Chemistry and the Potential Antiviral, Anticancer, and Anti-Inflammatory Activities of Cardiotonic Steroids Derived from Toads [PDF]
Molecules, 2022 Cardiotonic steroids (CTS) were first documented by ancient Egyptians more than 3000 years ago. Cardiotonic steroids are a group of steroid hormones that circulate in the blood of amphibians and toads and can also be extracted from natural products such ...
Hesham R. El-Seedi +15 more
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Na+,K+-ATPase and Cardiotonic Steroids in Models of Dopaminergic System Pathologies [PDF]
Biomedicines, 2023 In recent years, enough evidence has accumulated to assert that cardiotonic steroids, Na+,K+-ATPase ligands, play an integral role in the physiological and pathophysiological processes in the body.
Alisa A. Markina +8 more
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Endogenous Mammalian Cardiotonic Steroids—A New Cardiovascular Risk Factor?—A Mini-Review [PDF]
Life, 2021 The role of endogenous mammalian cardiotonic steroids (CTS) in the physiology and pathophysiology of the cardiovascular system and the kidneys has interested researchers for more than 20 years. Cardiotonic steroids extracted from toads or plants, such as
Natalia Słabiak-Błaż, Grzegorz Piecha
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Broad Spectrum Antiviral Properties of Cardiotonic Steroids Used as Potential Therapeutics for Emerging Coronavirus Infections [PDF]
Pharmaceutics, 2021 Cardiotonic steroids are steroid-like natural compounds known to inhibit Na+/K+-ATPase pumps. To develop a broad-spectrum antiviral drug against the emerging coronavirus infection, this study assessed the antiviral properties of these compounds.
Young-Hee Jin +8 more
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Research Progress in Pharmacological Activities and Applications of Cardiotonic Steroids [PDF]
Frontiers in Pharmacology, 2022 Cardiotonic steroids (CTS) are a group of compounds existing in animals and plants. CTS are commonly referred to cardiac glycosides (CGs) which are composed of sugar residues, unsaturated lactone rings and steroid cores.
Junwei Ren +4 more
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Na,K-ATPase as a target for endogenous cardiotonic steroids: What's the evidence? [PDF]
Genes and Diseases, 2021 With an exception of few reports, the plasma concentration of ouabain and marinobufagenin, mostly studied cardiotonic steroids (CTS) assessed by immunoassay techniques, is less than 1 nM. During the last 3 decades, the implication of these endogenous CTS
Sergei N. Orlov +6 more
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Mechanisms mediating effects of cardiotonic steroids in mammalian blood cells [PDF]
Frontiers in PharmacologyCardiotonic steroids (CTSs) were known as steroidal plant compounds that exert cellular effects by the binding to Na,K-ATPase. Earlier, plant (exogenous) CTSs were used to treat chronic heart failure.
Yuri M. Poluektov +6 more
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Impact of the diverse cardiotonic steroids on beta-amyloid precursor protein level [PDF]
Frontiers in PharmacologyEndogenous cardiotonic steroids (CTS), which are specific ligands of Na,K-ATPase, have been detected not only in blood plasma but also in cerebrospinal fluid and in the brain tissue.
Irina Yu. Petrushanko +7 more
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Ouabain‐induced hypertension in rats: Mechanisms, variability and translational implications
Experimental PhysiologyOuabain‐induced hypertension is a multifactorial and condition‐dependent phenomenon involving coordinated actions across vascular, renal and central nervous system pathways.
Priscilla Rodrigues O. Feijó +1 more
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Erysimum cheiri: The potential uterotonic medicinal herb [PDF]
Trends in Pharmaceutical Sciences, 2020 Wallflower (Erysimum cheiri (L.) Crantz) belonging to the family Brassicaceae has been a well-known medicinal herb in Persian medicine. Several cardiotonic steroids have isolated from different parts of this plant.
Ghazaleh Mosleh +3 more
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