Results 101 to 110 of about 6,228,391 (354)

The Parkinson's progression markers initiative (PPMI) – establishing a PD biomarker cohort

Annals of Clinical and Translational Neurology, 2018
The Parkinson's Progression Markers Initiative (PPMI) is an observational, international study designed to establish biomarker‐defined cohorts and identify clinical, imaging, genetic, and biospecimen Parkinson's disease (PD) progression markers to ...
K. Marek, S. Chowdhury, A. Siderowf, Shirley Lasch, C. Coffey, C. Caspell-Garcia, T. Simuni, D. Jennings, C. Tanner, J. Trojanowski, L. Shaw, J. Seibyl, N. Schuff, A. Singleton, K. Kieburtz, A. Toga, B. Mollenhauer, D. Galasko, L. Chahine, D. Weintraub, T. Foroud, D. Tosun-Turgut, K. Poston, V. Arnedo, M. Frasier, T. Sherer, S. Bressman, M. Merchant, W. Poewe, C. Kopil, A. Naito, R. Dorsey, C. Casaceli, N. Daegele, J. Albani, L. Uribe, Eric D. Foster, J. Long, N. Seedorff, K. Crawford, Danielle Smith, P. Casalin, G. Malferrari, C. Halter, L. Heathers, D. Russell, S. Factor, P. Hogarth, A. Amara, R. Hauser, J. Jankovic, M. Stern, Shu‐Ching Hu, Gretchen Todd, R. Saunders-Pullman, I. Richard, H. Saint‐Hilaire, K. Seppi, H. Shill, Hubert H. Fernandez, C. Trenkwalder, W. Oertel, D. Berg, Kathrin Brockman, I. Wurster, L. Rosenthal, Yen F. Tai, N. Pavese, P. Barone, S. Isaacson, A. Espay, D. Rowe, M. Brandabur, J. Tetrud, G. Liang, Á. Iranzo, E. Tolosa, K. Marder, Maria de Sanchez, L. Stefanis, M. Marti, J. Martínez, J. Corvol, O. Assly, Salima Brillman, Nir Giladi, Debra Smejdir, Julia Pelaggi, F. Kausar, L. Rees, Barbara Sommerfield, Madeline Cresswell, C. Blair, Karen Williams, Grace A. Zimmerman, S. Guthrie, Ashlee Rawlins, Leigh Donharl, C. Hunter, B. Tran, A. Darin, Heli A. Venkov, Cathi A Thomas, Raymond James, B. Heim, Paul Deritis, F. Sprenger, D. Raymond, D. Willeke, Zoran Obradov, J. Mule, Nancy Monahan, K. Gauss, D. Fontaine, D. Szpak, Arita McCoy, Becky Dunlop, Laura Payne, Susan Ainscough, L. Carvajal, Rebecca Silverstein, Kristy J. Espay, Madelaine B. Rañola, E. Rezola, H. Santana, M. Stamelou, Alicia Garrido, S. Carvalho, G. Kristiansen, Krista Specketer, Anat Mirlman, M. Facheris, H. Soares, A. Mintun, J. Cedarbaum, Peggy Taylor, L. Slieker, Brian McBride, Colin Watson, Etienne Montagut, Z. Sheikh, Baris Bingol, R. Forrat, P. Sardi, T. Fischer, D Reith, J. Egebjerg, L. Larsen, N. Breysse, D. Meulien, B. Saba, V. Kiyasova, C. Min, Thomas McAvoy, R. Umek, P. Iredale, J. Edgerton, Demetrio Santi, C. Czech, F. Boess, J. Sevigny, T. Kremer, I. Grachev, K. Merchant, Andreja Avbersek, P. Muglia, Alexandra Stewart, R. Prashad, Johannes Taucher   +168 more
semanticscholar   +1 more source

Using marker-maps in marker-assisted selection

Genetical Research, 1995
SummaryA method of using information on the location of markers to improve the efficiency of markerassisted selection (MAS) in a population produced by a cross between two inbred lines is developed. The method is closer to mapping QTL than the selection index approaches to MAS described by previous authors.
J C, Whittaker, R N, Curnow, C S, Haley, R, Thompson   +3 more
openaire   +2 more sources

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

International effort toward a SSR-based linkage map for C. clementina : [P128] [PDF]

, 2008
Following the difficulties encountered for assembling a 1.2 x sequencing of the highly heterozygous sweet orange genome, the International Citrus Genomic Consortium (ICOC) decided to estab1ish the first reference sequence of a whole nuclear citrus genome
Billot, Claire, Chen, Chunxian, Costantino, Gilles, Federici, Claire T., Ferrer, R.M., Froelicher, Yann, Gmitter, Frederick G. Jr., Kacar, A.Yildiz, Lotfy, Samia, Luro, François, Morillon, Raphaël, Mu, L., Navarro, Luis, Ollitrault, Frédérique, Ollitrault, Patrick, Roose, Mikeal L., Talon, Manuel, Terol, Javier F.   +17 more
core  

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Understanding the Mysterious M2 Macrophage through Activation Markers and Effector Mechanisms

Mediators of Inflammation, 2015
The alternatively activated or M2 macrophages are immune cells with high phenotypic heterogeneity and are governing functions at the interface of immunity, tissue homeostasis, metabolism, and endocrine signaling.
Tamás Rőszer
semanticscholar   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Impact of Steroid Receptors, pS2 and Cathepsin D on the Outcome of N+ Postmenopausal Breast Cancer Patients Treated with Tamoxifen

The International Journal of Biological Markers, 1998
In spite of the complexity of the biological basis of the hormonal regulation of breast cancer, clinical studies tend to simplify the information by mainly categorizing continuous variables related to hormonal status and not considering the interactions ...
R. Dittadi, E. Biganzoli, P. Boracchi, C. Salbe, R. Mione, C. Gatti, M. Gion   +6 more
doaj   +1 more source

Wittgenstein on Knowledge (1949-1951) [PDF]

, 2003
In this paper, I want to characterize Wittgenstein"s epistemology, namely his contextualism, presented in his notes published under the title On Certainty.
Bouchard, Yves
core  

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source