Results 61 to 70 of about 24,420 (229)

Developmental changes in angiotensin II receptor subtypes and AT1 receptor mRNA in rat kidney

, 1994
Developmental changes in angiotensin II receptor subtypes and AT1 receptor mRNA in rat kidney. The changes in angiotensin II receptor subtypes, type 1 (AT1) and type 2 (AT2) binding, and AT1 mRNA levels during development were studied in the rat kidney ...
Kapur, Shakti, Aguilera, Greti, Sunar-Akbasak, Bulbin, Bathia, Anita J., Feuillan, Penelope   +4 more
core   +1 more source

Renal‐vascular axis: unmasking its role in vascular endothelial growth factor‐inhibitor vascular toxicity in cancer patients

British Journal of Pharmacology, EarlyView.
Abstract Vascular toxicity is a growing concern in cancer patients receiving vascular endothelial growth factor inhibitor (VEGFi) therapy, posing a significant threat to patient prognosis. While the primary mechanism of VEGFi‐induced vascular toxicity is linked to redox‐sensitive reactions that disrupt vascular tone, leading to hypertension and ...
Grace Whelan, Karla B. Neves
wiley   +1 more source

Exercício de força ativa a via AKT/mTor pelo receptor de angiotensina II tipo I no músculo cardíaco de ratos Activation of AKT-mTor signaling pathways by angiotensin II receptor type 1 after a session of strength exercise in cardiac muscle of rats

Revista Brasileira de Educação Física e Esporte : RBEFE, 2011
O receptor de angiotensina II tipo I (AT1) tem uma importante participação no desenvolvimento da hipertrofia cardíaca. Em um trabalho publicado anteriormente, por nosso grupo, demonstramos que o bloqueio do receptor AT1 durante o treinamento de força ...
Stéphano Freitas Soares Melo, Marco Aurélio Amadeu, Flávio de Castro Magalhães, Tiago Fernandes, Everton Crivoi do Carmo, Diego Lopes Mendes Barretti, Patrícia Chakur Brum, Edilamar Menezes de Oliveira   +7 more
doaj   +1 more source

miR-339-3p promotes AT1-AA-induced vascular inflammation by upregulating NFATc3 protein expression in vascular smooth muscle cells

Acta Biochimica et Biophysica Sinica, 2023
Vascular inflammation induced by angiotensin II-1 receptor autoantibody (AT1-AA) is involved in the occurrence and development of various cardiovascular diseases.
Li Yang, Long Yaolin, Zhi Xiaoyan, Hao Haihu, Wang Xiaohui, Liu Huirong, Wang Li   +6 more
doaj   +1 more source

A comprehensive review of cancer‐induced cardiac wasting

British Journal of Pharmacology, EarlyView.
Cancer is frequently accompanied by cachexia, a systemic syndrome characterized by progressive loss of skeletal muscle mass, with or without loss of fat mass. Increasing evidence indicates that cancer can also induce cardiac muscle wasting, which is associated with structural cardiac remodelling, impaired contractile function and the development of ...
Alessia Lena, Muhammad Shahzeb Khan, Ulrich Keller, Lars Bullinger, Dominik P. Modest, Markus S. Anker   +5 more
wiley   +1 more source

Atrial natriuretic peptide counteracts aldosterone secretion by preventing acute angiotensin II‐induced cAMP signalling

British Journal of Pharmacology, EarlyView.
Background and Purpose Aldosterone plays a key role in blood pressure and volume regulation. Enhanced aldosterone secretion contributes to cardiovascular and renal diseases. Therefore, inhibitors of aldosterone receptors and synthase are essential drugs for the treatment of hypertension and heart failure.
Sanika Mohagaonkar, Egor B. Skryabin, Bettina M. Buchholz, Michaela Kuhn, Celso E. Gomez‐Sanchez, Stepan Gambaryan, Viacheslav O. Nikolaev   +6 more
wiley   +1 more source

Decreased angiotensin receptor 1 expression in ± AT1 Knockout mice testis results in male infertility and GnRH reduction

Reproductive Biology and Endocrinology, 2021
Background This study aimed to detect the effect of angiotensin receptor 1 (AT1) knock out (KO) on spermatogenesis and hypothalamic-pituitary–gonadal (HPG) axis hormone expression.
Fangfang Zhao, Yun Zou, Hui Li, Yaheng Zhang, Xuele Liu, Xuehao Zhao, Xinyi Wu, Wenyi Fei, Ziling Xu, Xuejun Yang   +9 more
doaj   +1 more source

Comparative evaluation of biased agonists Sarcosine1, d‐Alanine8‐Angiotensin (Ang) II (SD Ang II) and Sarcosine1, Isoleucine8‐Ang II (SI Ang II) and their radioiodinated congeners binding to rat liver membrane AT1 receptors

Pharmacology Research & Perspectives, 2023
Angiotensin II analogue and β‐arrestin biased agonist TRV027 (Sarcosine1, d‐Alanine8‐Angiotensin (Ang) II; SD Ang II), developed by Trevena, Inc. in the early 2010s, brought hopes of a novel treatment for cardiovascular diseases, due to its ability to ...
Natalia M. Noto, Yazmin M. Restrepo, Hong W. Pang, Filipe Stoyell‐Conti, Crystal A. West, Robert C. Speth   +5 more
doaj   +1 more source

Angiotensin II Receptor Subtypes AT1 and AT2 Are Down-Regulated by Angiotensin II through AT1 Receptor by Different Mechanisms* [PDF]

Endocrinology, 1997
The regulatory effects of angiotensin II (AngII) on its receptor subtypes, AT1 and AT2, were studied using cultured bovine adrenal cells (BAC), which express both receptor subtypes, and PC12W and R3T3 cells, which express only AT2 receptors. In BAC, AngII caused a decrease in AT1- and AT2-binding sites and their corresponding messenger RNAs (mRNAs ...
Ouali, Radouane, Berthelon, M.C., Bégeot, Martine, Saez, J.M.   +3 more
openaire   +3 more sources

Hypercholesterolemia is associated with enhanced angiotensin AT1-receptor expression

, 1997
Low-density lipoprotein increases the AT1-receptor gene expression in vascular smooth muscle cells. To elucidate whether elevated cholesterol serum levels upregulate the AT1 receptor and its functional response to angiotensin II in vivo, we compared 1 ...
K. Strehlow, M. Bohm, O. Jung, W. Linz, G. Nickenig, O. Zolk, B. A. Scholkens   +6 more
core   +1 more source