Results 31 to 40 of about 86,211 (132)

Inhibition of SARS-CoV-2 by Highly Potent Broad-Spectrum Anti-Coronaviral Tylophorine-Based Derivatives

Frontiers in Pharmacology, 2020
Tylophorine-based compounds and natural cardiotonic steroids (cardenolides and bufadienolides) are two classes of transmissible gastroenteritis coronavirus inhibitors, targeting viral RNA and host cell factors, respectively.
Cheng-Wei Yang, Yue-Zhi Lee, Hsing-Yu Hsu, Jia-Tsrong Jan, Yi-Ling Lin, Sui-Yuan Chang, Tzu-Ting Peng, Ruey-Bing Yang, Jian-Jong Liang, Chun-Che Liao, Tai-Ling Chao, Yu-Hau Pang, Han-Chieh Kao, Wen-Zheng Huang, Jiunn-Horng Lin, Chun-Ping Chang, Guang-Hao Niu, Szu-Huei Wu, Huey-Kang Sytwu, Chiung-Tong Chen, Shiow-Ju Lee   +20 more
doaj   +1 more source

Cardiotonic Steroids Suppress Adenovirus Replication [PDF]

, 2018
Human adenoviruses are common pathogens that can cause life-threatening illness, yet no approved therapies are available for treatment. This work shows that two cardiotonic steroids, digoxin and digitoxin, inhibit adenovirus replication in A549 lung ...
Grosso, Filomena Sarina
core   +1 more source

21-Benzylidene digoxin: a proapoptotic cardenolide of cancer cells that up-regulates Na,K-ATPase and epithelial tight junctions.

PLoS ONE, 2014
Cardiotonic steroids are used to treat heart failure and arrhythmia and have promising anticancer effects. The prototypic cardiotonic steroid ouabain may also be a hormone that modulates epithelial cell adhesion. Cardiotonic steroids consist of a steroid
Sayonarah C Rocha, Marco T C Pessoa, Luiza D R Neves, Silmara L G Alves, Luciana M Silva, Herica L Santos, Soraya M F Oliveira, Alex G Taranto, Moacyr Comar, Isabella V Gomes, Fabio V Santos, Natasha Paixão, Luis E M Quintas, François Noël, Antonio F Pereira, Ana C S C Tessis, Natalia L S Gomes, Otacilio C Moreira, Ruth Rincon-Heredia, Fernando P Varotti, Gustavo Blanco, Jose A F P Villar, Rubén G Contreras, Leandro A Barbosa   +23 more
doaj   +1 more source

Potential Effects and Mechanisms of Action of Topical Wallflower (Erysimum cheiri (L.) Cranz) Administration in Anal Fissure [PDF]

Research Journal of Pharmacognosy, 2018
Anal fissure is an ischemic ulcer that occurs in anoderm and it has no obvious etiology and pathophysiology in current medicine. Anal fissure has a profound history in Persian and Persian medicine and wallflower (Erysimum cheiri (L.) Crantz) has been a ...
Ghazaleh Mosleh, Parmis Badr, Zohreh Abolhassanzadeh, Seyed Vahid Hosseini, Abdolali Mohagheghzadeh, Amir Azadi*   +5 more
doaj   +1 more source

Ouabain-Induced Gene Expression Changes in Human iPSC-Derived Neuron Culture Expressing Dopamine and cAMP-Regulated Phosphoprotein 32 and GABA Receptors

Brain Sciences, 2021
Cardiotonic steroids (CTS) are specific inhibitors and endogenous ligands of a key enzyme in the CNS—the Na+, K+-ATPase, which maintains and creates an ion gradient on the plasma membrane of neurons. CTS cause the activation of various signaling cascades
Alexander V. Lopachev, Maria A. Lagarkova, Olga S. Lebedeva, Margarita A. Ezhova, Rogneda B. Kazanskaya, Yulia A. Timoshina, Anastasiya V. Khutorova, Evgeny E. Akkuratov, Tatiana N. Fedorova, Raul R. Gainetdinov   +9 more
doaj   +1 more source

Antiviral activity of ouabain against a Brazilian Zika virus strain

Scientific Reports, 2022
Zika virus (ZIKV) is an emerging arbovirus associated with neurological disorders. Currently, no specific vaccines or antivirals are available to treat the ZIKV infection.
Deyse Cristina Madruga Carvalho, Poliana Gomes da Silva, Willyenne Marília Dantas, Severino Jefferson Ribeiro da Silva, Caroline Targino Alves da Silva, Elton José Ferreira Chaves, Demetrius Antônio Machado de Araújo, Ronaldo Nascimento de Oliveira, Sandra Rodrigues-Mascarenhas, Lindomar José Pena   +9 more
doaj   +1 more source

Binding of sodium ions and cardiotonic steroids to native and selectively trypsinized Na,K pump, detected by charge movements

, 1994
A fluorescent dye, RH421, has been used to characterize charge movements associated with cation and cardiotonic steroid binding to Na,K-ATPase and to a specifically trypsinized preparation, so-called '19-kDa membranes.' A fluorescence decrease induced by
Apell, Hans Jürgen, Karlish, Steven J D, Schwappach, Blanche, Stürmer, Werner   +3 more
core   +9 more sources

Na/K-ATPase Signaling and Salt Sensitivity: The Role of Oxidative Stress

Antioxidants, 2017
Other than genetic regulation of salt sensitivity of blood pressure, many factors have been shown to regulate renal sodium handling which contributes to long-term blood pressure regulation and have been extensively reviewed.
Jiang Liu, Yanling Yan, Ying Nie, Joseph I. Shapiro   +3 more
doaj   +1 more source

Isolation and Characterization of Cardiotonic Steroids from the Bulb of Urginea altissima BAKER [PDF]

, 1979
Six cardiotonic steroids were isolated from bulbs of Urginsa altissima BAKER and identified as hellebrigenin, scilliglaucosidin, scilliglaucosidin-3-one, altoside, hellebrigenin β-D-glicoside, and scilliglaucosidin α-L-rhamnoside ...
26580, 26582, 26581, Umezawa, Keiko, Kupchan, S. Morris, 26431, Shimada, Kazutake, 90004605, Nambara, Toshio   +8 more
core   +2 more sources

Bioinspired Synthesis of Twin abeo‐Steroids Bufogargarizins A and B via a Divergent Intramolecular Aldol Addition Reaction

Angewandte Chemie, Volume 138, Issue 2, 9 January 2026.
Twin natural products. This manuscript describes a concise biomimetic synthesis of twin abeo‐steroids bufogargarizins A and B with an unusual [7.5.6.5] and [5.7.6.5] skeletons in 19 steps (LLS). The described synthetic approach features the application of a bioinspired regiodivergent intramolecular aldol addition reaction and a selective singlet oxygen‐
Zoey J. Surma, Volodymyr Hiiuk, Eugene Zviagin, Yaxin Ouyang, Alex Chacko, Fengrui Qu, Paul M. Zimmerman, Pavel Nagorny   +7 more
wiley   +2 more sources