Discovery of Ro 41‐0960, a Non‐Steroidal Inhibitor of the Na+/K+‐ATPase [PDF]
ChemMedChem, Volume 21, Issue 17, 14 September 2026.Ro 41‐0960 is a non‐steroidal Na+/K+‐ATPase inhibitor with low micromolar potency and a mixed inhibitory mechanism distinct from classical cardiotonic steroids, without acute pro‐arrhythmic effects in human cardiomyocytes. The Na+/K+‐ATPase (NKA) is a central regulator of cardiac ion homeostasis and a validated target for heart failure.
Carlos Cruz‐Cortés +5 more
wiley +2 more sources
Modular Total Synthesis and Cell-Based Anticancer Activity Evaluation of Ouabagenin and Other Cardiotonic Steroids with Varying Degrees of Oxygenation. [PDF]
J Am Chem Soc, 2019 A Cu(II)-catalyzed diastereoselective Michael/aldol cascade approach is used to accomplish concise total syntheses of cardiotonic steroids with varying degrees of oxygenation including cardenolides ouabagenin, sarmentologenin, 19-hydroxysarmentogenin ...
Khatri HR +6 more
europepmc +2 more sources
Na/K-ATPase in the renal proximal tubule cell: classic & novel roles in sodium handling [PDF]
Frontiers in PhysiologyThe cell membrane Na/K-ATPase (NKA), the archetypal P-type ATPase, is the enzymatic complex that hydrolyzes ATP to transport Na+ and K+ against their transmembrane electrochemical gradients.
Kristiana Sklioutovskaya-Lopez +8 more
doaj +2 more sources
Neuroinflammation and Neutrophils: Modulation by Ouabain
Frontiers in Pharmacology, 2022 Cardiotonic steroids are natural compounds that present many physiological and pharmacological functions. They bind Na+/K+-ATPase (NKA) modifying cellular ion concentration and trigger cell signaling mechanisms without altering ion balance.
Jacqueline Alves Leite +5 more
doaj +1 more source
Cannogenol and Related Cardiotonic Steroids: Concise Synthesis and their Anticancer Activity Evaluation [PDF]
, 2018 Small molecules that are approved as drugs are largely the result of extensive synthetic efforts. A robust synthetic method is required to access the natural products and their analogs to study their biological activities.
Bhattarai, Bijay
core +7 more sources
Cells, 2023 Na/K-ATPase maintains transmembrane ionic gradients and acts as a signal transducer when bound to endogenous cardiotonic steroids. At subnanomolar concentrations, ouabain induces neuroprotection against calcium overload and apoptosis of neurons during ...
Dmitry A. Sibarov +6 more
doaj +1 more source
Effect of ouabain on calcium signaling in rodent brain: A systematic review of in vitro studies
Frontiers in Pharmacology, 2022 The Na+/K+-ATPase is an integral membrane ion pump, essential to maintaining osmotic balance in cells in the presence of cardiotonic steroids; more specifically, ouabain can be an endogenous modulator of the Na+/K+-ATPase. Here, we conducted a systematic
Jacqueline Alves Leite +8 more
doaj +1 more source
Steroids—has the time come to extend their use to AML?
Journal of the Egyptian National Cancer Institute, 2021 Background In 2018, leukaemia accounted for 2.6% of all new cancers, it being the 13th most common cause of cancer and the 10th most common cause of cancer death. Glucocorticoids are commonly used in lymphoid leukaemia treatment, where they are cytotoxic.
Mariah Farrugia +3 more
doaj +1 more source
Assessing cardiotonic steroids involvement in hypertensive rat models with Helicobacter pylori infections [PDF]
, 2020 Dissertation (MSc)--University of Pretoria 2020.Introduction: Hypertension is an important public health challenge worldwide, being the leading cause of cardiovascular disease, morbidity and mortality.
core +1 more source
Na/K-ATPase amplification of oxidant stress; a universal but unrecognized clinical target?
Marshall Journal of Medicine, 2016 The Na/K-ATPase has a signaling function which appears to be separate from its ion pumping function. This signaling function refers to the transduction of conformational changes in the Na/K-ATPase alpha1 subunit into activating Src’s tyrosine kinase ...
Zijian Xie, Joseph I. Shapiro
doaj +1 more source