pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Interation between the protooncogene mas product and the angiotensin II AT1 receptor
, 2004 1. Em vista de evidencias de que o mas proto-oncogene pode modular as respostas do receptor AT1 a angiotensina II (AngII), o objetivo deste trabalho foi avaliar, por meio de tecnicas de biologia molecular e ensaios farmacologicos, a possivel interacao ...
Santos, Edson Lucas dos [UNIFESP]
core
Envolvimento do receptor FPR2/ALX nas alterações vasculares induzidas por LPS e SEPSE [PDF]
, 2015 Tese (doutorado) - Universidade Federal de Santa catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Biotecnologia e Biociências, Florianópolis, 2015.O FPR2/ALX é um receptor acoplado à proteína G pertencente à família dos receptores de
Horewicz, Verônica Vargas
core
Alterations in gene expression in the testis of angiotensin-(1�7)-receptor Mas-deficient mice
, 2007 The Mas protooncogene encodes a G-protein coupled receptor with seven trans-membrane domains and was recently described as a receptor for angiotensin-(1 7).
Xu, P. +3 more
core +1 more source
Angiotensin(1-7) attenuates visceral adipose tissue expansion and lipogenesis by suppression of endoplasmic reticulum stress via Mas receptor. [PDF]
Nutr Metab (Lond), 2022 Ma C, Shi T, Song L, Liu J, Yuan M.
europepmc +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Novel Potential Targets for Function-Promoting Therapies: Orphan Nuclear Receptors, Anti-inflammatory Drugs, Troponin Activators, Mas Receptor Agonists, and Urolithin A. [PDF]
J Gerontol A Biol Sci Med Sci, 2023 Dioh W +8 more
europepmc +1 more source
Biophysical approaches for studying viral entry
FEBS Letters, EarlyView.Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley +1 more source
Blockade of endothelial Mas receptor restores the vasomotor response to phenylephrine in human resistance arterioles pretreated with captopril and exposed to propofol. [PDF]
BMC Anesthesiol, 2022 Schulz ME +4 more
europepmc +1 more source
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source