Results 41 to 50 of about 24,420 (229)

Constitutively Active Mutant N111G of Angiotensin II Type 1 (AT1) Receptor Induces Homologous Internalization Through Mediation of AT1-Receptor Antagonist

Journal of Pharmacological Sciences, 2009
The present study investigated the internalization behavior of the constitutively active mutant (CAM) N111G of angiotensin II type 1 (AT1) receptor and correlated the result with the mechanism of the constitutive activity of the mutant.
Mohiuddin Ahmed Bhuiyan, Murad Hossain, Shin-ichiro Miura, Takashi Nakamura, Masanobu Ozaki, Takafumi Nagatomo   +5 more
doaj   +1 more source

Preparation and Biological Activity of the Monoclonal Antibody against the Second Extracellular Loop of the Angiotensin II Type 1 Receptor

Journal of Immunology Research, 2016
The current study was to prepare a mouse-derived antibody against the angiotensin II type 1 receptor (AT1-mAb) based on monoclonal antibody technology, to provide a foundation for research on AT1-AA-positive diseases.
Mingming Wei, Chengrui Zhao, Suli Zhang, Li Wang, Huirong Liu, Xinliang Ma   +5 more
doaj   +1 more source

Histone Modification Complex JMJ704‐HDA709 Negatively Regulates Salinity Tolerance in Rice

Advanced Science, EarlyView.
This study reveals that the rice histone demethylase JMJ704 interacts with HDA709―a H3K9ac deacetylase characterized herein―to form a chromatin‐modifying complex. Under salt stress, OsWRKY72 recruits this complex through interaction with JMJ704 to target loci, repressing the expression of oxidative stress and salt‐responsive genes via removal of ...
Jing Wang, Zhengting Chen, Pengxiang Bai, Biao Liu, Lingling Meng, Jian Zhang, Xu Li, Dao‐Xiu Zhou, Xuan Ma, Yu Zhao   +9 more
wiley   +1 more source

SDPR–STK38 axis controls the proliferation–differentiation balance in alveolar type II cells

Animal Models and Experimental Medicine, EarlyView.
The present study identifies SDPR as a pivotal regulator orchestrating the balance between proliferation and differentiation in alveolar type II (AT2) cells. In SDPR+/+ cells, SDPR binds to and inhibits STK38 activity, thereby sustaining GSK‐3β signaling functionality to promote cyclin D1 degradation and maintain cell cycle homeostasis.
Jie Wang, Xuepei Lei, Yiying Huang, Jiaming Tang, Guiying Shi, Hang Li, Lin Bai   +6 more
wiley   +1 more source

Influence of AT1 Receptor Activity on AT1 and AT2 Receptor Expression During Fetal Life. † 284 [PDF]

Pediatric Research, 1997
The present study was designed to test the hypothesis that an increase in AT1 receptor activity participates in the decline in AT2 mRNA expression associated with fetal maturation (Pediatr Res 38:896904, 1995). To test this hypothesis, we studied eleven pairs of chronically instrumented twin fetal sheep at 95d gestation and seven pairs at 110d ...
Jean A. Petershack, Margaret E. Samyn, Jeffrey L. Segar, Jean E. Robillard   +3 more
openaire   +1 more source

Faith, Sustainability and Consumer Trust in Halal–Green Cosmetics: A Dual‐Trust Model Among Muslim Women

Business Strategy and the Environment, EarlyView.
ABSTRACT This study examines how firms secure legitimacy in markets where faith‐based expectations and environmental responsibility intersect, focusing on halal–green cosmetics among Muslim women. It conceptualises halal trust and green trust as parallel legitimacy pathways reflecting faith‐based legitimacy and environmental credibility, respectively ...
Dwi Suhartanto, Ani Kartikasari, Gundur Leo, Sitti Nur Azmi Fadhlurrahmah, Adelia Athifah Ambartola   +4 more
wiley   +1 more source

Angiotensin type-1 receptor autoantibodies promote alpha-synuclein aggregation in dopaminergic neurons

Frontiers in Immunology
Angiotensin, through its type-1 receptor (AT1), is a major inducer of inflammation and oxidative stress, contributing to several diseases. Autoimmune processes have been involved in neurodegeneration, including Parkinson’s disease (PD).
Lucia Lage, Ana I. Rodríguez-Perez, Ana I. Rodríguez-Perez, Jose L. Labandeira-Garcia, Jose L. Labandeira-Garcia, Antonio Dominguez-Meijide, Antonio Dominguez-Meijide   +6 more
doaj   +1 more source

ESG Ratings and Firms' Engagement in Global Innovation Ecosystems: Implications for Green Innovation Capacity

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT The increasing salience of climate change has intensified attention to the roe of ESG ratings in shaping firms' green innovation. We examine the link between ESG performance and green innovation, highlighting the role of participation in global innovation networks.
Miaomiao Tao, David Roubaud, Mingzhi Zhang, Qianli Ma   +3 more
wiley   +1 more source

Preparation, Radiolabeling with ⁶⁸Ga/¹⁷⁷Lu and Preclinical Evaluation of Novel Angiotensin Peptide Analog: A New Class of Peptides for Breast Cancer Targeting

Pharmaceuticals, 2023
Aim: Angiotensin II (AngII) is known to play a significant part in the development of breast cancer by triggering cell propagation of breast cancer, tumor angiogenesis, and regulating tumor invasion and cell migration. AngII arbitrates its action via two
Subhani M. Okarvi
doaj   +1 more source

Cancer, inflammation and the AT1 and AT2 receptors.

Journal of inflammation (London, England), 2004
The critical role of inappropriate inflammation is becoming accepted in many diseases that affect man, including cardiovascular diseases, inflammatory and autoimmune disorders, neurodegenerative conditions, infection and cancer.This review proposes that cancer up-regulates the angiotensin II type 1 (AT1) receptor through systemic oxidative stress and ...
Smith Gary, Missailidis Sotiris
openaire   +4 more sources