Results 1 to 10 of about 20,202 (160)
Membrane mediated mechanical stimuli produces distinct active-like states in the AT1 receptor [PDF]
Nature Communications, 2023 The Angiotensin II Type 1 (AT1) receptor is one of the most widely studied GPCRs within the context of biased signaling. While the AT1 receptor is activated by agonists such as the peptide AngII, it can also be activated by mechanical stimuli such as ...
Bharat Poudel +2 more
doaj +2 more sources
Interacting molecule of AT1 receptor, ATRAP, is colocalized with AT1 receptor in the mouse renal tubules [PDF]
Kidney International, 2006 The renin-angiotensin system in the kidney plays a critical role in the regulation of renal hemodynamics and sodium handling through the activation of vascular, glomerular and tubular angiotensin II type 1 (AT1) receptor-mediated signaling. We previously cloned a molecule that specifically bound to the AT1 receptor and modulated AT1 receptor signaling ...
M Yabana, N Hirawa, Y Toya
exaly +3 more sources
The Receptor AT1 Appears to Be Important for the Maintenance of Bone Mass and AT2 Receptor Function in Periodontal Bone Loss Appears to Be Regulated by AT1 Receptor. [PDF]
Int J Mol Sci, 2021 A large number of experimental studies has demonstrated that angiotensin II (Ang II) is involved in key events of the inflammatory process. This study aimed to evaluate the role of Ang II type 1 (AT1) and Ang II type 2 (AT2) receptors on periodontitis.
Lima MLS +13 more
europepmc +4 more sources
Sensitization of the Angiotensin II AT1 Receptor Contributes to RKIP-Induced Symptoms of Heart Failure [PDF]
Frontiers in Medicine, 2019 Inhibition of the G-protein-coupled receptor kinase 2 (GRK2) is an emerging treatment approach for heart failure. Therefore, cardio-protective mechanisms induced by GRK2 inhibition are under investigation. We compared two different GRK2 inhibitors, i.e.,
Stefan Wolf +3 more
doaj +2 more sources
AT1 receptor signaling pathways in the cardiovascular system. [PDF]
Pharmacol Res, 2017 The importance of the renin angiotensin aldosterone system in cardiovascular physiology and pathophysiology has been well described whereas the detailed molecular mechanisms remain elusive. The angiotensin II type 1 receptor (AT1 receptor) is one of the key players in the renin angiotensin aldosterone system.
Kawai T +5 more
europepmc +7 more sources
Angiotensin AT1 receptor over-expression in hypercholesterolaemia
Annals of Medicine, 2000 Angiotensin II mediates most of the biological effects of the renin-angiotensin system (RAS), such as vasoconstriction and cell proliferation, via stimulation of the angiotensin II type 1 (AT1) receptor. The AT1 receptor plays a central role in the pathogenesis of atherosclerosis and hypertension.
Kerstin Strehlow, Sven Waßmann
exaly +3 more sources
The contribution of the AT1 receptor to erythropoiesis [PDF]
Biochemical Pharmacology, 2023 The renin-angiotensin system (RAS) comprises a broad set of functional peptides and receptors that play a role in cardiovascular homeostasis and contribute to cardiovascular pathologies. Angiotensin II (Ang II) is the most potent peptide hormone produced by the RAS due to its high abundance and its strong and pleiotropic impact on the cardiovascular ...
André F. Rodrigues, Michael Bader
openaire +3 more sources
Reassessment of the unique mode of binding between angiotensin II type 1 receptor and their blockers. [PDF]
PLoS ONE, 2013 While the molecular structures of angiotensin II (Ang II) type 1 (AT1) receptor blockers (ARBs) are very similar, they are also slightly different. Although each ARB has been shown to exhibit a unique mode of binding to AT1 receptor, different positions ...
Shin-Ichiro Miura +5 more
doaj +1 more source
PLoS Computational Biology, 2022 In vertebrates, the octopeptide angiotensin II (AngII) is an important in vivo regulator of the cardiovascular system. It acts mainly through two G protein-coupled receptors, AT1 and AT2.
Rym Ben Boubaker +4 more
doaj +2 more sources
Frontiers in Endocrinology, 2022 Prior investigation shows an increase in the activity of both hypothalamus-pituitary-adrenal (HPA) axis and the renin-angiotensin system (RAS) in diabetic patients.
Amanda da Silva Chaves +6 more
doaj +1 more source