Refractory CMV Enteritis in Small Bowel Transplantation: A Case Highlighting the Challenges of Balancing Immunosuppression and Novel Antiviral Therapies [PDF]
VirusesBackground: Cytomegalovirus (CMV) remains a formidable complication in small bowel transplantation (SBT) due to the graft’s high immunogenicity and profound immunosuppression required, with refractory disease representing a particularly devastating ...
Abdulrahman A. Al-Saud +6 more
doaj +2 more sources
Treatment for First Cytomegalovirus Infection Post–Hematopoietic Cell Transplant in the AURORA Trial: A Multicenter, Double-Blind, Randomized, Phase 3 Trial Comparing Maribavir With Valganciclovir [PDF]
Clinical Infectious DiseasesBackground Neutropenia may limit the use of valganciclovir treatment for cytomegalovirus (CMV) infection following hematopoietic cell transplant (HCT).
Johan A Maertens +2 more
exaly +3 more sources
A novel strategy for the management of cytomegalovirus retinitis in immunocompromised patients using new anti-cytomegalovirus drugs [PDF]
Frontiers in MedicineObjectivesThis study presents four cases of cytomegalovirus retinitis (CMVR) managed using a novel antiviral strategy, aiming to preliminarily assess its efficacy and safety profile.MethodsA retrospective chart review was conducted on four patients ...
Yuou Yao +7 more
doaj +2 more sources
Optimizing CMV therapy: Population pharmacokinetics and Monte Carlo simulations for letermovir and maribavir dosage. [PDF]
PLoS ONEPurposeThis study seeks to reassess and enhance the dosing strategies of letermovir and maribavir for treating cytomegalovirus (CMV) infection, aiming to propose adjustments that could improve therapeutic effectiveness.MethodsPre-existing population ...
Yeleen Fromage +5 more
doaj +2 more sources
Human cytomegalovirus UL27 is not required for viral replication in human tissue implanted in SCID mice [PDF]
Virology Journal, 2006 Inhibition of the human cytomegalovirus UL97 kinase by maribavir is thought to be responsible for the antiviral activity of this compound. Some mutations that confer resistance to maribavir map to UL97, however additional mutations that also confer ...
Chou Sunwen +6 more
doaj +3 more sources
POSSIBILITIES OF PREVENTION AND TREATMENT OF HUMAN CYTOMEGALOVIRUS INFECTIONS INCLUDING NEW DRUGS AND COMPOUNDS WITH POTENTIAL APPLICATION [PDF]
Antimicrobial Agents and Chemotherapy, 2019 ABSTRACT Human cytomegalovirus (HCMV) is a widespread pathogen that can cause severe disease in immunologically immature and immunocompromised individuals. Cyclopropavir (CPV) is a guanine nucleoside analog active against human and murine cytomegaloviruses in cell culture and efficacious in mice by oral administration.
Majewska, Anna +4 more
core +5 more sources
Interplay of Belatacept Immunosuppression and Maribavir Antiviral Activity in Recurrent CMV Viremia: Clinical Implications and Literature Review [PDF]
VirusesBelatacept is a recombinant fusion protein used in renal transplant recipients, particularly when side effects from standard immunosuppressants occur. It offers a superior renal safety profile and is associated with better long-term renal graft outcomes.
Imran Gani, Ahmad Mirza, Usman Baig
doaj +2 more sources
Maribavir for Cytomegalovirus Infection in High‐Risk Kidney Transplant Recipients: A Case Series
IJU Case ReportsBackground Cytomegalovirus (CMV) infection remains a common complication after kidney transplantation, particularly among high‐risk donor‐seropositive/recipient‐seronegative (D+/R−) recipients.
Daiji Takamoto +6 more
doaj +2 more sources
Intravitreal foscarnet is an effective adjunct after systemic therapy failure in pediatric antiviral-resistant cytomegalovirus retinitis [PDF]
Journal of International Medical ResearchThis report describes the case of a school-aged male child with T-cell acute lymphoblastic leukemia who developed cytomegalovirus retinitis despite systemic antiviral therapy.
Iden Amiri +3 more
doaj +2 more sources
Maribavir: Mechanism of action, clinical, and translational science
Clinical and Translational ScienceMaribavir is an oral benzimidazole riboside for treatment of post‐transplant cytomegalovirus (CMV) infection/disease that is refractory to prior antiviral treatment (with or without resistance).
Kefeng Sun +3 more
doaj +3 more sources