Transcription-Driven Repurposing of Cardiotonic Steroids for Lithium Treatment of Severe Depression [PDF]
CellsLithium is prescribed as a mood stabilizer for bipolar disorder and severe depression. However, the mechanism of action of lithium is unknown and there are major side effects associated with prolonged medication.
Richard Killick +7 more
doaj +5 more sources
Cardiotonic Steroids as Modulators of Neuroinflammation [PDF]
Frontiers in Endocrinology, 2016 Cardiotonic steroids (CTS) are a class of specific ligands of the Na+,K+- ATPase (NKA). NKA is a P-type ATPase that is ubiquitously expressed and although well known to be responsible for the maintenance of the cell electrochemical gradient through ...
Ana Maria Marques Orellana +4 more
doaj +4 more sources
Synthesis of Cardiotonic Steroids Oleandrigenin and Rhodexin B. [PDF]
J Org Chem, 2021 This article describes a concise synthesis of cardiotonic steroids oleandrigenin (7) and its subsequent elaboration into the natural product rhodexin B (2) from the readily available intermediate (8) that could be derived from the ...
Fejedelem Z, Carney N, Nagorny P.
europepmc +4 more sources
A Short Review on Cardiotonic Steroids and Their Aminoguanidine Analogues
Molecules, 2000 A short review on cardiotonic steroids and their analogues is presented. The natural, semisynthetic and synthetic derivatives, as well as their mechanism of action and structure-activity relationships are shown, with a special reference to aminoguanidine
Arturo San Feliciano +2 more
doaj +2 more sources
Endogenous cardiotonic steroids and cardiovascular disease, where to next? [PDF]
Cell Calcium, 2020 Ever since British Physician William Withering first described the use of foxglove extract for treatment of patients with congestive heart failure in 1785, cardiotonic steroids have been used clinically to treat heart failure and more recently atrial ...
Pavlovic D.
europepmc +2 more sources
A real-time PCR method to genotype mutant mouse models with altered affinity for cardiotonic steroids on the Na,K-ATPase [PDF]
PLoS ONE, 2022 The highly conserved, cardiotonic steroid binding site (also termed ouabain binding site) on the primary α subunit of Na,K-ATPase plays a receptor signaling role in a range of vital cell processes and is a therapeutic target for human disease.
Peter W. Chomczynski +3 more
doaj +3 more sources
Cardiotonic Steroids as a Potential Novel Approach for Immunomodulation in Inflammatory Bowel Disease. [PDF]
J Clin MedInflammatory bowel disease (IBD) is a chronic condition that significantly impairs the quality of life of millions of individuals. The pathogenesis of IBD is closely linked to dysbiosis of microbiota and the activation of various inflammatory pathways ...
Cavalcante-Silva LHA +5 more
europepmc +2 more sources
Probing the stereoselectivity of OleD-catalyzed glycosylation of cardiotonic steroids. [PDF]
RSC Adv, 2018 The glycosyltransferase OleD variant as a catalyst for the glycosylation of four pairs of epimers of cardiotonic steroids (CTS) was assessed.
Zhu XL +8 more
europepmc +2 more sources
Cardiotonic Steroids-A Possible Link Between High-Salt Diet and Organ Damage. [PDF]
Int J Mol Sci, 2019 High dietary salt intake has been listed among the top ten risk factors for disability-adjusted life years. We discuss the role of endogenous cardiotonic steroids in mediating the dietary salt-induced hypertension and organ ...
Paczula A, Wiecek A, Piecha G.
europepmc +2 more sources
Quantification and impact of circulating cardiotonic steroids in the RATE-AF randomised trial of patients with atrial fibrillation and heart failure [PDF]
BMC MedicineBackground The presence and role of endogenous digoxin-like cardiotonic steroids (CTS) in humans is controversial. This study utilises a novel pipeline to quantify CTS and examines their interaction with digoxin within a randomised trial.
Ioannis Akoumianakis +9 more
doaj +2 more sources