Results 61 to 70 of about 606 (121)

Marinobufagenin Stimulates Fibroblast Collagen Production and Causes Fibrosis in Experimental Uremic Cardiomyopathy

, 2006
We have observed recently that experimental renal failure in the rat is accompanied by increases in circulating concentrations of the cardiotonic steroid, marinobufagenin (MBG), and substantial cardiac fibrosis.
Vetteth, Sandeep, Yashaswi, Belvadi, Smaili, Sleiman, Xie, Zijian, Shapiro, Joseph I., M.D., Kim, Eric G.R., Bagrov, Alexei Y., Fedorova, Larisa, Fedorova, Olga V., Kashkin, Vladimir A., Malhotra, Deepak, Wu, Liang, Elkareh, Jihad, Shidyak, Amjad, Liu, Jiang, Periyasamy, Sankaridrug M., Kahaleh, M. Bashar, Kennedy, David J., Hariri, Imad M.   +18 more
core  

Central Role for the Cardiotonic Steroid Marinobufagenin in the Pathogenesis of Experimental Uremic Cardiomyopathy

, 2005
Patients with chronic renal failure develop a “uremic” cardiomyopathy characterized by diastolic dysfunction, cardiac hypertrophy, and systemic oxidant stress.
Vetteth, Sandeep, Xie, Zijian, Shapiro, Joseph I., MD, Bagrov, Alexei Y., Fedorova, Larisa, Fedorova, Olga V., Kolodkin, Nikolai I., Kanj, Mohamed, Malhotra, Deepak, Khouri, Samer, Periyasamy, Sankaridrug M., Kahaleh, M. Bashar, Kennedy, David J., Lakatta, Edward G.   +13 more
core  

Chronic Kidney Disease: Underlying Molecular Mechanisms-A Special Issue Overview. [PDF]

Int J Mol Sci, 2023
Belo L, Carvalho M.
europepmc   +1 more source

Challenges and novel strategies for quantification of marinobufagenin within the framework of preeclampsia [PDF]

, 2013
Marinobufagenin (MBG), a bufadienolide cardiac inotrope, enjoys a growing interest in the early diagnosis of volume expansion-mediated hypertensive states such as preeclampsia (PE).
Demeyer, Marie, Blankert, Bertrand, Lenaerts, Charline, Gerbaux, Pascal   +3 more
core  

Elaboration of a quantification assay of marinobufagenin in human plasma: a novel approach based on response factor quantification by LC-MS/MS [PDF]

, 2016
Marinobufagenin (MBG) is a bufadienolide cardiac inotrope implicated in the early diagnosis of volume expansion-mediated hypertensive states such as preeclampsia (PE).
Delporte, Cédric, Van Antwerpen, P., Bond, Liz, Blankert, Bertrand, Tuytten, Robin, Lenaerts, Charline   +5 more
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Monoclonal antibody against marinobufagenin reverses cardiac fibrosis in rats with chronic renal failure

, 2012
Background Cardiotonic steroids (CTS) are implicated in pathophysiology of uremic cardiomyopathy. In the present study, we tested whether a monoclonal antibody (mAb) against the bufadienolide CTS, marinobufagenin (MBG), alleviates cardiac hypertrophy and
Shidyak, Amjad, Shapiro, Joseph I., M.D., Haller, Steven T., Kennedy, David J., Bagrov, Alexi Y., Bundy, George V., Fedorova, Olga V., Malhorta, Deepak   +7 more
core  

Chronic Administration of Marinobufagenin in Mice Causes Hyperlocomotion and Decrease in Anxiety by Altering Monoamine Turnover Unaccompanied by Motor Deficits or Oxidative Stress. [PDF]

Int J Mol Sci
Kazanskaya RB, Lobaskova AO, Iushina AD, Abaimov DA, Kulikova OI, Volnova AB, Tsytsarev V, Lopachev AV.   +7 more
europepmc   +1 more source

Endogenous Digitalis-like Factors as a Key Molecule in the Pathophysiology of Pregnancy-Induced Hypertension and a Potential Therapeutic Target in Preeclampsia. [PDF]

Int J Mol Sci, 2023
Socha MW, Chmielewski J, Pietrus M, Wartęga M.   +3 more
europepmc   +1 more source

Depth of the Steroid Core Location Determines the Mode of Na,K-ATPase Inhibition by Cardiotonic Steroids. [PDF]

Int J Mol Sci, 2021
Tverskoi AM, Poluektov YM, Klimanova EA, Mitkevich VA, Makarov AA, Orlov SN, Petrushanko IY, Lopina OD.   +7 more
europepmc   +1 more source

Mechanisms mediating effects of cardiotonic steroids in mammalian blood cells. [PDF]

Front Pharmacol
Poluektov YM, Lopina OD, Strelkova MA, Kuleshova ID, Makarov AA, Petrushanko IY.   +5 more
europepmc   +1 more source