Results 21 to 30 of about 606 (121)

Marinobufagenin, Left Ventricular Hypertrophy and Residual Renal Function in Kidney Transplant Recipients. [PDF]

J Clin Med, 2023
Background: Left ventricular hypertrophy (LVH), which is a pervasive complication of end-stage kidney disease (ESKD), persists in some uremic individuals even after kidney transplantation (Ktx), contributing to worsening CV outcomes. Marinobufagenin (MBG)
Bolignano D, Greco M, Presta P, Caglioti A, Carullo N, Zicarelli M, Foti DP, Dragone F, Andreucci M, Coppolino G.   +9 more
europepmc   +2 more sources

Quantification and impact of circulating cardiotonic steroids in the RATE-AF randomised trial of patients with atrial fibrillation and heart failure [PDF]

BMC Medicine
Background The presence and role of endogenous digoxin-like cardiotonic steroids (CTS) in humans is controversial. This study utilises a novel pipeline to quantify CTS and examines their interaction with digoxin within a randomised trial.
Ioannis Akoumianakis, Lorna C. Gilligan, Karina V. Bunting, Dannie Fobian, Paulus Kirchhof, Wiebke Arlt, Angela E. Taylor, Davor Pavlovic, Dipak Kotecha, Rate control Therapy Evaluation in permanent Atrial Fibrillation (RATE-AF) trial team   +9 more
doaj   +2 more sources

Chemistry and the Potential Antiviral, Anticancer, and Anti-Inflammatory Activities of Cardiotonic Steroids Derived from Toads [PDF]

Molecules, 2022
Cardiotonic steroids (CTS) were first documented by ancient Egyptians more than 3000 years ago. Cardiotonic steroids are a group of steroid hormones that circulate in the blood of amphibians and toads and can also be extracted from natural products such ...
Hesham R. El-Seedi, Nermeen Yosri, Bishoy El-Aarag, Shaymaa H. Mahmoud, Ahmed Zayed, Ming Du, Aamer Saeed, Syed G. Musharraf, Islam M. El-Garawani, Mohamed R. Habib, Haroon Elrasheid Tahir, Momtaz M. Hegab, Xiaobo Zou, Zhiming Guo, Thomas Efferth, Shaden A. M. Khalifa   +15 more
doaj   +2 more sources

Rapamycin Attenuates Cardiac Fibrosis in Experimental Uremic Cardiomyopathy by Reducing Marinobufagenin Levels and Inhibiting Downstream Pro‐Fibrotic Signaling [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundExperimental uremic cardiomyopathy causes cardiac fibrosis and is causally related to the increased circulating levels of the cardiotonic steroid, marinobufagenin (MBG), which signals through Na/K‐ATPase. Rapamycin is an inhibitor of the serine/
Steven T. Haller, Yanling Yan, Christopher A. Drummond, Joe Xie, Jiang Tian, David J. Kennedy, Victoria Y. Shilova, Zijian Xie, Jiang Liu, Christopher J. Cooper, Deepak Malhotra, Joseph I. Shapiro, Olga V. Fedorova, Alexei Y. Bagrov   +13 more
doaj   +2 more sources

Oral digoxin effects on exercise performance, K+ regulation and skeletal muscle Na+,K+‐ATPase in healthy humans

The Journal of Physiology, Volume 600, Issue 16, Page 3749-3774, 15 August 2022., 2022
Abstract figure legend Digoxin specifically inhibits Na,K‐pumps in all tissues and in skeletal muscle, and thus could therefore impair cellular Na/K homeostasis, excitability and contractility. In heart failure patients, digoxin binds to and therefore reduces the Na,K‐pump content in skeletal muscle; this lower number of available functional Na,K‐pumps
Simon Sostaric, Aaron C. Petersen, Craig A. Goodman, Xiaofei Gong, Tai‐Juan Aw, Malcolm J. Brown, Andrew Garnham, Collene H. Steward, Kate T. Murphy, Kate A. Carey, James Leppik, Steve F. Fraser, David Cameron‐Smith, Henry Krum, Rodney J. Snow, Michael J. McKenna   +15 more
wiley   +1 more source

Correction to: Monoclonal Antibody to Marinobufagenin Downregulates TGFβ Profibrotic Signaling in Left Ventricle and Kidney and Reduces Tissue Remodeling in Salt‐Sensitive Hypertension [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
doaj   +2 more sources

Marinobufagenin and left ventricular mass in young adults: the African-PREDICT study [PDF]

, 2018
Background The endogenous steroidal inhibitor of sodium–potassium-dependent adenosine triphosphate and natriuretic hormone, marinobufagenin, plays a physiological role in ionic homeostasis.
Kruger, Ruan, Wei, Wen, Smith, Wayne, Schutte, Aletta E., Strauss, Michél   +4 more
core   +2 more sources

Na,K-ATPase as a target for endogenous cardiotonic steroids: What's the evidence?

Genes and Diseases, 2021
With an exception of few reports, the plasma concentration of ouabain and marinobufagenin, mostly studied cardiotonic steroids (CTS) assessed by immunoassay techniques, is less than 1 nM. During the last 3 decades, the implication of these endogenous CTS
Sergei N. Orlov, Artem M. Tverskoi, Svetlana V. Sidorenko, Larisa V. Smolyaninova, Olga D. Lopina, Nickolai O. Dulin, Elizaveta A. Klimanova   +6 more
doaj   +1 more source

Microvascular function in non-dippers: potential involvement of the salt sensitivity biomarker, marinobufagenin-the African-PREDICT study [PDF]

, 2020
Suppressed nighttime blood pressure dipping is associated with salt sensitivity and may increase the hemodynamic load on the microvasculature. The mechanism remains unknown whereby salt sensitivity may increase the cardiovascular risk of non-dippers ...
Wayne Smith, Wei, Wen, Smith, Wayne, Schutte, Aletta E., Alexei Y. Bagrov, Aletta E. Schutte, Strauss-Kruger, Michél, Bagrov, Alexei Y., Michél Strauss‐Kruger, Olga V. Fedorova, Wen Wei   +10 more
core   +1 more source

Ouabain Suppresses IL-6/STAT3 Signaling and Promotes Cytokine Secretion in Cultured Skeletal Muscle Cells

Frontiers in Physiology, 2020
The cardiotonic steroids (CTS), such as ouabain and marinobufagenin, are thought to be adrenocortical hormones secreted during exercise and the stress response. The catalytic α-subunit of Na,K-ATPase (NKA) is a CTS receptor, whose largest pool is located
Sergej Pirkmajer, Katja Bezjak, Urška Matkovič, Klemen Dolinar, Lake Q. Jiang, Katarina Miš, Katarina Gros, Kseniya Milovanova, Katja Perdan Pirkmajer, Katja Perdan Pirkmajer, Tomaž Marš, Leonid Kapilevich, Leonid Kapilevich, Alexander V. Chibalin   +13 more
doaj   +1 more source