The need for more holistic immune profiling in next-generation SARS-CoV-2 vaccine trials
Frontiers in Immunology, 2022 First-generation anit-SARS-CoV-2 vaccines were highly successful. They rapidly met an unforeseen emergency need, saved millions of lives, and simultaneously eased the burden on healthcare systems worldwide. The first-generation vaccines, however, focused
Robert L. Murphy +8 more
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Emerging Microbes and Infections, 2020 Classical swine fever (CSF) is one of the most important viral diseases of pigs. In many countries, the use of vaccines is restricted due to limitations of subunit vaccines with regard to efficacy and onset of protection as well as failure of live ...
Alexander Postel, Paul Becher
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DIFFERENTIATION BETWEEN VIRAL INFECTED AND VACCINATED CHICKEN BY USE OF TETANUS TOXOID AS AN EXOGENOUS MARKER [PDF]
Veterinary Medical Journal - Giza, 2008 The present work was carried out to develop a simple and effective method for differentiating infected from vaccinated chickens to improve the control of infectious diseases.
AMANI A SALEH, ROUKAIA M OSMAN
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Removal of heterologous sequences from Plasmodium falciparum mutants using FLPe-recombinase. [PDF]
PLoS ONE, 2010 Genetically-modified mutants are now indispensable Plasmodium gene-function reagents, which are also being pursued as genetically attenuated parasite vaccines.
Ben C L van Schaijk +4 more
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Flavivirus NS1 and Its Potential in Vaccine Development
Vaccines, 2021 The Flavivirus genus contains many important human pathogens, including dengue, Japanese encephalitis (JE), tick-borne encephalitis (TBE), West Nile (WN), yellow fever (YF) and Zika (ZIK) viruses.
Kassandra L. Carpio, Alan D. T. Barrett
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Engineering more stable, selectable marker-free autoluminescent mycobacteria by one step. [PDF]
PLoS ONE, 2015 In our previous study, we demonstrated that the use of the autoluminescent Mycobacterium tuberculosis as a reporter strain had the potential to drastically reduce the time, effort, animals and costs consumed in evaluation of the activities of drugs and ...
Feng Yang +12 more
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Multiserotype protection elicited by a combinatorial prime-boost vaccination strategy against bluetongue virus. [PDF]
PLoS ONE, 2012 Bluetongue virus (BTV) belongs to the genus Orbivirus within the family Reoviridae. The development of vector-based vaccines expressing conserved protective antigens results in increased immune activation and could reduce the number of multiserotype ...
Eva Calvo-Pinilla +3 more
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Fluorescent-Antibody Marker for Vaccine-Induced Rubella Antibodies [PDF]
Infection and Immunity, 1970 Tests with LLC-MK2 and BHK-21 cells showed that the fluorescent-antibody (FA) procedure can be used to differentiate antibodies resulting from natural infection and antibodies stimulated by rubella vaccine virus. Negative or weak FA reactions in LLC-MK2 cells and strong reactions in BHK-21 cells indicated antibody stimulated by the vaccine virus ...
G C, Brown, T P, O'leary
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Long-Lasting T Cell Responses in BNT162b2 COVID-19 mRNA Vaccinees and COVID-19 Convalescent Patients
Frontiers in Immunology, 2022 The emergence of novel variants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has made it more difficult to prevent the virus from spreading despite available vaccines.
Antti Hurme +23 more
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Evaluation of first generation vaccines against human leishmaniasis and the implication of Leishmanin Skin Test (LST) response in disease prevalence [PDF]
, 2011 This study reports the detailed analysis of the data from ten different clinical trials of first generation prophylactic vaccines (FGV) against leishmaniasis.
Noazin, Sassan
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