Results 1 to 10 of about 606 (121)

Urinary Marinobufagenin in Patients with Non-Advanced Chronic Kidney Disease: A Cross-Sectional Study [PDF]

Medicina, 2023
Background and Objectives: The global prevalence of chronic kidney disease (CKD) is on the rise, posing important challenges for healthcare systems. Thus, the search for new factors potentially involved in the pathogenesis, progression and complications ...
Davide Bolignano, Marta Greco, Mario D’Agostino, Paola Cianfrone, Loredana Tripodi, Roberta Misiti, Mariateresa Zicarelli, Ludovica Ganino, Daniela Patrizia Foti, Michele Andreucci, Giuseppe Coppolino   +10 more
doaj   +5 more sources

Very low urinary marinobufagenin excretion reflects a high risk of disease progression in non-advanced CKD [PDF]

Frontiers in Physiology
BackgroundChronic kidney disease (CKD) has now reached pandemic proportions but risk prediction towards end-stage kidney disease (ESKD) remains challenging. Kidney fibrosis is a key determinant in the transition from CKD to ESKD.
Davide Bolignano, Davide Bolignano, Marta Greco, Marta Greco, Loredana Tripodi, Mario D’Agostino, Paola Cianfrone, Roberta Misiti, Roberta Misiti, Sara Pugliese, Mariateresa Zicarelli, Michela Musolino, Michela Musolino, Daniela Patrizia Foti, Daniela Patrizia Foti, Michele Andreucci, Michele Andreucci, Giuseppe Coppolino, Giuseppe Coppolino   +18 more
doaj   +6 more sources

Marinobufagenin Inhibits Neutrophil Migration and Proinflammatory Cytokines

Journal of Immunology Research, 2019
Cardiotonic steroids, such as ouabain and digoxin, are known to bind to Na+/K+-ATPase and to promote several biological activities, including anti-inflammatory activity.
Deyse C. M. Carvalho, Luiz Henrique Agra Cavalcante-Silva, Éssia de A. Lima, José G. F. M. Galvão, Anne K. de A. Alves, Priscilla R. O. Feijó, Luís E. M. Quintas, Sandra Rodrigues-Mascarenhas   +7 more
doaj   +3 more sources

Silencing of PKG1 Gene Mimics Effect of Aging and Sensitizes Rat Vascular Smooth Muscle Cells to Cardiotonic Steroids: Impact on Fibrosis and Salt Sensitivity [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background Marinobufagenin, NKA (Na/K‐ATPase) inhibitor, causes vasoconstriction and induces fibrosis via inhibition of Fli1 (Friend leukemia integration‐1), a negative regulator of collagen synthesis.
Olga V. Fedorova, Victoria Y. Shilova, Valentina Zernetkina, Ondrej Juhasz, Wen Wei, Edward G. Lakatta, Alexei Y. Bagrov   +6 more
doaj   +3 more sources

Influence of Endogenous Cardiac Glycosides, Digoxin, and Marinobufagenin in the Physiology of Epithelial Cells

Cardiology Research and Practice, 2019
Cardiac glycosides are a group of compounds widely known for their action in cardiac tissue, some of which have been found to be endogenously produced (ECG).
Alejandro Ogazon del Toro, Lidia Jimenez, Lorena Hinojosa, Jacqueline Martínez-Rendón, Aida Castillo, Marcelino Cereijido, Arturo Ponce   +6 more
doaj   +3 more sources

Endogenous Bufadienolides, Fibrosis and Preeclampsia

Cardiology Research and Practice, 2019
Frequency of preeclampsia has no tendency to decrease, and it still takes the leading position in the structure of maternal mortality and morbidity worldwide.
Vitaliy A. Reznik, Vladimir A. Kashkin, Natalia I. Agalakova, C. David Adair, Alexei Y. Bagrov   +4 more
doaj   +3 more sources

Differences in morphology and in composition and release of parotoid gland secretion in introduced cane toads (Rhinella marina) from established populations in Florida, USA

Ecology and Evolution, 2021
Cane toads are highly toxic bufonids invasive in several locations throughout the world. Although physiological changes and effects on native predators for Australian populations have been well documented, Florida populations have received little ...
Steven T. Gardner, Megen Kepas, Casey R. Simons, Logan M. Horne, Alan H. Savitzky, Mary T. Mendonça   +5 more
doaj   +2 more sources

Marinobufagenin inhibits glioma growth through sodium pump α1 subunit and ERK signaling‐mediated mitochondrial apoptotic pathway

Cancer Medicine, 2018
Malignant glioma is one of the most challenging central nervous system diseases to treat and has high rates of recurrence and mortality. Current therapies often fail to control tumor progression or improve patient survival.
Yu‐Long Lan, Xun Wang, Jia‐Cheng Lou, Jin‐Shan Xing, Shuang Zou, Zhen‐Long Yu, Xiao‐Chi Ma, Hongjin Wang, Bo Zhang   +8 more
doaj   +2 more sources

Monoclonal Antibody to Marinobufagenin Downregulates TGFβ Profibrotic Signaling in Left Ventricle and Kidney and Reduces Tissue Remodeling in Salt‐Sensitive Hypertension

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Elevated levels of an endogenous Na/K‐ATPase inhibitor marinobufagenin accompany salt‐sensitive hypertension and are implicated in cardiac fibrosis. Immunoneutralization of marinobufagenin reduces blood pressure in Dahl salt‐sensitive (Dahl‐S)
Yongqing Zhang, Wen Wei, Victoria Shilova, Natalia N. Petrashevskaya, Valentina I. Zernetkina, Yulia N. Grigorova, Courtney A. Marshall, Rachel C. Fenner, Elin Lehrmann, William H. Wood, Kevin G. Becker, Edward G. Lakatta, Alexei Y. Bagrov, Olga V. Fedorova   +13 more
doaj   +3 more sources

Altered circulating marinobufagenin levels and recurrent intradialytic hypotensive episodes in chronic hemodialysis patients: a pilot, prospective study

Reviews in Cardiovascular Medicine, 2021
Intradialytic hypotension (IDH) is a sudden and often serious complication of chronic hemodialysis (HD). In this prospective study, we aimed at evaluating the clinical predictors of IDH in a homogeneous cohort of chronic HD patients, with a particular
Davide Bolignano, Marta Greco, Pierangela Presta, Giuseppina Crugliano, Jolanda Sabatino, Nazareno Carullo, Roberta Arena, Isabella Leo, Alessandro Comi, Michele Andreucci, Francesco Dragone, Antonio Strangio, Ciro Indolfi, Daniela Patrizia Foti, Salvatore De Rosa, Giuseppe Coppolino   +15 more
doaj   +1 more source