Results 61 to 70 of about 1,259,984 (186)

The Physician Global Assessment as a Proxy for Photoaging: Validation in an Observational Real‐World Cohort Using SCINEXA as the Reference Standard

JEADV Clinical Practice, EarlyView.
ABSTRACT Background Photoaging is a chronic skin condition caused by cumulative ultraviolet exposure superimposed on intrinsic aging. Although the SCore of INtrinsic and EXtrinsic skin Aging (SCINEXA) is a validated multidimensional instrument for assessing photoaging, the Physician Global Assessment (PGA) is a simpler clinician‐reported measure whose ...
Ewout Baerveldt, Eric van Sprang, Henk‐Jan Ramaker, Robert T. Aeneae Venema, Thomas Rustemeyer, Jorrit Terra, Perry J. J. van Genderen   +6 more
wiley   +1 more source

Decreased angiotensin receptor 1 expression in ± AT1 Knockout mice testis results in male infertility and GnRH reduction

Reproductive Biology and Endocrinology, 2021
Background This study aimed to detect the effect of angiotensin receptor 1 (AT1) knock out (KO) on spermatogenesis and hypothalamic-pituitary–gonadal (HPG) axis hormone expression.
Fangfang Zhao, Yun Zou, Hui Li, Yaheng Zhang, Xuele Liu, Xuehao Zhao, Xinyi Wu, Wenyi Fei, Ziling Xu, Xuejun Yang   +9 more
doaj   +1 more source

Multitarget Regulatory Mechanisms and Research Advances of Plant‐Derived Bioactive Ingredients in Hypertension Prevention and Management

Phytotherapy Research, EarlyView.
Schematic overview of the multi‐target and multi‐pathway mechanisms of PDBI in the prevention and management of hypertension. ABSTRACT Hypertension remains a major global risk factor for cardiovascular diseases, yet current treatments face challenges such as suboptimal blood pressure control and inadequate organ protection.
Qiqi Deng, Yonglin Zhang, Jing Pan, Jing Luo, Hualin Sun, Chaonian Li, Li Li   +6 more
wiley   +1 more source

Angiotensin AT1 Receptor Blockade Protects the Brain from Ischemic Damage [PDF]

, 2007
Angiotensin (Ang) AT1 receptors are considered to play an important role in ischemic stroke via degenerative processes leading to cell death. Recent clinical and basic studies show that systemic blockade of Ang AT1 receptors reduces brain lesion in ...
Penchikala, Madhuri
core   +2 more sources

The Angiotensin II Type 1 Receptor Antagonist Losartan Affects NHE1-Dependent Melanoma Cell Behavior

Cellular Physiology and Biochemistry, 2018
Background/Aims: The peptide hormone angiotensin II (ATII) plays a prominent role in regulating vasoconstriction and blood pressure. Its primary target is the angiotensin II receptor type 1 (AT1), the stimulation of which induces an increase in cytosolic
Daniel Navin Olschewski, Verena Hofschröer, Nikolaj Nielsen, Daniela G. Seidler, Albrecht Schwab, Christian Stock   +5 more
doaj   +1 more source

Oxadiazolone-Triazole Derivatives as a New Scaffold for Modulation of Angiotensin II-Induced Vascular Contraction. [PDF]

ChemMedChem
A novel series of candidate AT1 receptor antagonists based on oxadiazolone‐triazole scaffolds was designed and synthesized. Most compounds reduced angiotensin II‐induced vascular contraction in an initial biological screening, with compound 7f emerging as the most active derivative.
Ferreira LFL, Vasconcelos DGA, Santos RCA, Ferreira JG, Araújo AV, Anjos JVD.   +5 more
europepmc   +2 more sources

Integrative Approaches in Cardiovascular Disease: The Role of Nutraceuticals in Heart Failure, Atrial Fibrillation, and Related Conditions

Phytotherapy Research, EarlyView.
Schematic representation of the shared pathophysiological mechanisms underlying heart failure (HF) and atrial fibrillation (AF), including inflammation, oxidative stress, endothelial dysfunction, and fibrosis. The figure highlights the clinical and mechanistic convergence of conventional pharmacological therapies and selected nutraceuticals in ...
Laura Beatrice Mattioli, Ivan Corazza, Roberta Budriesi, Luca Camarda, Maria Carelli, Alberto Spadotto, Igor Diemberger   +6 more
wiley   +1 more source

Coexpression of AT1 and AT2 receptors by human fibroblasts is associated with resistance to angiotensin II

, 2005
Angiotensin II (AngII) is considered as a cytokine-like factor displaying a variety of proinflammatory and profibrotic cellular effects. Most of these effects seem mediated by AT1 signaling, whereas AT2 expression and function in adult human cells remain
Santiago, Begoña, Galindo Izquierdo, María, Pablos Álvarez, José Luis, Ramírez Fernández, Juan Carlos, Palao, Guillermo, Gutiérrez Cañas, Irene   +5 more
core   +1 more source

Fitting in and feeling good: Reciprocal associations between peer acceptance and emotions in the classroom

British Journal of Educational Psychology, EarlyView.
Abstract Background According to the control‐value theory of achievement emotions, the classroom social environment is an important antecedent of children's emotions, with emotions, in turn, influencing this environment. We focus on a in CVT largely neglected but important aspect of CVT that has been largely neglected: peer relationships.
Tim Mainhard, Elisabeth Graf, Minke A. Krijnen, Lian Van Vemde, Bjorn G. J. Wansink, Thomas Goetz   +5 more
wiley   +1 more source

Effect of ang II AT1 receptor antagonists, on periodontal disease induced by injections of lipopolysaccharide in rats.

, 2013
La Enfermedad Periodontal (EP) es una condición inflamatoria progresiva que afecta los tejidos que soportan y rodean a los dientes. Las endotoxinas bacterianas como los lipopolisacáridos (LPS), inducen una cascada inflamatoria causando resorción ósea ...
Matos Uzcategui, Maria Gabriela
core   +1 more source