Results 21 to 30 of about 1,259,984 (186)

Autoantibodies Targeting AT1 Receptor from Patients with Acute Coronary Syndrome Upregulate Proinflammatory Cytokines Expression in Endothelial Cells Involving NF-κB Pathway

Journal of Immunology Research, 2014
Our study intended to prove whether agonistic autoantibodies to angiotensin II type 1 receptor (AT1-AAs) exist in patients with coronary heart disease (CHD) and affect the human endothelial cell (HEC) by upregulating proinflammatory cytokines expression ...
Weijuan Li, Zhi Li, Yaoqi Chen, Songhai Li, Yuanyuan Lv, Wenping Zhou, Mengyang Liao, Feng Zhu, Zihua Zhou, Xiang Cheng, Qiutang Zeng, Yuhua Liao, Yumiao Wei   +12 more
doaj   +1 more source

Data on necrotic and apoptotic cell death in acute myocardial ischemia/reperfusion injury: the effects of CaMKII and angiotensin AT1 receptor inhibition

Data in Brief, 2016
Content of particular proteins indicating cellular injury due to apoptosis and necrosis has been investigated in ischemic/reperfused (IR) hearts and ischemic/reperfused hearts treated with CaMKII inhibitor and/or AT1 receptor inhibitor. This data article
Tomas Rajtik, Slavka Carnicka, Adrian Szobi, Zoltan Giricz, Jin O-Uchi, Veronika Hassova, Pavel Svec, Peter Ferdinandy, Tanya Ravingerova, Adriana Adameova   +9 more
doaj   +1 more source

Activation pathway of a G protein-coupled receptor uncovers conformational intermediates as targets for allosteric drug design

Nature Communications, 2021
G protein-coupled receptors (GPCRs) are the most common proteins targeted by approved drugs. A complete mechanistic elucidation of large-scale conformational transitions underlying the activation mechanisms of GPCRs is of critical importance for ...
Shaoyong Lu, Xinheng He, Zhao Yang, Zongtao Chai, Shuhua Zhou, Junyan Wang, Ashfaq Ur Rehman, Duan Ni, Jun Pu, Jinpeng Sun, Jian Zhang   +10 more
doaj   +1 more source

Agonist-like activity of antibodies to angiotensin II receptor subtype 1 (AT1) from rats immunized with AT1 receptor peptide

, 1999
In the present study, rats were immunized with angiotensin II receptor subtype 1 (AT1) receptor peptides for 3 months to see if the immunization produced specific anti-AT1 receptor antibodies and if continuous stimulation for 3 months affected blood ...
Schulze, W., Herlitz, H., Leung, P.S., Fu, M.L.X., Wallukat, G., Fu, H.M., Bergstroem, G.   +6 more
core   +2 more sources

Effects of a novel bradykinin B1 receptor antagonist and angiotensin II receptor blockade on experimental myocardial infarction in rats. [PDF]

PLoS ONE, 2012
The aim of the present study was to evaluate the cardiovascular effects of the novel bradykinin B1 receptor antagonist BI-113823 following myocardial infarction (MI) and to determine whether B1 receptor blockade alters the cardiovascular effects of an ...
Dongmei Wu, Xinchun Lin, Christian Bernloehr, Tobias Hildebrandt, Henri Doods   +4 more
doaj   +1 more source

Angiotensin AT1 and AT2 receptor heteromer expression in the hemilesioned rat model of Parkinson’s disease that increases with levodopa-induced dyskinesia

Journal of Neuroinflammation, 2020
Background/aims The renin-angiotensin system (RAS) is altered in Parkinson’s disease (PD), a disease due to substantia nigra neurodegeneration and whose dopamine-replacement therapy, using the precursor levodopa, leads to dyskinesias as the main side ...
Rafael Rivas-Santisteban, Ana I. Rodriguez-Perez, Ana Muñoz, Irene Reyes-Resina, José Luis Labandeira-García, Gemma Navarro, Rafael Franco   +6 more
doaj   +1 more source

Signaling of angiotensin II-induced vascular protein synthesis in conduit and resistance arteries in vivo [PDF]

, 2004
<b>Background</b> From in vitro studies, it has become clear that several signaling cascades are involved in angiotensin II-induced cellular hypertrophy.
Martens Fabrice MAC, Fabrice MAC Martens, Touyz, R.M., Daigle, Christine, Martens, Fabrice, Touyz Rhian M, Dao Huy, Christine Daigle, Huy Hao Dao, Daphné Girardot, Rhian M Touyz, Moreau Pierre, Girardot, D., Daigle, C., Dao, H., Moreau, P., Girardot, Daphné, Martens, F.M.A.C., Dao, Huy, Daigle Christine, Moreau, Pierre, Girardot Daphné, Pierre Moreau, Touyz, Rhian   +23 more
core   +2 more sources

Role of vascular smooth muscle PPARγ in regulating AT1 receptor signaling and angiotensin II-dependent hypertension. [PDF]

PLoS ONE, 2014
Peroxisome proliferator activated receptor γ (PPARγ) has been reported to play a protective role in the vasculature; however, the underlying mechanisms involved are not entirely known.
Maria Alicia Carrillo-Sepulveda, Henry L Keen, Deborah R Davis, Justin L Grobe, Curt D Sigmund   +4 more
doaj   +1 more source

Manifold active-state conformations in GPCRs: Agonist-activated constitutively active mutant AT1 receptor preferentially couples to Gq compared to the wild-type AT1 receptor [PDF]

, 2007
The angiotensin II type I (AT1) receptor mediates regulation of blood pressure and water-electrolyte balance by Ang II. Substitution of Gly for Asn111 of the AT1 receptor constitutively activates the receptor leading to Gq-coupled IP3 production ...
Chung, Hye-Shin, Bhat, Manjunatha B., Karnik, Sadashiva S., Hwang, Si Ae, Lee, ChangWoo, Jang, Sei-Heon   +5 more
core   +1 more source

Developmental changes in angiotensin II receptor subtypes and AT1 receptor mRNA in rat kidney [PDF]

, 1994
Developmental changes in angiotensin II receptor subtypes and AT1 receptor mRNA in rat kidney. The changes in angiotensin II receptor subtypes, type 1 (AT1) and type 2 (AT2) binding, and AT1 mRNA levels during development were studied in the rat kidney ...
Kapur, Shakti, Aguilera, Greti, Sunar-Akbasak, Bulbin, Bathia, Anita J., Feuillan, Penelope   +4 more
core   +1 more source