Results 131 to 140 of about 342,617 (351)

Protein connectivity in chemotaxis receptor complexes [PDF]

, 2015
The chemotaxis sensory system allows bacteria such as Escherichia coli to swim towards nutrients and away from repellents. The underlying pathway is remarkably sensitive in detecting chemical gradients over a wide range of ambient concentrations. Interactions among receptors, which are predominantly clustered at the cell poles, are crucial to this ...
arxiv   +1 more source

miRNA‐29 regulates epidermal and mesenchymal functions in skin repair

FEBS Letters, EarlyView.
miRNA‐29 inhibits cell‐to‐cell and cell‐to‐matrix adhesion by silencing mRNA targets. Adhesion is controlled by complex interactions between many types of molecules coded by mRNAs. This is crucial for keeping together the layers of the skin and for regenerating the skin after wounding.
Lalitha Thiagarajan, Rosa Sanchez‐Alvarez, Chiho Kambara, Poojitha Rajasekar, Yuluang Wang, François Halloy, Jonathan Hall, Hans‐Jürgen Stark, Iris Martin, Petra Boukamp, Svitlana Kurinna   +10 more
wiley   +1 more source

New Cardiovascular and Pulmonary Therapeutic Strategies Based on the Angiotensin-Converting Enzyme 2/Angiotensin-(1–7)/Mas Receptor Axis [PDF]

, 2012
Angiotensin (Ang)-(1–7) is now recognized as a biologically active component of the renin-angiotensin system (RAS). The discovery of the angiotensin-converting enzyme homologue ACE2 revealed important metabolic pathways involved in the Ang-(1–7 ...
Castro, Carlos Henrique, Ferreira, Anderson J., Fraga-Silva, Rodrigo A., Murça, Tatiane M., Raizada, Mohan K., Santos, Robson A. S.   +5 more
core   +3 more sources

Adhesion of membranes via receptor-ligand complexes: Domain formation, binding cooperativity, and active processes [PDF]

, 2009
Cell membranes interact via anchored receptor and ligand molecules. Central questions on cell adhesion concern the binding affinity of these membrane-anchored molecules, the mechanisms leading to the receptor-ligand domains observed during adhesion, and the role of cytoskeletal and other active processes.
arxiv   +1 more source

Spot‐14 and its paralog Spot‐14R regulate expression of metabolic and thermogenic pathway genes in murine brown and beige adipocytes

FEBS Letters, EarlyView.
Spot‐14 and Spot‐14R play distinct roles in regulating metabolism in brown and beige adipocytes. While both influence lipid and glucose pathways, Spot‐14 uniquely controls thermogenic gene expression. This dual regulation balances energy storage and heat production, highlighting potential therapeutic targets for obesity and metabolic disorders. Spot 14
Lidia Itzel Castro‐Rodríguez, Cristina Velez‐delValle, Claudia Patricia Hernández‐Mosqueira, Walid Kuri‐Harcuch   +3 more
wiley   +1 more source

An Anti-Human ICAM-1 Antibody Inhibits Rhinovirus-Induced Exacerbations of Lung Inflammation [PDF]

, 2013
Human rhinoviruses (HRV) cause the majority of common colds and acute exacerbations of asthma and chronic obstructive pulmonary disease (COPD). Effective therapies are urgently needed, but no licensed treatments or vaccines currently exist.
A Papi, A van de Stolpe, AC Palmenberg, Alan Carruthers, Alexandra Nikonova, Alison Humbles, AM Randi, Andrew J. Leishman, Andrew Pekosz, CR Uncapher, D Wat, DC Pevear, DE Staunton, DJ Jackson, DJ Jackson, DJ Jackson, FG Hayden, FG Hayden, Gary R. McLean, J Bizzintino, J Corren, J Garbino, J Las Heras, JE Gern, JE Prince, Jie Zhu, JM Greve, Katherine A. Vousden, Katie Bernard, KB Weiss, KG Nicholson, Leila Gogsadze, Matthew A. Sleeman, Michael Dymond, MS Diamond, Musa Khaitov, Nathan W. Bartlett, Nicholas Glanville, NW Bartlett, P Mallia, Q Wang, Qing Zhu, R Fleischer, Rebecca Dunmore, RF Lemanske Jr, RH Dougherty, RM Owens, Roland Kolbeck, Ross P. Walton, RR Turner, Sebastian L. Johnston, SK Lau, SL Binford, Stephanie Traub, Ted Wells, Weidong Hao, YA Bochkov   +56 more
core   +3 more sources

Mas-Related G Protein-Coupled Receptor-X2 (MRGPRX2) in Drug Hypersensitivity Reactions

Frontiers in Immunology, 2018
The human ortholog MRGPRX2 and the mice ortholog, Mrgprb2 are activated by basic secretagogues and neurokinins. A number of commonly used small-molecule drugs (e.g., neuromuscular blocking agents, fluoroquinolones, vancomycin) have been recently shown to
Grzegorz Porebski, Kamila Kwiecien, Magdalena Pawica, Mateusz Kwitniewski   +3 more
doaj   +1 more source

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

Angiotensin Converting Enzyme 2, Angiotensin-(1-7), and Receptor Mas Axis in the Kidney

International Journal of Hypertension, 2012
In the past few years the understanding of the renin-angiotensin system (RAS) has improved, helping to better define the role of this system in physiological conditions and in human diseases.
Sergio Veloso Brant Pinheiro, Ana Cristina Simões e Silva   +1 more
doaj   +1 more source

The Mas receptor mediates modulation of insulin signaling by angiotensin-(1–7)

Regulatory Peptides, 2012
Angiotensin (Ang)-(1-7) stimulates proteins belonging to the insulin signaling pathway and ameliorates the Ang II negative effects at this level. However, up to date, receptors involved and mechanisms behind these observations remain unknown. Accordingly, in the present study, we explored the in vivo effects of antagonism of the Ang-(1-7) specific Mas ...
Muñoz, Marina Cecilia, Giani, Jorge Fernando, Burghi, Valeria, Mayer, Marcos Alejandro, Carranza, Andrea del Valle, Taira, Carlos Alberto, Dominici, Fernando Pablo   +6 more
openaire   +4 more sources