Results 1 to 10 of about 1,259,984 (186)

Membrane mediated mechanical stimuli produces distinct active-like states in the AT1 receptor [PDF]

Nature Communications, 2023
The Angiotensin II Type 1 (AT1) receptor is one of the most widely studied GPCRs within the context of biased signaling. While the AT1 receptor is activated by agonists such as the peptide AngII, it can also be activated by mechanical stimuli such as ...
Bharat Poudel, Rajitha Rajeshwar T, Juan M. Vanegas   +2 more
doaj   +2 more sources

Erythropoiesis and Blood Pressure Are Regulated via AT1 Receptor by Distinctive Pathways. [PDF]

PLoS ONE, 2015
The renin-angiotensin system (RAS) plays a central role in blood pressure regulation. Although clinical and experimental studies have suggested that inhibition of RAS is associated with progression of anemia, little evidence is available to support this ...
Hideki Kato, Junji Ishida, Taiji Matsusaka, Tomohiro Ishimaru, Keiji Tanimoto, Fumihiro Sugiyama, Ken-Ichi Yagami, Masaomi Nangaku, Akiyoshi Fukamizu   +8 more
doaj   +2 more sources

Sensitization of the Angiotensin II AT1 Receptor Contributes to RKIP-Induced Symptoms of Heart Failure [PDF]

Frontiers in Medicine, 2019
Inhibition of the G-protein-coupled receptor kinase 2 (GRK2) is an emerging treatment approach for heart failure. Therefore, cardio-protective mechanisms induced by GRK2 inhibition are under investigation. We compared two different GRK2 inhibitors, i.e.,
Stefan Wolf, Joshua Abd Alla, Ursula Quitterer, Ursula Quitterer   +3 more
doaj   +2 more sources

Internalization of Constitutively Active N111G Mutant of AT1 Receptor Induced by Angiotensin II–Receptor Antagonists Candesartan, Losartan, and Telmisartan: Comparison With Valsartan

Journal of Pharmacological Sciences, 2010
Based on radioligand binding and signal transduction assays in our previous study, we have determined the binding pattern and functional efficacy of the constitutively active mutant N111G of angiotensin II type 1 (AT1) receptor.
Mohiuddin Ahmed Bhuiyan, Murad Hossain, Takashi Nakamura, Masanobu Ozaki, Takafumi Nagatomo   +4 more
doaj   +2 more sources

Reassessment of the unique mode of binding between angiotensin II type 1 receptor and their blockers. [PDF]

PLoS ONE, 2013
While the molecular structures of angiotensin II (Ang II) type 1 (AT1) receptor blockers (ARBs) are very similar, they are also slightly different. Although each ARB has been shown to exhibit a unique mode of binding to AT1 receptor, different positions ...
Shin-Ichiro Miura, Naoki Nakao, Hiroyuki Hanzawa, Yoshino Matsuo, Keijiro Saku, Sadashiva S Karnik   +5 more
doaj   +1 more source

Evolutionary information helps understand distinctive features of the angiotensin II receptors AT1 and AT2 in amniota.

PLoS Computational Biology, 2022
In vertebrates, the octopeptide angiotensin II (AngII) is an important in vivo regulator of the cardiovascular system. It acts mainly through two G protein-coupled receptors, AT1 and AT2.
Rym Ben Boubaker, Asma Tiss, Daniel Henrion, Hajer Guissouma, Marie Chabbert   +4 more
doaj   +2 more sources

Effect of the renin-angiotensin system on the exacerbation of adrenal glucocorticoid steroidogenesis in diabetic mice: Role of angiotensin-II type 2 receptor

Frontiers in Endocrinology, 2022
Prior investigation shows an increase in the activity of both hypothalamus-pituitary-adrenal (HPA) axis and the renin-angiotensin system (RAS) in diabetic patients.
Amanda da Silva Chaves, Nathalia Santos Magalhães, Daniella Bianchi Reis Insuela, Patrícia Machado Rodrigues E. Silva, Marco Aurélio Martins, Vinicius Frias Carvalho, Vinicius Frias Carvalho   +6 more
doaj   +1 more source

Valsartan Attenuated Homocysteine-Induced Impaired Autophagy and ER Stress in Human Umbilical Vein Endothelial Cells

Cardiovascular Therapeutics, 2023
Hyperhomocysteinemia is a risk factor for various cardiovascular diseases. However, the mechanism underlying homocysteine- (Hcy-) induced vascular injury remains unclear.
Xinyan Wu, Ani Wang, Long Xu, Meng Li, Qingxian Zhai, Weidong Wang, Chunling Li, Lizi Jin   +7 more
doaj   +1 more source

RAGE ligands stimulate angiotensin II type I receptor (AT1) via RAGE/AT1 complex on the cell membrane

Scientific Reports, 2021
The receptor for advanced glycation end-products (RAGE) and the G protein-coupled angiotensin II (AngII) type I receptor (AT1) play a central role in cardiovascular diseases.
Serina Yokoyama, Tatsuo Kawai, Koichi Yamamoto, Huang Yibin, Hiroko Yamamoto, Akemi Kakino, Hikari Takeshita, Yoichi Nozato, Taku Fujimoto, Kazuhiro Hongyo, Toshimasa Takahashi, Futoshi Nakagami, Hiroshi Akasaka, Yoichi Takami, Yasushi Takeya, Ken Sugimoto, Tatsuya Sawamura, Hiromi Rakugi   +17 more
doaj   +1 more source

Therapeutic targets in the brain for overactive bladder: A focus on angiotensin II type 1 receptor

Journal of Pharmacological Sciences, 2023
Overactive bladder is a condition that affects both men and women, and significantly affects patients' quality of life. Anticholinergics, β3-adrenoceptor agonists, and botulinum toxin are currently being used for treatment.
Shogo Shimizu
doaj   +1 more source