Results 11 to 20 of about 1,259,984 (186)

Engineered Mutation of Some Important Amino Acids in Angiotensin II Type 1 (AT1) Receptor Increases the Binding Affinity of AT1-Receptor Antagonists

Journal of Pharmacological Sciences, 2010
The present study was designed to examine the binding affinity and functional potency of selective angiotensin II type 1 (AT1)-receptor antagonists towards specific mutants of AT1 receptor using site-directed mutagenesis.
Mohiuddin Ahmed Bhuiyan, Murad Hossain, Masaji Ishiguro, Takashi Nakamura, Takafumi Nagatomo   +4 more
doaj   +2 more sources

AT1 expression in human urethral stricture tissue

Research and Reports in Urology, 2017
Safendra Siregar,1 Aga Parardya,1 Jupiter Sibarani,1 Tjahjodjati Romdan,1 Kuncoro Adi,1 Bethy S Hernowo,2 Anglita Yantisetiasti2 1Department of Urology, 2Department of Pathological Anatomy, Hasan Sadikin Hospital, Faculty of Medicine University of ...
Siregar S, Parardya A, Sibarani J, Romdan T, Adi K, Hernowo BS, Yantisetiasti A   +6 more
doaj   +1 more source

Angiotensin AT1–Receptor Blockers Enhance Cardiac Responses to Parasympathetic Nerve Stimulation via Presynaptic AT1 Receptors in Pithed Rats

Journal of Pharmacological Sciences, 2013
.: In the present study, we investigated the effects of angiotensin AT1–receptor blockers, KT3-671 and losartan, on the cardiac vagal neurotransmission in pithed rats.
Fumiko Yamaki, Takanori Arai, Masato Aoyama, Akane Watanabe, Yoshinobu Takata   +4 more
doaj   +2 more sources

The Receptor AT1 Appears to Be Important for the Maintenance of Bone Mass and AT2 Receptor Function in Periodontal Bone Loss Appears to Be Regulated by AT1 Receptor. [PDF]

Int J Mol Sci, 2021
A large number of experimental studies has demonstrated that angiotensin II (Ang II) is involved in key events of the inflammatory process. This study aimed to evaluate the role of Ang II type 1 (AT1) and Ang II type 2 (AT2) receptors on periodontitis ...
Lima MLS, Martins AA, Medeiros CACX, Guerra GCB, Santos R, Bader M, Pirih FQ, Araújo Júnior RF, Brito GAC, Leitão RFC, Silva RA, Barbosa SJA, Melo RCO, Araújo AA.   +13 more
europepmc   +3 more sources

Imidazole-Based AT₁ Receptor Ligands: Design, Synthesis and Pharmacological Evaluation. [PDF]

Molecules
The angiotensin II type 1 (AT1) receptor is a key component of the renin–angiotensin system (RAS) and a validated target for cardiovascular and renal disorders.
Descamps F, Rami M, Goossens JF, Melnyk P, Liberelle M, Yous S.   +5 more
europepmc   +2 more sources

AT1 receptor signaling pathways in the cardiovascular system. [PDF]

Pharmacol Res, 2017
The importance of the renin angiotensin aldosterone system in cardiovascular physiology and pathophysiology has been well described whereas the detailed molecular mechanisms remain elusive.
Kawai T, Forrester SJ, O'Brien S, Baggett A, Rizzo V, Eguchi S.   +5 more
europepmc   +2 more sources

Impaired endothelial function of the retinal vasculature in hypertensive patients [PDF]

, 2004
<p><b>Background and Purpose:</b> Arterial hypertension constitutes a central factor in the pathogenesis of stroke. We examined endothelial function of the retinal vasculature as a model of the cerebral circulation.</p> <p ...
Michelson, G., Hilgers, K.F., Oehmer, S., Harazny, J., Delles, C., Schmieder, R.E.   +5 more
core   +1 more source

Differential β-arrestin2 requirements for constitutive and agonist-induced internalization of the CB1 cannabinoid receptor [PDF]

, 2013
CB1 cannabinoid receptor (CB1R) undergoes both constitutive and agonist-induced internalization, but the underlying mechanisms of these processes and the role of beta-arrestins in the regulation of CB1R function are not completely understood.
Boros, Eszter, Hunyady, L., Gyombolai, Pál, Boros, E., Turu, G., Turu, Gábor, Gyombolai, P., Hunyady, László   +7 more
core   +1 more source

The endocytosis of oxidized LDL via the activation of the angiotensin II type 1 receptor

iScience, 2021
Summary: Arrestin-dependent activation of a G-protein-coupled receptor (GPCR) triggers endocytotic internalization of the receptor complex. We analyzed the interaction between the pattern recognition receptor (PRR) lectin-like oxidized low-density ...
Toshimasa Takahashi, Yibin Huang, Koichi Yamamoto, Go Hamano, Akemi Kakino, Fei Kang, Yuki Imaizumi, Hikari Takeshita, Yoichi Nozato, Satoko Nozato, Serina Yokoyama, Motonori Nagasawa, Tatsuo Kawai, Masao Takeda, Taku Fujimoto, Kazuhiro Hongyo, Futoshi Nakagami, Hiroshi Akasaka, Yoichi Takami, Yasushi Takeya, Ken Sugimoto, Herbert Y. Gaisano, Tatsuya Sawamura, Hiromi Rakugi   +23 more
doaj   +1 more source

Significance of Matrix Metalloproteinase-9 Inhibition by Imidapril for Prevention of Abdominal Aortic Aneurysms in Angiotensin II Type 1 Receptor–Knockout Mice

Journal of Pharmacological Sciences, 2013
To clarify the matrix metalloproteinase (MMP)-9 inhibitory effect of an angiotensin-converting enzyme (ACE) inhibitor in vivo, we evaluated the effect of an ACE inhibitor against elastase-induced abdominal aortic aneurysm (AAA) progression in mice ...
Shinji Takai, Denan Jin, Daisuke Yamamoto, Zhong-Lian Li, Yoshinori Otsuki, Mizuo Miyazaki   +5 more
doaj   +1 more source