Results 51 to 60 of about 78,970 (275)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Construction of Deletion-knockout Mutant Fowlpox Virus (FWPV)

Bio-Protocol, 2014
The construction of deletion-knockout poxviruses is a useful approach to determining the function of specific virus genes. This protocol is an adaptation of the transient dominant knockout selection protocol published by Falkner and Moss (1990) for use ...
Stephen Laidlaw, Michael Skinner
doaj   +1 more source

A simplified protocol for detecting two systemic bait markers (Rhodamine B and iophenoxic acid) in small mammals

, 2003
We developed a method of quantifying levels of fluorescence in the whiskers of wild stoats (Mustela erminea) using fluorescence microscopy and Axiovision 3.0.6.1 software. The method allows for discrimination between natural fluorescence present in or on
King, Carolyn M., Petcu, M., M. Petcu, Purdey, D. C., D. C. Purdey, C. M. King   +5 more
core   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Design and Estimation for Evaluating Principal Surrogate Markers in Vaccine Trials [PDF]

Biometrics, 2013
AbstractSummaryIn vaccine research, immune biomarkers that can reliably predict a vaccine's effect on the clinical endpoint (i.e., surrogate markers) are important tools for guiding vaccine development. This article addresses issues on optimizing two‐phase sampling study design for evaluating surrogate markers in a principal surrogate framework ...
Huang, Ying, Gilbert, Peter B., Wolfson, Julian   +2 more
openaire   +3 more sources

The Seroepidemiology of Haemophilus influenzae Type B Prior to Introduction of an Immunization Programme in Kathmandu, Nepal.

, 2014
Haemophilus influenzae type b (Hib) is now recognized as an important pathogen in Asia. To evaluate disease susceptibility, and as a marker of Hib transmission before routine immunization was introduced in Kathmandu, 71 participants aged 7 months-77 ...
Neelam Adhikari, Thorson, SM, Clutterbuck, EA, Marshall, AS, Gautam Samir C., Adhikari, N, Shrestha, S, Barker, CI, Andrew J. Pollard (44971), Shrestha Shrijana, Barker Charlotte I. S., Pollard Andrew J., Kelly Dominic F., Elizabeth A Clutterbuck, Dominic F. Kelly (301751), Samir C Gautam, Adhikari Neelam, Charlotte I S Barker, Clutterbuck Elizabeth A., Pulickal Anoop S., Shrijana Shrestha, Kibwana, E, Dominic F Kelly, Andrew J Pollard, Marshall Andrew S. J., Pulickal, AS, Gautam, SC, Andrew S J Marshall, Anoop S. Pulickal (512430), Anoop S Pulickal, Thorson Stephen M., Charlotte I. S. Barker (512429), Samir C. Gautam (301746), Kibwana Elizabeth, Stephen M Thorson, Elizabeth Kibwana (512431), Kelly, DF, Stephen M. Thorson (512433), Pollard, AJ, Neelam Adhikari (301753), Pollard, Andrew, Elizabeth Kibwana, Andrew S. J. Marshall (512428), Shrijana Shrestha (512434), Elizabeth A. Clutterbuck (512432)   +44 more
core   +1 more source

Effectiveness of influenza vaccine in aging and older adults: comprehensive analysis of the evidence [PDF]

, 2012
Foremost amongst the diseases preventable by vaccination is influenza. Worldwide, influenza virus infection is associated with serious adverse events leading to hospitalization, debilitating complications, and death in elderly individuals ...
Assir N, Lang, Pierre-Olivier, Govind, Sheila, Aspinall R, Mendes A, Mendes, Aline, Socquet, Jennifer, Govind S, Socquet J, Assir, Noémie, Lang PO, Aspinall, Richard   +11 more
core   +1 more source

A Prospective Study of Individuals at Risk of Multiple Sclerosis Informs the Design of Primary Prevention Studies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective In multiple sclerosis, the optimal time for deploying a therapeutic intervention is before the central nervous system is damaged; given the success of trials treating the earliest stage of MS, the radiologically isolated syndrome, developing primary prevention strategies is an important next challenge.
Amy W. Laitinen, Ceren Tozlu, Tina Roostaei, Fatoumata Diallo, Kaho Onomichi, Jiyeon Son, Zongqi Xia, Philip L. De Jager   +7 more
wiley   +1 more source

Advances in development and evaluation of bovine herpesvirus 1 vaccines

, 1996
This review deals with conventional and modern bovine herpesvirus 1 (BHV1) vaccines. Conventional vaccines are widely used to prevent clinical signs of infectious bovine rhinotracheitis.
Oirschot, J.T., van, Rijsewijk, F.A.M., Kaashoek, M.J.   +2 more
core   +2 more sources

Low Incidence of Relapses After Vaccination in Anti‐Aquaporin‐4 Antibody‐Positive NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Patients with neuromyelitis optica spectrum disorder (NMOSD) may experience increased signs and symptoms of their underlying disease when vaccinated against meningococcal disease before receiving complement component 5 inhibitor therapies. This retrospective analysis indicated an overall low relapse incidence (mean [range], 3.3% [0.7%–10.6 ...
Sean J. Pittock, Jin Nakahara, Becky Parks, Kerstin Allen, Sami Fam   +4 more
wiley   +1 more source