Results 101 to 110 of about 1,439,039 (347)

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Life on ice, Antarctica and Mars [PDF]

The study of the origin of life and the prospects for human exploration of Mars are two themes developed in a new 57-minute film, Life on Ice, Antarctica, and Mars, produced by the InnerSpace Foundation and WHRO Television for broadcast by the Public ...
Anderson, D. T., Mckay, C. P., Sagan, C., Simmons, G. M., Squyres, S. W., Wharton, Robert A., Jr.   +5 more
core   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Discrete element method simulations of Mars Exploration Rover wheel performance

, 2015
Mars Exploration Rovers (MERs) experienced mobility problems during traverses. Three-dimensional discrete element method (DEM) simulations of MER wheel mobility tests for wheel slips of i  = 0, 0.1, 0.3, 0.5, 0.7, 0.9, and 0.99 were done to examine high ...
Jerome B. Johnson, A. Kulchitsky, P. Duvoy, K. Iagnemma, C. Senatore, R. Arvidson, J. Moore   +6 more
semanticscholar   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Subspace Method-based Blind SNR Estimation for Communication between Orbiters in Mars Exploration

ITM Web of Conferences, 2017
In Mars exploration the effective time of communication between orbiters is short, and the relative distance and gesture between them change fast. The signal to noise ratio (SNR) estimation is required in receiver to change adaptively the data rate in ...
Sun Ze-Zhou, Wang Cheng-Hua, Zhang Xiao-Fei   +2 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Site selection for manned Mars landings: A geological perspective [PDF]

Issues relating to the selection of initial landing sites for manned Mars missions are discussed from a geological viewpoint. The two prime objectives for initial manned exploration should be the youngest unambiguous lava flows (to tie down the late end ...
Spudis, Paul D.
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

AirFormer: Learning-Based Object Detection for Mars Helicopter

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
In future multiagent Mars detection schemes, the Mars helicopter can assist the scientific missions of Mars rovers by providing navigation information and scientific objects.
Yifan Qi, Xueming Xiao, Meibao Yao, Yonggang Xiong, Lei Zhang, Hutao Cui   +5 more
doaj   +1 more source