Results 41 to 50 of about 606 (121)

Marinobufagenin concentrations and decline in estimated glomerular filtration rate.

, 2019
Scatterplot of plasma marinobufagenin (MBG) concentrations at baseline visit (in nmol/L) and difference in estimated glomerular filtration rate (GFR, in ml/min/1.73m2) at follow-up: Regression line (solid line) with 95% confidence interval (dotted lines)
Thomas K. Felder (6411017), Janne Cadamuro (5488640), Hannes Oberkofler (183917), Nicolas Verheyen (3924695), Valentin Borzan (6411026), Simon Auer (6411014), Christian Trummer (3611288), Marlene Pandis (6411023), Martin H. Keppel (6411008), Elisabeth Haschke-Becher (332443), Stefan Pilz (279331), Verena Schwetz (643535), Martin R. Grübler (5807357), Grzegorz Piecha (6411011), Cornelia Mrazek (6411020), Andreas Tomaschitz (3752992), Winfried März (106288)   +16 more
core   +1 more source

Effects of Na/K-ATPase and its ligands on bone marrow stromal cell differentiation

Stem Cell Research, 2014
Endogenous ligands of Na/K-ATPase have been demonstrated to increase in kidney dysfunction and heart failure. It is also reported that Na/K-ATPase signaling function effects stem cell differentiation.
Moustafa Sayed, Christopher A. Drummond, Kaleigh L. Evans, Steven T. Haller, Jiang Liu, Zijian Xie, Jiang Tian   +6 more
doaj   +1 more source

Endogenous Digitalis-like Factors: An Overview of the History

Frontiers in Endocrinology, 2015
The sodium pump is a ubiquitous cell surface enzyme, a Na, K ATPase, which maintains ion gradients between cells and the extracellular fluid (ECF). The extracellular domain of this enzyme contains a highly conserved binding site, a receptor for a plant ...
Vardaman eBuckalew
doaj   +1 more source

Analysis of marinobufagenin in plasma for preeclampsia risk assessment: a promising early predictive tool [PDF]

, 2014
peer reviewedMarinobufagenin (MBG) is a bufadienolide compound belonging to the cardiac glycoside class and is present in humans as well as in some plants and other animals.
Bond, Liz, Blankert, Bertrand, Tuytten, Robin, Lenaerts, Charline   +3 more
core   +1 more source

D3. Early prediction of preeclampsia risk assessment: analytical determination for marinobufagenin in pregnant women.

, 2016
Marinobufagenin (MBG), an endogenous bufadienolide cardiac inotrope, is responsible for vasoconstriction and natriuresis [1,2]. Growing interest by its implication in volume expansion mediated hypertensive states such as essential hypertension ...
Delporte, Cédric, Van Antwerpen, Pierre, Bond, Liz, Blankert, Bertrand, Tuytten, Robin, Lenaerts, C   +5 more
core   +1 more source

Plasma level of the endogenous sodium pump ligand marinobufagenin is related to the salt-sensitivity in men.

, 2015
Salt-induced elevation of the endogenous digitalis like sodium pump ligand marinobufagenin (MBG) in the Dahl salt-sensitive rats resulted in elevated blood pressure (BP).
Bagrov, Alexei Y, Fedorova, Olga V, Lakatta, Edward G, Melander, Olle   +3 more
core   +1 more source

Marinobufagenin is an upstream modulator of Gadd45a stress signaling in preeclampsia [PDF]

, 2010
Preeclampsia (PE) is a hypertensive disorder of pregnancy, in which marinobufagenin (MBG), a circulating cardiotonic steroid, is increased. The Gadd45a stress sensor protein is an upstream modulator of the pathophysiological changes observed in PE ...
DeMorrow, Sharon, Jules B. Puschett, Puschett, Jules B., Uddin, Mohammad N., Mohammad N. Uddin, Sharon DeMorrow, Enoch Agunanne, Darijana Horvat, Horvat, Darijana, Agunanne, Enoch   +9 more
core   +1 more source

5.4 A MONOCLONAL ANTIBODY TO AN ENDOGENOUS NA/K-ATPASE LIGAND, MARINOBUFAGENIN, REVERSES EXPRESSION OF PRO-FIBROTIC GENES AND REDUCES CARDIOVASCULAR FIBROSIS IN AGED RATS

Artery Research, 2013
Cardiovascular fibrosis is a hallmark of aging. We had previously demonstrated, that a steroidal endogenous Na/K-ATPase inhibitor, marinobufagenin (MBG), plays a central role in cardiac fibrosis occurring in the context of experimental uremic ...
O.V. Fedorova, V. Shilova, V. Zernetkina, Y. Zhang, E. Lehrmann, K.G. Becker, E.G. Lakatta, A.Y. Bagrov   +7 more
doaj   +1 more source

Preeclampsia: Cardiotonic Steroids, Fibrosis, Fli1 and Hint to Carcinogenesis

, 2021
Despite prophylaxis and attempts to select a therapy, the frequency of preeclampsia does not decrease and it still takes the leading position in the structure of maternal mortality and morbidity worldwide.
Alexander P. Trashkov, Natalia I. Agalakova, C. David Adair, Nikolai I. Kolodkin, Alexei Y. Bagrov   +4 more
core   +1 more source

The endogenous cardiotonic steroid Marinobufagenin and decline in estimated glomerular filtration rate at follow-up in patients with arterial hypertension.

PLoS ONE, 2019
BackgroundMarinobufagenin (MBG) is an endogenous cardiotonic steroid (CTS) that inhibits the Na+/K+-ATPase. Human MBG is significantly increased in end-stage renal disease and immunization against MBG attenuates cardiovascular fibrosis in a rat model of ...
Martin H Keppel, Grzegorz Piecha, Winfried März, Janne Cadamuro, Simon Auer, Thomas K Felder, Cornelia Mrazek, Hannes Oberkofler, Christian Trummer, Martin R Grübler, Verena Schwetz, Nicolas Verheyen, Marlene Pandis, Valentin Borzan, Elisabeth Haschke-Becher, Andreas Tomaschitz, Stefan Pilz   +16 more
doaj   +1 more source