Results 11 to 20 of about 24,420 (229)

Engineered Mutation of Some Important Amino Acids in Angiotensin II Type 1 (AT1) Receptor Increases the Binding Affinity of AT1-Receptor Antagonists

Journal of Pharmacological Sciences, 2010
The present study was designed to examine the binding affinity and functional potency of selective angiotensin II type 1 (AT1)-receptor antagonists towards specific mutants of AT1 receptor using site-directed mutagenesis.
Mohiuddin Ahmed Bhuiyan, Murad Hossain, Masaji Ishiguro, Takashi Nakamura, Takafumi Nagatomo   +4 more
doaj   +2 more sources

Erythropoiesis and Blood Pressure Are Regulated via AT1 Receptor by Distinctive Pathways. [PDF]

PLoS ONE, 2015
The renin-angiotensin system (RAS) plays a central role in blood pressure regulation. Although clinical and experimental studies have suggested that inhibition of RAS is associated with progression of anemia, little evidence is available to support this ...
Hideki Kato, Junji Ishida, Taiji Matsusaka, Tomohiro Ishimaru, Keiji Tanimoto, Fumihiro Sugiyama, Ken-Ichi Yagami, Masaomi Nangaku, Akiyoshi Fukamizu   +8 more
doaj   +2 more sources

Internalization of Constitutively Active N111G Mutant of AT1 Receptor Induced by Angiotensin II–Receptor Antagonists Candesartan, Losartan, and Telmisartan: Comparison With Valsartan

Journal of Pharmacological Sciences, 2010
Based on radioligand binding and signal transduction assays in our previous study, we have determined the binding pattern and functional efficacy of the constitutively active mutant N111G of angiotensin II type 1 (AT1) receptor.
Mohiuddin Ahmed Bhuiyan, Murad Hossain, Takashi Nakamura, Masanobu Ozaki, Takafumi Nagatomo   +4 more
doaj   +2 more sources

AT1 expression in human urethral stricture tissue

Research and Reports in Urology, 2017
Safendra Siregar,1 Aga Parardya,1 Jupiter Sibarani,1 Tjahjodjati Romdan,1 Kuncoro Adi,1 Bethy S Hernowo,2 Anglita Yantisetiasti2 1Department of Urology, 2Department of Pathological Anatomy, Hasan Sadikin Hospital, Faculty of Medicine University of ...
Siregar S, Parardya A, Sibarani J, Romdan T, Adi K, Hernowo BS, Yantisetiasti A   +6 more
doaj   +1 more source

Angiotensin AT1–Receptor Blockers Enhance Cardiac Responses to Parasympathetic Nerve Stimulation via Presynaptic AT1 Receptors in Pithed Rats

Journal of Pharmacological Sciences, 2013
.: In the present study, we investigated the effects of angiotensin AT1–receptor blockers, KT3-671 and losartan, on the cardiac vagal neurotransmission in pithed rats.
Fumiko Yamaki, Takanori Arai, Masato Aoyama, Akane Watanabe, Yoshinobu Takata   +4 more
doaj   +2 more sources

Vasopressor meets vasodepressor: The AT1–B2 receptor heterodimer [PDF]

Biochemical Pharmacology, 2014
The AT1 receptor for the vasopressor angiotensin II is one of the most important drug targets for the treatment of cardiovascular diseases. Sensitization of the AT1 receptor system is a common feature contributing to the pathogenesis of many cardiovascular disorders but underlying mechanisms are not fully understood.
Quitterer Ursula, AbdAlla Said
openaire   +6 more sources

Oxidized low-density lipoprotein potentiates angiotensin II-induced Gq activation through the AT1-LOX1 receptor complex [PDF]

eLife
Chronic kidney disease (CKD) and atherosclerotic heart disease, frequently associated with dyslipidemia and hypertension, represent significant health concerns.
Jittoku Ihara, Yibin Huang, Yoichi Takami, Yoichi Nozato, Toshimasa Takahashi, Akemi Kakino, Cheng Wang, Ziwei Wang, Yu Guo, Weidong Liu, Nanxiang Yin, Ryoichi Ohara, Taku Fujimoto, Shino Yoshida, Kazuhiro Hongyo, Hiroshi Koriyama, Hiroshi Akasaka, Hikari Takeshita, Shinsuke Sakai, Kazunori Inoue, Yoshitaka Isaka, Hiromi Rakugi, Tatsuya Sawamura, Koichi Yamamoto   +23 more
doaj   +3 more sources

Renal responses to AT1 receptor blockade [PDF]

American Journal of Hypertension, 2000
Because of the importance of the renin-angiotensin system in the pathophysiology of hypertension and in mediating associated alterations in renal function, angiotensin II (Ang II) AT1 receptor blockers provide a direct means of protecting against influences of excessive Ang II levels.
L G, Navar, L M, Harrison-Bernard, J D, Imig, L, Cervenka, K D, Mitchell   +4 more
openaire   +2 more sources

Valsartan Attenuated Homocysteine-Induced Impaired Autophagy and ER Stress in Human Umbilical Vein Endothelial Cells

Cardiovascular Therapeutics, 2023
Hyperhomocysteinemia is a risk factor for various cardiovascular diseases. However, the mechanism underlying homocysteine- (Hcy-) induced vascular injury remains unclear.
Xinyan Wu, Ani Wang, Long Xu, Meng Li, Qingxian Zhai, Weidong Wang, Chunling Li, Lizi Jin   +7 more
doaj   +1 more source

RAGE ligands stimulate angiotensin II type I receptor (AT1) via RAGE/AT1 complex on the cell membrane

Scientific Reports, 2021
The receptor for advanced glycation end-products (RAGE) and the G protein-coupled angiotensin II (AngII) type I receptor (AT1) play a central role in cardiovascular diseases.
Serina Yokoyama, Tatsuo Kawai, Koichi Yamamoto, Huang Yibin, Hiroko Yamamoto, Akemi Kakino, Hikari Takeshita, Yoichi Nozato, Taku Fujimoto, Kazuhiro Hongyo, Toshimasa Takahashi, Futoshi Nakagami, Hiroshi Akasaka, Yoichi Takami, Yasushi Takeya, Ken Sugimoto, Tatsuya Sawamura, Hiromi Rakugi   +17 more
doaj   +1 more source