medical ResearchThis report describes the case of a school-aged male child with T-cell acute lymphoblastic leukemia who developed cytomegalovirus retinitis despite systemic antiviral therapy.
Iden Amiri +3 more
doaj +2 more sources
Interplay of Belatacept Immunosuppression and Maribavir Antiviral Activity in Recurrent CMV Viremia: Clinical Implications and Literature Review [PDF]
VirusesBelatacept is a recombinant fusion protein used in renal transplant recipients, particularly when side effects from standard immunosuppressants occur. It offers a superior renal safety profile and is associated with better long-term renal graft outcomes.
Imran Gani, Ahmad Mirza, Usman Baig
doaj +2 more sources
Synthesis of New Imidazopyridine Nucleoside Derivatives Designed as Maribavir Analogues [PDF]
Molecules, 2020 The strong inhibition of Human Cytomegalovirus (HCMV) replication by benzimidazole nucleosides, like Triciribine and Maribavir, has prompted us to expand the structure–activity relationships of the benzimidazole series, using as a central core the ...
Georgios Papadakis +6 more
doaj +4 more sources
Maribavir for Preemptive Treatment of Cytomegalovirus Reactivation
New England Journal of Medicine, 2019 Maribavir is a benzimidazole riboside with activity against cytomegalovirus (CMV). The safety and efficacy of maribavir for preemptive treatment of CMV infection in transplant recipients is not known.In a phase 2, open-label, maribavir dose-blinded trial, recipients of hematopoietic-cell or solid-organ transplants (≥18 years of age, with CMV ...
Johan Maertens +2 more
exaly +3 more sources
In Silico Analysis of Mechanisms of Maribavir-Induced Inhibition and Drug Resistance Mutations in pUL97 Kinase Structural Prediction with AlphaFold2 [PDF]
VirusesInfections with cytomegalovirus (CMV) can result in increased morbidity and mortality in immunocompromised patients. The pUL97 kinase is a critical enzyme in the regulation of CMV replication.
Jocelyne Piret, Guy Boivin
doaj +2 more sources