Results 31 to 40 of about 606 (121)

Marinobufagenin, resibufogenin and preeclampsia [PDF]

, 2010
The bufodienolides are cardiac glycosides which have the ability to inhibit the enzyme, Na+/K+ ATPase (sodium potassium adenosine triphosphatase). They are cardiac inotropes, cause vasoconstriction (and, potentially, hypertension) and are natriuretic ...
Uddin, M.N., Puschett, J.B., Agunanne, E.   +2 more
core   +1 more source

Effect of miR‐29b on the Proliferation and Apoptosis of Pulmonary Artery Smooth Muscle Cells by Targeting Mcl‐1 and CCND2

BioMed Research International, Volume 2018, Issue 1, 2018., 2018
The proliferation and apoptosis of pulmonary artery smooth muscle cells (PASMCs) are considered to be key steps in the progression of pulmonary arterial hypertension (PAH). MicroRNAs (e.g., miR‐29b) have been identified in various diseases to be critical modulators of cell growth and apoptosis by targeting Mcl‐1 and CCND2.
Juan Chen, Yanping Li, Yun Li, Lijian Xie, Jianyi Wang, Yongwei Zhang, Tingting Xiao, Sung-Hoon Kim   +7 more
wiley   +1 more source

P81 Antibody to Cardiotonic Steroid Reduces Blood Pressure and Vascular Fibrosis in Preeclampsia

Artery Research, 2020
Background: Previous studies implicated cardiotonic steroids, including Na/K-ATPase inhibitor marinobufagenin (MBG), in the pathogenesis of preeclampsia (PE). We demonstrated that MBG induces fibrosis via mechanism involving inhibition of Fli1, a nuclear
NI Agalakova, VA Reznik, OV Nadei, IA Ershov, OS Rassokha, ML Vasyutina, MM Galagudza, AY Bagrov   +7 more
doaj   +1 more source

Evaluating the Cancer Therapeutic Potential of Cardiac Glycosides

BioMed Research International, Volume 2014, Issue 1, 2014., 2014
Cardiac glycosides, also known as cardiotonic steroids, are a group of natural products that share a steroid‐like structure with an unsaturated lactone ring and the ability to induce cardiotonic effects mediated by a selective inhibition of the Na+/K+‐ATPase.
José Manuel Calderón-Montaño, Estefanía Burgos-Morón, Manuel Luis Orta, Dolores Maldonado-Navas, Irene García-Domínguez, Miguel López-Lázaro, Gautam Sethi   +6 more
wiley   +1 more source

Placental Vacuolar ATPase Function Is a Key Link between Multiple Causes of Preeclampsia

International Scholarly Research Notices, Volume 2013, Issue 1, 2013., 2013
Preeclampsia, a relatively common pregnancy disorder, is one of the major causes of maternal and fetal morbidity and mortality. Despite numerous research, the etiology of this syndrome remains not well understood as the pathogenesis of preeclampsia is complex, involving interaction between genetic, immunologic, and environmental factors.
Dongxin Zhang, Duyun Ye, Hongxiang Chen, M. Friedrich, N. A. Ginsberg, C. Iavazzo, S. Palomba, K. Yang   +7 more
wiley   +1 more source

Reactive Oxygen Species Modulation of Na/K‐ATPase Regulates Fibrosis and Renal Proximal Tubular Sodium Handling

International Journal of Nephrology, Volume 2012, Issue 1, 2012., 2012
The Na/K‐ATPase is the primary force regulating renal sodium handling and plays a key role in both ion homeostasis and blood pressure regulation. Recently, cardiotonic steroids (CTS)‐mediated Na/K‐ATPase signaling has been shown to regulate fibrosis, renal proximal tubule (RPT) sodium reabsorption, and experimental Dahl salt‐sensitive hypertension in ...
Jiang Liu, David J. Kennedy, Yanling Yan, Joseph I. Shapiro, Ayse Balat   +4 more
wiley   +1 more source

4.8 PLACENTAL NA/K-ATPASE INHIBITOR MARINOBUFAGENIN INDUCES ARTERIAL WALL FIBROSIS IN PREECLAMPSIA

Artery Research, 2018
Background: Previous studies implicated cardiotonic steroids, including Na/K-ATPase inhibitor marinobufagenin (MBG), in the pathogenesis of preeclampsia (PE). Immunoneutralization of heightened MBG by Digibind, a digoxin antibody, reduces blood pressure (
Olga Fedorova, Natalia Aglakova, Yulia Grigorova, Vitalily Reznik, Valintina Zernetkina, Wen Wei, Edward Lakatta, Alexei Bagrov   +7 more
doaj   +1 more source

Ouabain‐induced hypertension in rats: Mechanisms, variability and translational implications

Experimental Physiology, Volume 111, Issue 3, Page 653-673, 1 March 2026.
Abstract Ouabain‐induced hypertension is a multifactorial and condition‐dependent phenomenon involving coordinated actions across vascular, renal and central nervous system pathways. At the vascular level, ouabain inhibits Na⁺/K⁺‐ATPase, particularly the α2‐isoform, leading to elevated intracellular Ca2⁺, enhanced vasoconstriction and structural ...
Priscilla Rodrigues O. Feijó, Luis Eduardo M. Quintas   +1 more
wiley   +1 more source

Canrenone Restores Vasorelaxation Impaired by Marinobufagenin in Human Preeclampsia

, 2022
Previous studies implicated cardiotonic steroids, including Na/K-ATPase inhibitor marinobufagenin (MBG), in the pathogenesis of preeclampsia (PE). Recently, we demonstrated that (i) MBG induces fibrosis in rat tissues via a mechanism involving Fli1, a ...
Natalia I. Agalakova, Yulia N. Grigorova, Larisa A. Romanova, Elena V. Mikhailova, C. David Adair, Irina V. Romanova, Vitaly A. Reznik, Ivan A. Ershov, Olga V. Nadei, Alexei Y. Bagrov, Leticia Samuilovskaya   +10 more
core   +1 more source

Identification of marinobufagenin in plasma as a promising LC-MS assay for preeclampsia risk assessment [PDF]

, 2014
Marinobufagenin (MBG) is a bufadienolide compound belonging to the cardiac glycoside class and is present in humans as well as in some plants and other animals.
Bond, Liz, Blankert, Bertrand, Tuytten, Robin, Lenaerts, Charline   +3 more
core   +1 more source