Ca2+-Driven Selectivity of the Effect of the Cardiotonic Steroid Marinobufagenin on Rabbit Sinoatrial Node Function [PDF]
Cells, 2023 The synergy between Na+-K+ pumps, Na+-Ca2+ exchangers, membrane currents and the sarcoplasmic reticulum (SR) generates the coupled-clock system, which governs the spontaneous electrical activity of heart sinoatrial node cells (SANCs).
Sofia Segal, Yael Yaniv
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Neutralization of Marinobufagenin Demonstrates Efficacy In Vitro and In Vivo in Models of Pre-Eclampsia [PDF]
BiomedicinesBackground/Objectives: Marinobufagenin (MBG) is a biomarker that is found to be high in pre-eclampsia (preE), and thus is relevant in the pathogenesis of obstetric complications.
Ahmed F. Pantho +8 more
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Endogenous bufadienolides, mineralocorticoid receptor antagonists and fibrosis in chronic kidney disease [PDF]
Frontiers in PharmacologyEvery year millions die prematurely of complications related to chronic kidney disease (CKD). Main causes of death are connected with cardiovascular (CV) complications.
Mai Rosenberg, Alexei Y. Bagrov
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Mechanism of Marinobufagenin-Induced Hyperpermeability of Human Brain Microvascular Endothelial Cell Monolayer: A Potential Pathogenesis of Seizure in Preeclampsia [PDF]
CellsPreeclampsia (preE) is a hypertensive disorder in pregnancies. It is the third leading cause of mortality among pregnant women and fetuses worldwide, and there is much we have yet to learn about its pathophysiology.
Ahmed F. Pantho +8 more
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Impact of the diverse cardiotonic steroids on beta-amyloid precursor protein level [PDF]
Frontiers in PharmacologyEndogenous cardiotonic steroids (CTS), which are specific ligands of Na,K-ATPase, have been detected not only in blood plasma but also in cerebrospinal fluid and in the brain tissue.
Irina Yu. Petrushanko +7 more
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Journal of Experimental Neuroscience, 2015 The evaluation of concussed athletes, including testing to determine if and when they may return to play, has become an important task of athletic trainers and team physicians.
Joel Oliver +8 more
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Bufalin‐Induced Epithelial‐to‐Mesenchymal Transition in Kidney Epithelial Cells [PDF]
Cell Biology International, Volume 49, Issue 12, Page 1764-1786, December 2025.ABSTRACT The kidney plays a central role in fluid, electrolyte, and blood pressure regulation, processes tightly coupled to Na⁺/K⁺‐ATPase activity. Beyond its canonical transport function, Na⁺/K⁺‐ATPase also acts as a signaling receptor for cardiotonic steroids (CTSs) such as bufalin, which have been implicated in fibrosis and epithelial‐to‐mesenchymal
Gabriela Morais de Oliveira Barros +3 more
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Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017 BackgroundWe have investigated serum levels of immunoreactive marinobufagenin (MBG) in 16‐ to 20‐week‐old spontaneously hypertensive rats (SHRs)‐A3 and in the normotensive Wistar‐Kyoto (WKY) rat strain in the absence of salt loading, and we have ...
Renata I. Dmitrieva +2 more
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Endogenous Mammalian Cardiotonic Steroids—A New Cardiovascular Risk Factor?—A Mini-Review [PDF]
Life, 2021 The role of endogenous mammalian cardiotonic steroids (CTS) in the physiology and pathophysiology of the cardiovascular system and the kidneys has interested researchers for more than 20 years. Cardiotonic steroids extracted from toads or plants, such as
Natalia Słabiak-Błaż, Grzegorz Piecha
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Perioperative Marinobufagenin (MBG) Measurement May Improve Acute Kidney Injury Risk Assessment in Patients Undergoing Major Cardiac Surgery: A Proof-of-Concept Study [PDF]
MedicinaBackground and Objectives: Acute kidney injury (AKI) remains a significant complication following major cardiac surgery. Marinobufagenin (MBG), a cardiotonic steroid involved in sodium balance and blood pressure regulation, has been linked to organ ...
Davide Bolignano +12 more
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